Výsledky vyhledávání - "Kuppusamy Sankar"

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Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

Autor: Manuela M. Brütsch, Dale L. Boger, Daniel M. Brody, Colin K. Skepper, Timothy J. Barker, John C. Lukesh, Shouliang Yang, Kuppusamy Sankar

Publikováno v: Chemical Science. 8:1560-1569

The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f5520d2ace94d01296e9782792efaaf
https://doi.org/10.1039/c6sc04146a

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Akademický článek

Total Synthesis of the 7,10-Epimer of the Proposed Structure of Amphidinolide N, Part I: Synthesis of the C1-C13 Subunit.

Autor: Ochiai, Koji¹, Kuppusamy, Sankar¹, Yasui, Yusuke¹, Okano, Tsubasa¹, Matsumoto, Yasunobu¹, Gupta, Nishant R.¹, Takahashi, Yohei², Kubota, Takaaki^2,3, Kobayashi, Jun'ichi², Hayashi, Yujiro^1,4

Publikováno v: Chemistry - A European Journal. Mar2016, Vol. 22 Issue 10, p3282-3286. 5p.

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Akademický článek

Total Synthesis of the 7,10-Epimer of the Proposed Structure of Amphidinolide N, Part II: Synthesis of C17-C29 Subunit and Completion of the Synthesis.

Autor: Ochiai, Koji¹, Kuppusamy, Sankar¹, Yasui, Yusuke¹, Harada, Kenji¹, Gupta, Nishant R.¹, Takahashi, Yohei², Kubota, Takaaki^2,3, Kobayashi, Jun'ichi², Hayashi, Yujiro^1,4

Publikováno v: Chemistry - A European Journal. Mar2016, Vol. 22 Issue 10, p3287-3291. 5p.

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Transannular Diels–Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Total Synthesis of a Unique Set of Vinblastine Analogues

Autor: Katharine K. Duncan, Colin K. Skepper, Dale L. Boger, Kuppusamy Sankar, Erica L. Campbell

Publikováno v: Organic Letters. 15:5306-5309

A powerful tandem [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazoles initiated by a transannular [4 + 2] cycloaddition is detailed. An impressive four rings, four carbon-carbon bonds, and six stereocenters are set on each site of the newly fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058f42f83c2f6796e80539aa885141ce
https://doi.org/10.1021/ol402549n

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Carbohydrate templates for the synthesis of prototype renin inhibitors

Autor: Debendra K. Mohapatra, Kuppusamy Sankar, Gokarneswar Sahoo, Mukund K. Gurjar

Publikováno v: Tetrahedron: Asymmetry. 19:2123-2129

A concise synthesis of a prototype renin inhibitor and its 7-epimer has been accomplished starting from readily available d -glucose.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db7a5fa3bcee5e1586a99c3acb7fe288
https://doi.org/10.1016/j.tetasy.2008.08.007

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Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

Autor: Hideaki Kakeya, Kazutoshi Mizoue, Kuppusamy Sankar, Yuriko Nozawa, Hayato Ishikawa, Yujiro Hayashi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:3863-3865

The first asymmetric total synthesis of FD-838, a naturally occurring azaspirobicyclic product, has been accomplished allowing determination of its absolute stereochemistry.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b532e50af3d82635493c4e8d18604e1
https://doi.org/10.1016/j.bmcl.2009.03.154

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ChemInform Abstract: Organocatalytic, Enantioselective Intramolecular [6 + 2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on Its Mechanism from a Computational Study

Autor: Seiji Tsuzuki, Indresh Kumar, Hiroharu Yui, Masakazu Honma, Kohzo Konno, Tadafumi Uchimaru, Hayato Ishikawa, Yujiro Hayashi, Kuppusamy Sankar, Hiroaki Gotoh

Publikováno v: ChemInform. 43

Diphenylprolinol silyl ether was found to be an effective organocatalyst for promoting the asymmetric, catalytic, intramolecular [6 + 2] cycloaddition reactions of fulvenes substituted at the exocyclic 6-position with a δ-formylalkyl group to afford

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84c02062c01cdc561b5b41ccb44d775d
https://doi.org/10.1002/chin.201220022

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Practical syntheses of proposed and revised manzacidin B and their congeners

Autor: Hasibur Rahman, Balasubramanian Sridhar, Pragna P. Das, Debendra K. Mohapatra, Eswar Bhimireddy, Kuppusamy Sankar

Publikováno v: Organic letters. 14(4)

A concise and highly stereoselective total synthesis of manzacidin B and its congeners has been developed following chelation-controlled syn-epoxidation and Lewis acid catalyzed intramolecular regioselective epoxide ring opening to generate the quart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abbe9672fcb70a5e5c6f54a1e46ef4c
https://pubmed.ncbi.nlm.nih.gov/22315965

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