DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer

Autor: Majid Momeny, Mari Tienhaara, Mukund Sharma, Deepankar Chakroborty, Roosa Varjus, Iina Takala, Joni Merisaari, Artur Padzik, Andreas Vogt, Ilkka Paatero, Klaus Elenius, Teemu D Laajala, Kari J Kurppa, Jukka Westermarck

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1603-1629 (2024)

Abstract Despite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer cells transitioning from dormant drug tole

Externí odkaz: https://doaj.org/article/709f9a596c0c46e4951cbcebf8781895

Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child

Autor: Anna, Eurén, Heikki, Hyöty, Kalle, Kurppa, Jutta, Laiho, Olli, Laitinen, Jussi, Lehtonen, Katri, Lindfors, Maria, Lönnrot, Johannes, Malkamäki, Noora, Nurminen, Matti, Nykter, Sami, Oikarinen, Leena, Puustinen, Amirbabak, Sioofy-Khojine, Keijo, Viiri, Daniel, Agardh, Andrén, Aronsson Carin, Markus, Lundgren, Iida, Mäkelä, Martin, Romantschuk, Laura, Soininen, Nicolai A, Lund-Blix, Maria, Magnus, Aino-Kaisa, Rantala, Lars, Stene, Ketil, Størdal, German, Tapia, Laura, Elo, Sini, Junttila, Riitta, Lahesmaa, Johanna, Lempainen, Robert, Moulder, Omid, Rasool, Tomi, Suomi, Jorma, Toppari, Ubaid, Ullah, Riitta, Veijola, Aleksandr, Peet, Kärt, Simre, Vallo, Tillmann, Elena, Bargagli, Francesco, Dotta, Laura, Nigi, Guido, Sebastiani, Leena, Hakola, Hannu, Kiviranta, Panu, Rantakokko, Suvi M, Virtanen, Ondrej, Cinek, Eva, Fronkova, Jaroslav, Havlik, Matthieu, Molinier, Juha, Pajula, Eija, Parmes, Juha, Pärkkä, Petri, Saviranta, Peter, Ylén, Alar, Aints, Anu, Bärenson, Anne, Kirss, Ivo, Laidmäe, Astrid, Oras, Aili, Tagoma, Raivo, Uibo, Tamara, Vorobjova, Loïc, Burr, Stefano, Cattaneo, Hui, Chai-Gao, Peter, Cristofollini, Silvia, Generelli, Samantha, Paoletti, Edith, Ruth, Gabriele, Berg, Wisnu, Wicaksono, Joseph, Petrosino, Rainer, Thiel, Schmidtmann, Daniel, Rosanna, Salo, Lauri, Häme, Alexander, Berler, Korina, Papadopoulou, Hans, Bisgaard, Klaus, Bonnelykke, Sarah, Brandt, Astrid, Sevelsted, Jakob, Stokholm, Jonathan, Thorsen, Mikael, Knip, Aki, Sinkkonen, Marja, Roslund, Hakola, Leena, Lund-Blix, Nicolai A., Takkinen, Hanna-Mari, Tapanainen, Heli, Niinistö, Sari, Korhonen, Tuuli E., Stene, Lars C., Hyöty, Heikki, Toppari, Jorma, Ilonen, Jorma, Knip, Mikael, Veijola, Riitta, Virtanen, Suvi M.

Publikováno v: In Clinical Nutrition ESPEN August 2024 62:22-27

Prevalence of vomiting and nausea and associated factors after chronic and acute gluten exposure in celiac disease

Autor: Iida Ahonen, Pilvi Laurikka, Sara Koskimaa, Heini Huhtala, Katri Lindfors, Katri Kaukinen, Kalle Kurppa, Laura Kivelä

Publikováno v: BMC Gastroenterology, Vol 23, Iss 1, Pp 1-10 (2023)

Abstract Background Vomiting and nausea seem to be relatively specific symptoms related to gluten ingestion in treated celiac disease. However, the overall prevalence and associated factors of these symptoms after chronic gluten exposure at celiac di

Externí odkaz: https://doaj.org/article/94269f493fe549e5aacea47e07924360

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IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease

Autor: Vatta Serena, Not Tarcisio, Paavola-Sakki Paulina, Halme Leena, Turunen Ulla, Färkkilä Martti, Széles György, Pocsai Zsuzsa, Ádány Róza, Kaukinen Katri, Kurppa Kalle, Korponay-Szabo Ilma R, Ziberna Fabiana, Lappalainen Maarit, Suomela Sari, Kainu Kati, Dukes Emma, Koskinen Lotta LE, Einarsdottir Elisabet, Ventura Alessandro, Löfberg Robert, Torkvist Leif, Bresso Francesca, Halfvarson Jonas, Mäki Markku, Kontula Kimmo, Saarialho-Kere Ulpu, Kere Juha, D'Amato Mauro, Saavalainen Päivi

Publikováno v: BMC Medical Genetics, Vol 10, Iss 1, p 8 (2009)

Abstract Background Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for m

Externí odkaz: https://doaj.org/article/4dac4003b1f14234963aa3368b956040