Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Kuppan, Gokulan"'
Autor:
Mohamed Lahiani, Kuppan Gokulan, Vicki Sutherland, Helen C. Cunny, Carl E. Cerniglia, Sangeeta Khare
Publikováno v:
Journal of Xenobiotics, Vol 14, Iss 1, Pp 193-213 (2024)
Triclosan (TCS), a broad-spectrum antibacterial chemical, is detected in human urine, breast milk, amniotic fluid, and feces; however, little is known about its impact on the intestinal microbiome and host mucosal immunity during pregnancy and early
Externí odkaz:
https://doaj.org/article/589e39325a314596b6fb4969ace900ec
Autor:
Chandra Mohan Reddy Muthumula, Sangeeta Khare, Rajan Jog, Bhagya Wickramaratne, Angela Lee, Sushanta Chakder, Diane J. Burgess, Kuppan Gokulan
Publikováno v:
International Journal of Pharmaceutics: X, Vol 7, Iss , Pp 100254- (2024)
Zileuton is a leukotriene inhibitor used to treat asthma. As a BCS class II drug it exhibits challenges with solubility which likely impact its absorption. As patient gender significantly impacts the pharmacokinetics of many drugs, this study aimed t
Externí odkaz:
https://doaj.org/article/ca5d7c5018614b929a1228ec84e302d8
Autor:
Koonce, Nathan A., Mathew, Ammu, Popescu, Ioana-Mihaela, Davis, Kelly, Wagner, Doug, Kuppan, Gokulan, Manjanatha, Mugimane, Leakey, Julian E.A., Patri, Anil K.
Publikováno v:
In NanoImpact October 2024 36
Publikováno v:
Frontiers in Artificial Intelligence, Vol 5 (2022)
Bacterial species have evolved with a wide variety of cellular devices, and they employ these devices for communication and transfer of genetic materials and toxins. They are classified into secretory system types I to VI based on their structure, co
Externí odkaz:
https://doaj.org/article/a95ab18e035e48df9bd982810d265e8f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6352 (2023)
First-pass metabolism alters arsenic biotransformation and its immunomodulatory activities. This study aims to determine the mRNA expression of intestinal-immunity- and permeability-associated genes, levels of cytokine/chemokines and levels of immuno
Externí odkaz:
https://doaj.org/article/fc0918d9a4224d9da68b22d8b3fa14a6
Publikováno v:
Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Silver ions from silver nanoparticles (AgNP) or AgNPs themselves itself that are ingested from consumer health care products or indirectly from absorbed food contact material can interact with the gastrointestinal tract (GIT). The
Externí odkaz:
https://doaj.org/article/2d070f33c2fc49be9af689ea0d86ebd3
Publikováno v:
Frontiers in Artificial Intelligence, Vol 4 (2021)
COVID-19, the illness caused by the SARS-CoV-2 virus, is now a worldwide pandemic with mortality in hundreds of thousands as infections continue to increase. Containing the spread of this viral infection and decreasing the mortality rate is a major c
Externí odkaz:
https://doaj.org/article/c43bd3b395494891a854c24718b90248
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4851 (2022)
The gastrointestinal tract (GIT) is exposed to xenobiotics, including drugs, through both: local (oral) and systemic routes. Despite the advances in drug discovery and in vitro pre-clinical models, there is a lack of appropriate translational models
Externí odkaz:
https://doaj.org/article/16c61aa8ab564e8fb634a1445af700c1
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Trichloroethylene (TCE) is a common environmental toxicant linked with hypersensitivity and autoimmune responses in humans and animal models. While autoimmune diseases are more common in females, mechanisms behind this disparity are not clear. Recent
Externí odkaz:
https://doaj.org/article/410467e55ed744cbb088166813af5a5a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11443 (2021)
Toxicology studies on pristine graphene are limited and lack significant correlations with actual human response. The goal of the current study was to determine the response of total colonic human tissue to pristine graphene exposure. Biopsy punches
Externí odkaz:
https://doaj.org/article/f7e398b354564c768360f97f7975b341