A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarate.

Autor: Kuo-Hsiung Yang, Craig Hendrix, Namandje Bumpus, Julie Elliott, Karen Tanner, Christine Mauck, Ross Cranston, Ian McGowan, Nicola Richardson-Harman, Peter A Anton, Angela D M Kashuba

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e106196 (2014)

This Phase 1, randomized, two-site (United States), double-blind, placebo-controlled study enrolled 18 sexually abstinent men and women. All received a single 300-mg dose of oral tenofovir disoproxil fumarate (TDF) and were then randomized 2:1 to rec

Externí odkaz: https://doaj.org/article/9f2b358de802411cacb2075532cf09b7

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis

Autor: Angela D. M. Kashuba, Milena Veselinovic, Kuo Hsiung Yang, Leila Remling-Mulder, Ramesh Akkina, Craig Sykes

Publikováno v: Virology. 489:173-178

Orally administered anti-retroviral drugs show considerable promise for HIV/AIDS pre-exposure prophylaxis (PrEP). For the success of these strategies, pharmacokinetic (PK) data defining the optimal concentration of the drug needed for protection in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfab8beceb32aad32c2af7e51af6f9a

Pharmacodynamic Variability beyond That Explained by MICs

Autor: Alan Forrest, Brian T. Tsuji, G.V.N. Rao, Kuo-Hsiung Yang, Rachel L. Soon, Lance Wollenberg, Neang S. Ly

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:1730-1735

Monte Carlo simulations (MCS) present a powerful tool to evaluate candidate regimens by determining the probability of target attainment. Although these assessments have traditionally incorporated variability in pharmacokinetic (PK) parameters and MI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4157243b6755b6e27adac0c16e90f4dd
https://doi.org/10.1128/aac.01224-12

Genital tenofovir concentrations correlate with protection against HIV infection in the CAPRISA 004 trial: Importance of adherence for microbicide effectiveness

Autor: Nicole White, Lise. Werner, Salim S. Abdool Karim, Tanuja N. Gengiah, Angela D. M. Kashuba, Kuo-Hsiung. Yang, Quarraisha Abdool Karim

The CAPRISA 004 trial showed that coitally dosed tenofovir 1% gel reduced HIV acquisition by 39% overall and 54% when used consistently. The objective of this analysis was to ascertain its pharmacokinetic-pharmacodynamic relationship to protect again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972e282e553965e93ea9cf045cd3d6ca
https://europepmc.org/articles/PMC4505741/

HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat

Autor: Rosalie Bateson, John M. Coffin, Manoj K. Tripathy, Amanda M. Crooks, Joseph J. Eron, Angela D. M. Kashuba, Joann D. Kuruc, Douglas D. Richman, Elizabeth M. Anderson, Noelle P. Dahl, Kuo Hsiung Yang, Ronald J. Bosch, Matthew C. Strain, Mary F. Kearney, Kevin Robertson, Daria J. Hazuda, Nancy M. Archin, David M. Margolis

Publikováno v: Archin, Nancy M; Bateson, Rosalie; Tripathy, Manoj K; Crooks, Amanda M; Yang, Kuo-Hsiung; Dahl, Noelle P; et al.(2014). HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat.. The Journal of infectious diseases, 210(5), 728-735. doi: 10.1093/infdis/jiu155. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/0rd3381n
The Journal of infectious diseases, vol 210, iss 5

Effective antiretroviral therapy allows human immunodeficiency virus (HIV)–infected individuals to live long and productive lives [1]. However, HIV infection remains incurable in part owing to the presence of quiescent, replication-competent provir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f635b38eb9547e9df8d39e8322a0ef8e
http://www.escholarship.org/uc/item/0rd3381n