An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut.

Autor: Nan K; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. knan@zju.edu.cn.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. knan@zju.edu.cn.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. knan@zju.edu.cn., Wong K; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Li D; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.; Hong Kong Center for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong SAR, China., Ying B; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., McRae JC; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Feig VR; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wang S; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Du N; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, China., Liang Y; Department of General Surgery, Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Mao Q; Department of General Surgery, Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Zhou E; Department of General Surgery, Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China., Chen Y; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sang L; School of Microelectronics, Hefei University of Technology, Hefei, 230601, China., Yao K; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China., Zhou J; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.; Hong Kong Center for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong SAR, China., Li J; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China.; Hong Kong Center for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong SAR, China., Jenkins J; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ishida K; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kuosmanen J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Mohammed Madani WA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Hayward A; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA., Ramadi KB; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Engineering, New York University Abu Dhabi, Abu Dhabi, UAE.; Tandon School of Engineering, New York University, New York, NY, USA., Yu X; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, China. xingeyu@cityu.edu.hk.; Hong Kong Center for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong SAR, China. xingeyu@cityu.edu.hk., Traverso G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. cgt20@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, USA. cgt20@mit.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 08; Vol. 15 (1), pp. 6749. Date of Electronic Publication: 2024 Aug 08.

An ingestible self-propelling device for intestinal reanimation.

Autor: Srinivasan SS; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dosso J; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Huang HW; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Selsing G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Alshareef A; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kuosmanen J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ishida K; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Jenkins J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Madani WAM; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hayward A; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Traverso G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Publikováno v: Science robotics [Sci Robot] 2024 Feb 28; Vol. 9 (87), pp. eadh8170. Date of Electronic Publication: 2024 Feb 28.

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Sub-1.4 cm3capsule for detecting labile inflammatory biomarkers in situ

Autor: Inda-Webb, M. E., Jimenez, M., Liu, Q., Phan, N. V., Ahn, J., Steiger, C., Wentworth, A., Riaz, A., Zirtiloglu, T., Wong, K., Ishida, K., Fabian, N., Jenkins, J., Kuosmanen, J., Madani, W., McNally, R., Lai, Y., Hayward, A., Mimee, M., Nadeau, P., Chandrakasan, A. P., Traverso, G., Yazicigil, R. T., Lu, T. K.

Publikováno v: Nature; August 2023, Vol. 620 Issue: 7973 p386-392, 7p

Bioinspired, ingestible electroceutical capsules for hunger-regulating hormone modulation.

Autor: Ramadi KB; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Engineering, New York University Abu Dhabi, Abu Dhabi, UAE.; Tandon School of Engineering, New York University, New York, NY 11201, USA., McRae JC; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Selsing G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Su A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fernandes R; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hickling M; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Rios B; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Babaee S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Min S; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Gwynne D; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Jia NZ; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Aragon A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ishida K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kuosmanen J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Jenkins J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hayward A; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kamrin K; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Traverso G; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Publikováno v: Science robotics [Sci Robot] 2023 Apr 26; Vol. 8 (77), pp. eade9676. Date of Electronic Publication: 2023 Apr 26.