Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Kuo-Sen Huang"'
Autor:
Eva S. Istvan, Francisco Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Pasaje, Krittikorn Kumpornsin, Madeline R. Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G. Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin Niles, Marcus C. S. Lee, Manuel Llinas, Nobutaka Kato, John Okombo, David A. Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E. Goldberg, Elizabeth A. Winzeler
Publikováno v:
Science Translational Medicine. 15
Development of antimalarial compounds into clinical candidates remains costly and arduous without detailed knowledge of the target. As resistance increases and treatment options at various stages of disease are limited, it is critical to identify mul
Autor:
Binbin Liu, Bruce Fahr, Kuo-Sen Huang, Anna M. Puzio-Kuter, Melissa Dumble, Dafydd G. Thomas, Hong Yang, Lizhong Xu, Kimberly Robell, Thomas P. Davis, Romyr Dominique, Binh Vu, Mary-Kate McBrayer, Chris Mulligan, Brandon Russo, Hongju Li
Publikováno v:
Cancer Research. 81:LB006-LB006
Mutations in the TP53 gene are the most frequent somatic alterations in human cancer; approximately 50% of all human cancers possess mutations in TP53. Missense mutations in TP53 which result in a non-functional protein are the most frequently identi
Autor:
Charles Wartchow, Julie DeMartino, David Robert Bolin, Gang Lu, Dan Li, Su Song, Chia Chi Sun, Lena Liang, Dinesh Srinivasan, Kuo-Sen Huang, Jaspreet Banga, Michelle Downing, Nader Fotouhi, Betsy J. Barnes, Cherrie D. Thompson, Hong Qian, Ann F. Hoffman, Seng-Lai Tan, Qin Guo, Yajuan Gu Qin, Jin Qiu, Francesca Milletti, Satwant K. Narula, Bharati Matta, Gang Chen, Margaret LaPan, Shannon Hamilton
Publikováno v:
Science Advances
The rational targeting of a transcription factor, interferon regulatory factor 5 (IRF5), inhibits downstream functions.
The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream
The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream
Autor:
Haoshuang Zhao, Naoko Tanaka, Wei Chu, Ueli Gubler, Michael Sabio, Sid Topiol, Peter Tolias, Kuo-Sen Huang
Publikováno v:
Medical Research Archives. 8
By analyzing KRas and HRas X-ray structures, we developed a novel strategy that involves the design of a series of “synthetic” or “artificial” KRas mutations, namely T20I, D57E, D57F, T58A, T58V, and G60A, individually introduced into KRas wi
Autor:
Daisy Carvajal, Ann C. Petersen, Cheryl Janson, Wei He, Javier de Vicente, Hong Qian, Christine Lukacs, Lin Yi, Kuo-Sen Huang, Johannes C. Hermann, Yong Zhuang, David Robert Bolin, Pamela Berry, Lena Liang, Parcharee Tivitmahaisoon
Publikováno v:
ACS Medicinal Chemistry Letters. 6:1019-1024
Tankyrase activity has been linked to the regulation of intracellular axin levels, which have been shown to be crucial for the Wnt pathway. Deregulated Wnt signaling is important for the genesis of many diseases including cancer. We describe herein t
Autor:
Shanshan Duan, Leslie I. Gold, John K. Dickson, Nadim Shohdy, Xinyan Huang, Miguel A. Manzanares, Julien Dubrulle, Yunfeng Li, Mirco Meniconi, Bing Hao, Michael A. Mancini, Michelle Pagano, Chinaza Egbuta, Kuo-sen Huang, Ana Tellechea
Publikováno v:
Cancer Research. 78:5231-5231
We have previously shown that ubiquitin-mediated degradation of the cyclin-dependent kinase inhibitor, p27kip1 (p27), critical for G1 arrest, is involved in the pathogenesis of Type I endometrial cancer (ECA; 80% of ECAs), which is estrogen (E2) indu
Autor:
Paul Gillespie, Yimin Qian, Tsutomu Sato, Kuo-Sen Huang, Xiaolei Zhang, Weiya Yun, Andrée R. Olivier, Karin Conde-Knape, Stuart Hayden, Qing Xiang, David Robert Bolin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2936-2940
Glycogen synthase (GS) catalyzes the transfer of glucose residues from UDP-glucose to a glycogen polymer chain, a critical step for glucose storage. Patients with type 2 diabetes normally exhibit low glycogen levels and decreased muscle glucose uptak
Autor:
Kuo-Sen Huang, Paola Di Lello, Sung-Sau So, David C. Fry, Peter Mohr, Martin Stahl, Harald Mauser, Klaus Müller, Takeo Harada, Binh Thanh Vu
Publikováno v:
ChemMedChem. 8:726-732
TARGETING PPIS: A novel strategy for designing libraries targeting protein-protein interfaces enabled us to identify diverse chemical entry points to interact with therapeutic targets for which conventional screening libraries delivered no or only fe
Autor:
Kuo-Sen Huang, Joseph A. Sergi, Stuart Hayden, Yonglin Ren, Weiya Yun, Qing Xiang, Mei Liu, Andrée R. Olivier, Yimin Qian, Karin Conde-Knape, Lin Yi, Xiaolei Zhang, David Robert Bolin, Paul Gillespie
Publikováno v:
MedChemComm. 4:833-838
Decreased glycogen synthesis and turnover is a common defect in type 2 diabetic patients. Activating glycogen synthase, the enzyme that catalyses the transfer of glucose from UDP-glucose to a glycogen polymer chain, could be a potential therapeutic t
Autor:
Johannes Auer, Patrick Cramer, Alvin S. Stern, Ulrich Kohnert, Packman Kathryn E, Ueli Gubler, Martin Lanzendörfer, Silke Hansen, Guy Georges, Klaus Kaluza, Dirk Kostrewa, Stefan Ries, Kuo‑Sen Huang, Christiane Hartl, Tobias Koschubs, Stefan Jennewein, Olaf Mundigl, Stefan Dengl, Harald Dürr
Publikováno v:
Biochemical Journal
Hepsin is a type II transmembrane serine protease that is expressed in several human tissues. Overexpression of hepsin has been found to correlate with tumour progression and metastasis, which is so far best studied for prostate cancer, where more th