Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kurt, Lackovic"'
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Supplementary Table S1 - RT-PCR Primer sequences used in the study Supplementary Table S2 - CDK2 shRNA sequences used in the study Supplementary Table S3 - Cell lines and genes used in the analysis from Project Achilles Supplementary Table S4 - EC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2f3f3700ae0ac844eafb1c07c49660
https://doi.org/10.1158/1078-0432.22463450
https://doi.org/10.1158/1078-0432.22463450
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Purpose: Cyclin E1 (CCNE1) amplification is associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Here, we explore approaches to target CCNE1-amplified cancers and potential strategies to overcome r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d877fd05f018f7dc70d8439c9254b02b
https://doi.org/10.1158/1078-0432.c.6525410
https://doi.org/10.1158/1078-0432.c.6525410
Autor:
Carl R. Walkley, Kaylene J. Simpson, Michael A. Dyer, David C.S. Huang, Chris Burns, Andrew C.W. Zannettino, Piyush B. Madhamshettiwar, Jayesh Desai, Anthony J. Mutsaers, Åsa Karlström, Kurt Lackovic, Scott Taylor, Alistair M. Chalk, Cathryn M. Gould, Anang A. Shelat, Amos Loh, Elizabeth Stewart, Soo-San Wan, Emma K. Baker, Ankita Gupte
Purpose: Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significant improvements in patient survival have not been observed. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038b0bc2ae54a3ccfed107284bf17a8c
https://doi.org/10.1158/1078-0432.c.6523853.v1
https://doi.org/10.1158/1078-0432.c.6523853.v1
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Supplementary Figure S1 - Validation of CCNE1 and CDK2 siRNA-mediated knockdown Supplementary Figure S2 - Validation of CDK2 knockdown mediated by shRNA in vitro and in vivo Supplementary Figure S3 - FACS plots validating incorporation and induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c273b1d104ac9fa623318e8336c6e5e
https://doi.org/10.1158/1078-0432.22463456
https://doi.org/10.1158/1078-0432.22463456
Autor:
David D.L. Bowtell, Dariush Etemadmoghadam, Ronny Drapkin, Alison M. Karst, Danny Rischin, Linda Mileshkin, Richard B. Pearson, Carleen Cullinane, Diar Aziz, Kurt Lackovic, Kate E. Jarman, Chris Mitchell, Walid J. Azar, Franziska Lang, George Au-Yeung
Additional description of methods for gene suppression studies, Western blot, immunohistochemistry, flow cytometry and cellular assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c15f603f6dbc72a4e56b398a75b056
https://doi.org/10.1158/1078-0432.22463453
https://doi.org/10.1158/1078-0432.22463453
Autor:
Carl R. Walkley, Kaylene J. Simpson, Michael A. Dyer, David C.S. Huang, Chris Burns, Andrew C.W. Zannettino, Piyush B. Madhamshettiwar, Jayesh Desai, Anthony J. Mutsaers, Åsa Karlström, Kurt Lackovic, Scott Taylor, Alistair M. Chalk, Cathryn M. Gould, Anang A. Shelat, Amos Loh, Elizabeth Stewart, Soo-San Wan, Emma K. Baker, Ankita Gupte
Supplemental Material and Methods, Table 1, and Figures 1-7. Supplemental Table 1 - Primer Sequences used for qPCR. Supplemental Figure 1 - Suppressors of doxorubicin induced cell death from siRNA screen. Supplemental Figure 2 - Response to Spliceost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc1106dccb2b6c4fd3769199c668b33
https://doi.org/10.1158/1078-0432.22458170.v1
https://doi.org/10.1158/1078-0432.22458170.v1
Autor:
Christina B Wölwer, Luke B Pase, Helen B Pearson, Nathan J Gödde, Kurt Lackovic, David C S Huang, Sarah M Russell, Patrick O Humbert
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142655 (2015)
Erythroid enucleation is critical for terminal differentiation of red blood cells, and involves extrusion of the nucleus by orthochromatic erythroblasts to produce reticulocytes. Due to the difficulty of synchronizing erythroblasts, the molecular mec
Externí odkaz:
https://doaj.org/article/8f9a9667a206456992fa2baa9f936e6b
Autor:
Tony S Cardno, Yosuke Shimaki, Brad E Sleebs, Kurt Lackovic, John P Parisot, Rebecca M Moss, Caillan Crowe-McAuliffe, Suneeth F Mathew, Christina D Edgar, Torsten Kleffmann, Warren P Tate
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139036 (2015)
Frameshifting during translation of viral or in rare cases cellular mRNA results in the synthesis of proteins from two overlapping reading frames within the same mRNA. In HIV-1 the protease, reverse transcriptase, and integrase enzymes are in a secon
Externí odkaz:
https://doaj.org/article/20a5de53f7ec45b591411810ac7d69b1
Autor:
Mark F. van Delft, Meng Xiao Luo, Kate McArthur, Peter E. Czabotar, Jarrod J. Sandow, Laura F. Dagley, Kym N Lowes, Jason M. Brouwer, Andrew I. Webb, Guillaume Lessene, Rachael M. Lane, Keith G. Watson, Christoph Grohmann, Ahmad Wardak, Peter M. Colman, Sabrina Bernard, Soo San Wan, Yelena Khakham, Phillip P. Sharp, Romina Lessene, Thao Nguyen, David J. Segal, David C.S. Huang, Erinna F. Lee, Lucy Li, Marlyse A. Debrincat, Grant Dewson, Chinh T. Bui, Hui San Chin, W. Douglas Fairlie, Stephane Duflocq, Benjamin T. Kile, Stephane Chappaz, Caroline Miles, Kurt Lackovic, Laure Peilleron
Publikováno v:
Nature Chemical Biology. 15:1057-1066
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f8a84e9d19f8763b3963c4941664e3
https://doi.org/10.1038/s41589-019-0365-8
https://doi.org/10.1038/s41589-019-0365-8
Autor:
Keith G. Watson, Benny J. Evison, Brad E. Sleebs, Don R. Phillips, Jelena Medan, Suzanne M. Cutts, Kurt Lackovic
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
Current techniques for the identification of DNA adduct-inducing and DNA interstrand crosslinking agents include electrophoretic crosslinking assays, electrophoretic gel shift assays, DNA and RNA stop assays, mass spectrometry-based methods and 32P-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ae5ce5bb8656e0213c964940bc8181
https://pubmed.ncbi.nlm.nih.gov/33486050
https://pubmed.ncbi.nlm.nih.gov/33486050