Zobrazeno 1 - 10 of 164 pro vyhledávání: '"Kuper, C.F."'
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3
Kniha
11.15 - Lymphoid Tissue and Pathological Influences of Toxicants
Autor: Schaudien, D., Harleman, J.H., Bouallala, F., Kuper, C.F.
Publikováno v: In Comprehensive Toxicology Edition: Third Edition. 2018:322-342
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4
A practical approach to assess inhalation toxicity of metal oxide nanoparticles in vitro
Autor: Dankers, A.C.A., Kuper, C.F., Boumeester, A.J., Fabriek, B.O., Kooter, I.M., Gröllers-Mulderij, M., Tromp, P., Nelissen, I., Zondervan-Van Den Beuken, E.K., Vandebriel, R.J.
Publikováno v: Journal of Applied Toxicology, 2, 38, 160-171
Exposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled metal oxide NPs may generate inflammation. The aim of this study was to investigate the proinflammatory potential of six metal oxide NPs (CeO2, Mn2O3, CuO, ZnO,
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5
The serosal immune system of the thorax in toxicology
Autor: Kuper, C.F., Bilsen, J. van, Wijnands, M.V.W.
Publikováno v: Toxicological Sciences, 1, 164, 31-38
The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal imm
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6
Akademický článek
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7
Factors of concern in a human 3D cellular airway model to aerosols of nanoparticles
Autor: Kooter, I.M., Grollers-Mulderij, M., Duistermaat, E., Kuper, C.F.
Publikováno v: Toxicology in vitro, 44, 339-348
Mucilair 3D bronchial airway models, cultured at an air-liquid interface, were exposed to aerosols of copper oxide (CuO) nanoparticles in Vitrocell air exposure modules. Four cell donors, four exposure modules and four exposure concentrations were va
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8
Development of immune organs and functioning in humans and testanimals: Implications for immune intervention studies
Autor: Kuper, C.F., Bilsen, J. van, Cnossen, H., Houben, G., Garthoff, J., Wolterbeek, A.
Publikováno v: Reproductive Toxicology, 64, 180–190
Ahealthyimmunestatus is mostly determined during early life stages andmanyimmune-related diseases may find their origin in utero and the first years of life. Therefore, immune health optimization may be most effective during early life. This review i
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9
Feasibility of a 3D human airway epithelial model to study respiratory absorption
Autor: Reus, A.A., Maas, W.J.M., Jansen, H.T., Constant, S., Staal, Y.C.M., Triel, J.J. van, Kuper, C.F.
Publikováno v: Toxicology in vitro, 2, 28, 258-264
The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety an
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10
The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab
Autor: Mierlo, G.J.D. van, Cnubben, N.H.P., Wouters, D., Wolbink, G.J., Hart, M.H.L., Rispens, T., Ganderup, N.C., Kuper, C.F., Aarden, L., Penninks, A.H.
Publikováno v: Journal of Immunotoxicology, 1, 11, 62-71
Immunogenicity is a major issue of concern for monoclonal antibodies used in human diseases and is by default mainly determined in non-human primates (NHP), as target molecules are considered most similar in NHP compared to human. In this manuscript
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