Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Kurt Eger"'
Publikováno v:
Apoptosis. 12:235-246
Trans-beta-nitrostyrene (TBNS) has been reported to be a potent inhibitor of protein phosphatases PTB1 and PP2A and to display a pro-apoptotic effect even in multidrug resistant tumour cells. Here we compared the anti-tumour potential of TBNS with 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa42dd42ede6f8f1ced2cf58a2e30a38
https://doi.org/10.1007/s10495-006-0530-x
https://doi.org/10.1007/s10495-006-0530-x
Publikováno v:
Biochemical Pharmacology. 67:919-926
6- O -Palmitoyl ascorbic acid (PAA) has recently been used as a substitute for ascorbic acid because of its greater potency as an antioxidant. In detailed concentration response studies distinct cytotoxic effects of PAA at concentrations exceeding 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f1908087fc1c1be775c1d7d47f87d7
https://doi.org/10.1016/j.bcp.2003.10.001
https://doi.org/10.1016/j.bcp.2003.10.001
Publikováno v:
European Journal of Organic Chemistry. 2004:894-898
Hypervalent iodine oxidation of emodin (1) with various (diacetoxyiodo)arenes 2a−f in potassium hydroxide/methanol leading to 3-aryloxy-1,8-dihydroxy-2-iodo-anthraquinones 4a−f is reported. Mechanistic studies showed reaction via iodonium ylides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa3ef8078fc9830a55d02fb5d06efc8
https://doi.org/10.1002/ejoc.200300317
https://doi.org/10.1002/ejoc.200300317
Autor:
Hans Jürgen Steinfelder, Iris Quentin, Mohammed Shaheen, Sylvia Kaap, Dereje Tamiru, Kurt Eger
Publikováno v:
Biochemical Pharmacology. 65:603-610
In the present study, we outlined the part of the molecule mediating the prominent pro-apoptotic effect of the Michael adduct of ascorbic acid with p-chloro-nitrostyrene, a new synthetic phosphatase inhibitor. The nitrostyrene (NS) moiety was identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a029f74eac2edc1c0ffe12253a913e
https://doi.org/10.1016/s0006-2952(02)01618-0
https://doi.org/10.1016/s0006-2952(02)01618-0
Autor:
Stefan Benard, Michael Gütschow, Sunna Hauschildt, Kurt Eger, Jürgen Arnhold, Sabine Reichl, Uta Witt
Publikováno v:
Pharmacology. 66:162-168
The effects of Michael adducts of 6-O-palmitoyl-L-ascorbic acid (compounds 1–4) on the phosphorylation-dependent response of stimulated monocytes and neutrophils was investigated. The pyranosyl derivative 3 increased the production of tumor necrosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9689129f426d199fbd3ac9567d106264
https://doi.org/10.1159/000063799
https://doi.org/10.1159/000063799
Publikováno v:
European Journal of Pharmaceutical Sciences. 14:301-311
The anti-inflammatory drug indomethacin was investigated regarding new related impurities. Therefore, related substances 2-9 were prepared by independent synthesis and physicochemically characterized. To determine indomethacin and its related substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7d0653f148d0c38f88277121cc96b5
https://doi.org/10.1016/s0928-0987(01)00198-1
https://doi.org/10.1016/s0928-0987(01)00198-1
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 25:531-538
Trimethoprim is a chemotherapeutic often used in combination with sulfonamides. Herein, we report on the development and validation of a new HPLC assay of trimethoprim. The test allows the identification of new impurities that have not been detectabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9042a6803c9de452d880a8dc34c248
https://doi.org/10.1016/s0731-7085(00)00595-1
https://doi.org/10.1016/s0731-7085(00)00595-1
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1279-1291
A series of new water-soluble thalidomide prodrugs was prepared. All compounds were derivatized on the nitrogen of the glutarimide ring. Esters of natural amino acids and succinic acid derivatives have been introduced by reaction with the hydroxymeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f3431b75fde6c6ca01dd5ea201dea2
https://doi.org/10.1016/s0968-0896(00)00342-4
https://doi.org/10.1016/s0968-0896(00)00342-4
Publikováno v:
Journal of Heterocyclic Chemistry. 37:1187-1191
Reaction of 6-chloropyrimidines with diethyl [(2-aminoethoxy)methyl]phosphonate allows for a ready access to acyclic nucleoside phosphonates. A series of 5-substituted pyrimidines bearing a phosphonate side chain at position 6 were synthesized and te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b575b8f68a77edd2447ea2ae3a3aafa6
https://doi.org/10.1002/jhet.5570370527
https://doi.org/10.1002/jhet.5570370527
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:807-813
By investigating the stereospecific Michael reaction of derivatives of ascorbic acid with acrolein we obtained a novel class of protein Ser/Thr phosphatase inhibitors. The inhibitory effect of the Michael adducts was examined using the canonical prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1487eb6680747ab0354400b4007ebb3f
https://doi.org/10.1016/s0968-0896(00)00013-4
https://doi.org/10.1016/s0968-0896(00)00013-4