Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Kurt A, Schalper"'
Autor:
Sneha Burela, Mengni He, Ioannis P. Trontzas, Niki Gavrielatou, Kurt A. Schalper, Solomon Langermann, Dallas B. Flies, David L. Rimm, Thazin N. Aung
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Basal Cell Adhesion Molecule (BCAM), a receptor for laminin subunit α5, plays a crucial role in the pathogenesis of various malignancies. Notably, evidence of hypermethylation at multiple immune checkpoints in patients with low BCAM express
Externí odkaz:
https://doaj.org/article/e06f9eb926d740f08bba636b5ace8940
Autor:
Charlie Garnett-Benson, Sarah Warren, Anne Monette, Alexandra Snyder, Janis M Taube, J Carl Barrett, Kurt A Schalper, Brian Topp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Therapies targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-L1) (abbreviated as PD-(L)1) axis are a significant advancement in the treatment of many tumor types. However, many patients receiving these agents fail to respond
Externí odkaz:
https://doaj.org/article/01ae6040ff4e401b8cab10bfcad5a0ee
Autor:
David L Rimm, Kurt A Schalper, Myrto K Moutafi, Ioannis A Vathiotis, Niki Gavrielatou, Katherine M Bates, Thazin Nwe Aung, Rolando Garcia Milian, Vasiliki Xirou, Athanasios Angelakis, Leonidas Salichos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)
Background Despite the impressive outcomes with immune checkpoint inhibitor (ICI) in non-small cell lung cancer (NSCLC), only a minority of the patients show long-term benefits from ICI. In this study, we used retrospective cohorts of ICI treated pat
Externí odkaz:
https://doaj.org/article/5c7458e2e485439097b4e6dbfd5e0655
Autor:
Ignacio Melero, Alvaro Teijeira, Kurt A Schalper, Carlos E De Andrea, Alvaro Lopez Janeiro, Eduardo Miraval Wong, Daniel Jiménez-Sánchez, Carlos Ortiz de Solorzano, Maria D Lozano
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Introduction The tissue immune microenvironment is associated with key aspects of tumor biology. The interaction between the immune system and cancer cells has predictive and prognostic potential across different tumor types. Spatially resolved tissu
Externí odkaz:
https://doaj.org/article/a78de50c324945a784d3648e434d4ee5
Autor:
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. McGee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if addi
Externí odkaz:
https://doaj.org/article/28952647439e48d680160b1ba89a37c4
Autor:
Sandra Martinez-Morilla, Myrto Moutafi, Aileen I. Fernandez, Shlomit Jessel, Prajan Divakar, Pok Fai Wong, Rolando Garcia-Milian, Kurt A. Schalper, Harriet M. Kluger, David L. Rimm
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTAlthough immune checkpoint inhibitor (ICI) therapy has dramatically improved outcome for metastatic melanoma patients, many patients do not benefit. Since adverse events may be severe, biomarkers for resistance would be valuable, especially i
Externí odkaz:
https://doaj.org/article/61850931c801456bb2e5a14b003e557a
Autor:
Rong Li, Francois Ghiringhelli, Antoine Italiano, Antoni Ribas, Paolo Antonio Ascierto, Michael Cecchini, Joseph Paul Eder, Kurt A Schalper, Sara I Pai, Mace Rothenberg, Ellen Pure, Wolf Herve Fridman, Fatima Mechta-Grigoriou, Guy Travis Clifton, Glenn Begley, Marina Kochetkova, Paolo Provenzano
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Checkpoint inhibitors represent an effective treatment approach for a variety of cancers through their inhibition of immune regulatory pathways within the tumor microenvironment (TME). Unfortunately only a minority of patients with cancer achieve cli
Externí odkaz:
https://doaj.org/article/3536fd9b7adb4dc68227628c4f9989e9
Autor:
Luis M Montuenga, Roy S Herbst, Luis Paz-Ares, David L Rimm, Kurt A Schalper, Alfonso Calvo, Myrto K Moutafi, Ioannis A Vathiotis, Magdalena Molero, Sandra Martinez Morilla, Javier Baena, Niki Gavrielatou, Laura Castro-Labrador, Gorka Ruiz de Garibay, Vera Adradas, Daniel Orive, Karmele Valencia, S Ponce Aix, Jon Zugazagoitia
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background Most patients with advanced non-small-cell lung cancer (NSCLC) fail to derive significant benefit from programmed cell death protein-1 (PD-1) axis blockade, and new biomarkers of response are needed. In this study, we aimed to discover and
Externí odkaz:
https://doaj.org/article/60a055bbf4cc41e595b426409dc06526
Autor:
Hongyu Zhao, Kurt A Schalper, Konstantinos Syrigos, Adam Aguirre-Ducler, Nicole Gianino, Franz Villarroel-Espindola, Shruti Desai, Daiwei Tang, William L Trepicchio, Karuppiah Kannan, Richard C Gregory
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background The expression of SYK in cancer cells has been associated with both tumor promoting and tumor suppressive effects. Despite being proposed as anticancer therapeutic target, the possible role of SYK in modulating local adaptive antitumor imm
Externí odkaz:
https://doaj.org/article/226cd00e288a459e9d9ceadc7c706a91
Autor:
Roy S Herbst, Lieping Chen, David L Rimm, Miguel F Sanmamed, Kurt A Schalper, Alice Li, Konstantinos Syrigos, Jovian Yu, Adam Aguirre-Ducler, Brian S Henick, Franz Villarroel-Espindola, Ila Datar, Shruti Desai
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Despite the prominent role of innate immunity in the antitumor response, little is known about the myeloid composition of human non-small cell lung cancer (NSCLC) with respect to histology and molecular subtype. We used multiplexed quantit
Externí odkaz:
https://doaj.org/article/8666dac9e47e49ac8886f836aa022847