Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Kurt Hertogs"'
Autor:
Els Pardon, Ulrich Rothbauer, Cécile Vincke, Heinrich Leonhardt, Inge Dierynck, Mireille Pellis, Joris Messens, J. Kinne, Kurt Hertogs, Katja Conrath, Kourosh Zolghadr, Serge Muyldermans
Publikováno v:
Archives of Biochemistry and Biophysics; Vol 526
Camel single-domain antibody fragments or Nanobodies, are practical in a wide range of applications. Their unique biochemical and biophysical properties permit an intracellular expression and antigen targeting. The availability of an efficient intrac
Autor:
Kurt Hertogs, R Pauwels, S. D. Kemp, Schlomo Staszewski, Veronica Miller, Martin Stürmer, Jingshan Ren, B. A. Larder, David I. Stuart, David K. Stammers, R. L. Desmet, Stuart Bloor
Publikováno v:
Scopus-Elsevier
To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c8f4e46ae7c1f82b43696643b47260
https://ora.ox.ac.uk/objects/uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
https://ora.ox.ac.uk/objects/uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
Autor:
Kurt Hertogs
Johnson & Johnson is engaged in a new strategy of partnering and cultivating external innovation that relies on strengthening the ecosystem for innovation in its areas of interest. Johnson & Johnson Innovation (JJI) has been implementing this strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4b79a39bd39637a8a55660f137fe555
Autor:
Olivia Goethals, Alfred M. Del Vecchio, Francois Nicol, Kurt Hertogs, Yuan Peng Zhang, Zheng Xu, Lester L. Gutshall, Tim Hugo Maria Jonckers, Reginald Clayton, Robert T. Sarisky, Asa Ohagen, Lieve Emma Jan Michiels, Sharon Bola, Haiyan Jiang, Marnix Van Loock, John Grigsby, Mark W. Cunningham
Publikováno v:
Antiviral Research. 84:142-149
Selective delivery of antiretrovirals to human immunodeficiency virus (HIV) infected cells may reduce toxicities associated with long-term highly active antiretroviral therapy (HAART), may improve therapeutic compliance and delay the emergence of res
Autor:
Marie-Pierre de Béthune, Said Oumouch, Patrice Palandjian, Jerome Emile Georges Guillemont, Daniel Vernier, Kurt Hertogs, Koen Andries, Chi Hung Nguyen, Laurence Queguiner, David S. Grierson, Abdellah Benjahad, Laurence F B Decrane
Publikováno v:
Journal of medicinal chemistry
A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones has been synthesized as new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient
Autor:
Elisabeth Wagemans, Kurt Hertogs, Inge Vereycken, Geert Meersseman, Kurt Vermeire, Koen Dockx, Olivia Goethals, Dominique Schols, Marcia Van Ginderen, Reginald Clayton, Sabine Hallenberger, Dirk Jochmans, Rudy Strijbos, Peggy Geluykens, Ann Vos, Veerle Smits
Publikováno v:
Journal of Virology. 82:10366-10374
Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by the viral integrase enzyme. The first generation of integrase inhibitors recently approved or currently in late-stage clini
Publikováno v:
Journal of Virological Methods. 151:121-125
The development of antiviral assays using an ATP/luminescence-based readout to profile antiviral compounds against the positive-strand RNA viruses: yellow fever virus (YFV), West Nile virus (WNV), Sindbis virus, and Coxsackie B virus, representing th
Autor:
Piet Wigerinck, Maryam Ehteshami, Jerome Deval, Bertrand Van Schoubroeck, Tania Ivens, Marcia Van Ginderen, Eva Bettens, Dirk Jochmans, Matthias Götte, Inky De Baere, Pascale Dehertogh, Kurt Hertogs, Bart Rudolf Romanie Kesteleyn, Herwig Van Marck
Publikováno v:
Journal of Virology. 80:12283-12292
We have discovered a novel class of human immunodeficiency virus (HIV) reverse transcriptase (RT) inhibitors that block the polymerization reaction in a mode distinct from those of the nucleoside or nucleotide RT inhibitors (NRTIs) and nonnucleoside
Autor:
Géry Dams, Rudi Pauwels, Kurt Hertogs, Christel Van den Eynde, Erik Nijs, Eva Bettens, Tania Ivens, Asa Ohagen, Koen Van Acker
Publikováno v:
Journal of Virological Methods
The severity and global spread of the 2003 outbreak of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) highlighted the risks to human health posed by emerging viral diseases and emphasized the need for specific therapeutic age
Publikováno v:
AIDS. 17:1897-1906
Objective: HIV-1 encephalopathy (HIVE) is associated with high levels of viral RNA in the central nervous system (CNS). Highly active antiretroviral therapy (HAART) effectively reduces HIV replication in both plasma and cerebrospinal fluid (CSF). Som