Výsledky vyhledávání - "Kurt E. Amrein"

Akademický článek

THP-1 macrophages and SGBS adipocytes - a new human in vitro model system of inflamed adipose tissue

Autor: Michaela eKeuper, Anna eDzyakanchuk, Kurt E Amrein, Martin eWabitsch, Pamela eFischer-Posovszky

Publikováno v: Frontiers in Endocrinology, Vol 2 (2011)

Obesity is associated with an accumulation of macrophages in adipose tissue. This inflammation of adipose tissue is a key event in the pathogenesis of several obesity-related disorders, particularly insulin resistance.Here, we summarized existing mod

Externí odkaz: https://doaj.org/article/4691f88a36fa4a928263f40f7a505e02

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Stimulation of Phosphorylation of Tyr394 by Hydrogen Peroxide Reactivates Biologically Inactive, Non-membrane-bound Forms of Lck

Autor: James S. Hardwick, Lara K. Yurchak, Kathryn Pierno, Bartholomew M. Sefton, Kurt E. Amrein

Publikováno v: Journal of Biological Chemistry. 271:12549-12554

Lck, a lymphocyte-specific tyrosine protein kinase, is bound to cellular membranes as the result of myristoylation and palmitoylation of its amino terminus. Its activity is inhibited by phosphorylation of tyrosine 394. The Tyr-505 --> Phe mutant of L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d190b0b021118c05577de5d8c584ddd
https://doi.org/10.1074/jbc.271.21.12549

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Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts

Autor: Kurt E. Amrein, Bartholomew M. Sefton

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 85(12)

p56lck, a cellular tyrosine protein kinase (EC 2.7.1.112) of the src family, is expressed in essentially all T cells and in some B cells. Expression in nonlymphoid cells is observed only rarely. We have found that mutation of a carboxyl-terminal phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0ea63fd6d4fd5c36e2063892fbdadc
https://pubmed.ncbi.nlm.nih.gov/3380789

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The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

Autor: Kurt E. Amrein, John K. Rose, Bartholomew M. Sefton, David F. Stern, Andrey S. Shaw, Craig Hammond

Publikováno v: Cell. 59(4)

The CD4 lymphocyte surface glycoprotein and the lck tyrosine protein kinase p56lck are found as a complex in T lymphocytes. We have defined the domains in both proteins that are responsible for this interaction by coexpressing hybrid and deleted form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd2869363d124e6a132faf48384eb37
https://pubmed.ncbi.nlm.nih.gov/2582490

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