Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Kurt A, Zimmerman"'
Autor:
Kyle P. Jansson, Jordan Kuluva, Shiqin Zhang, Taylor Swanson, Yan Zhang, Kurt A. Zimmerman, Timothy A. Fields, Darren P. Wallace, Peter S. Rowe, Jason R. Stubbs
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Osteopontin (OPN) is a multi‐functional glycoprotein that coordinates the innate immune response, prevents nanocrystal formation in renal tubule fluid, and is a biomarker for kidney injury. OPN expression is markedly increased in cystic ep
Externí odkaz:
https://doaj.org/article/15be34ec754f420ba0668b95d8c7b8af
Autor:
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114253- (2024)
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profile
Externí odkaz:
https://doaj.org/article/c26ba69a6afe47bdbc7deb8408bb9ad1
Autor:
Emily K. Kleczko, Dustin T. Nguyen, Kenneth H. Marsh, Colin D. Bauer, Amy S. Li, Marie-Louise T. Monaghan, Michael D. Berger, Seth B. Furgeson, Berenice Y. Gitomer, Michel B. Chonchol, Eric T. Clambey, Kurt A. Zimmerman, Raphael A. Nemenoff, Katharina Hopp
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Innate and adaptive immune cells modulate the severity of autosomal dominant polycystic kidney disease (ADPKD), a common kidney disease with inadequate treatment options. ADPKD has parallels with cancer, in which immune checkpoint inhibitors have bee
Externí odkaz:
https://doaj.org/article/db0e24d1120a4e91b18a5137cdd01738
Autor:
Alex Yashchenko, Sarah J. Bland, Cheng J. Song, Ummey Khalecha Bintha Ahmed, Rachel Sharp, Isabella G. Darby, Audrey M. Cordova, Morgan E. Smith, Jeremie M. Lever, Zhang Li, Ernald J. Aloria, Shuja Khan, Bibi Maryam, Shanrun Liu, Michael R. Crowley, Kenneth L. Jones, Lauren A. Zenewicz, James F. George, Michal Mrug, David K. Crossman, Katharina Hopp, Stavros Stavrakis, Mary B. Humphrey, Florent Ginhoux, Kurt A. Zimmerman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Kidney macrophages are comprised of both monocyte-derived and tissue resident populations; however, the heterogeneity of kidney macrophages and factors that regulate their heterogeneity are poorly understood. Herein, we performed single cell RNA sequ
Externí odkaz:
https://doaj.org/article/33bd5d09e8bc4889bac131cdfd30c35a
Autor:
Zhang Li, Kurt A. Zimmerman, Sreelakshmi Cherakara, Phillip H. Chumley, James F. Collawn, Jun Wang, Courtney J. Haycraft, Cheng J. Song, Teresa Chacana, Reagan S. Andersen, Mandy J. Croyle, Ernald J. Aloria, Raksha P. Hombal, Isis N. Thomas, Hanan Chweih, Kristin L. Simanyi, James F. George, John M. Parant, Michal Mrug, Bradley K. Yoder
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 1 (2023)
Externí odkaz:
https://doaj.org/article/d33111929bb3477fae3f2ddadac69a61
Autor:
Yukitaka Kani, Thomas E. Cecere, Kevin Lahmers, Tanya LeRoith, Kurt L. Zimmerman, Scott Isom, Fang‐Chi Hsu, Waldemar Debinksi, John L. Robertson, John H. Rossmeisl
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 33, Iss 3, Pp 1384-1391 (2019)
Abstract Background Stereotactic brain biopsy (SBB) is a technique that allows for definitive diagnosis of brain lesions. Little information is available regarding the diagnostic utility of SBB in dogs with intracranial diseases. Objective To investi
Externí odkaz:
https://doaj.org/article/350248c1c27d4d93b080583b071623f1
Publikováno v:
Veterinary Clinical Pathology. 52:38-43
A 9-year-old female spayed Boston Terrier presented for diagnostic investigation of lethargy, poor appetite, weight loss, and a marked leukocytosis. Significant muscle wasting and a palpable abdominal mass were present on physical examination. Abdomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60682a862043983e1f65066246bde221
https://doi.org/10.1111/vcp.13143
https://doi.org/10.1111/vcp.13143
Autor:
Cheng J. Song, Zhang Li, Ummey Khalecha Bintha Ahmed, Sarah J. Bland, Alex Yashchenko, Shanrun Liu, Ernald J. Aloria, Jeremie M. Lever, Nancy M. Gonzalez, Marisa A. Bickel, Cory B. Giles, Constantin Georgescu, Jonathan D. Wren, Mark L. Lang, Etty N. Benveniste, Laurie E. Harrington, Leo Tsiokas, James F. George, Kenneth L. Jones, David K. Crossman, Anupam Agarwal, Michal Mrug, Bradley K. Yoder, Katharina Hopp, Kurt A. Zimmerman
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Inducible disruption of cilia-related genes in adult mice results in slowly progressive cystic disease, which can be greatly accelerated by renal injury. METHODS: To identify in an unbiased manner modifier cells that may be influencing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b68546a95ed560353a481fa4245dbfd
https://doi.org/10.1681/asn.2021030278
https://doi.org/10.1681/asn.2021030278
Publikováno v:
Schalm's Veterinary Hematology. :1043-1049
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788f47ca46a48f895fb0280171a90d03
https://doi.org/10.1002/9781119500537.ch116
https://doi.org/10.1002/9781119500537.ch116
Autor:
Kurt L. Zimmerman, David L. Panciera, Ina Hoeschele, W. Edward Monroe, Stephanie Michelle Todd, Stephen R. Werre, Tanya LeRoith, Kellie Fecteau, Bathilda B. Lake
Publikováno v:
Frontiers in Veterinary Science, Vol 5 (2018)
Scottish terriers (ST) frequently have increased serum alkaline phosphatase (ALP) of the steroid isoform. Many of these also have high serum concentrations of adrenal sex steroids. The study's objective was to determine the cause of increased sex ste
Externí odkaz:
https://doaj.org/article/aa089fe139c54a5cab5d5e98580448d4