Zobrazeno 1 - 10
of 1 136
pro vyhledávání: '"Kuo-Hsiung Lee"'
Autor:
Saidanxia Amuti, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Publikováno v:
Molecules, Vol 29, Iss 3, p 651 (2024)
Eight vilasinin-class limonoids, including the unusually chlorinated rubescins K–M (1–3), the 2,3-epoxylated rubescin N (4), and rubescins O–R (5–8), were newly isolated from Trichilia rubescens. The structures of the isolated compounds were
Externí odkaz:
https://doaj.org/article/73427dc785014662bb22d080535fb349
Publikováno v:
Molecules, Vol 27, Iss 15, p 5029 (2022)
C4 variation of 4′-O-demethyl-epipodophyllotoxin (DMEP) is an effective approach to optimize the antitumor spectra of this compound class. Accordingly, two series of novel DMEP derivatives were synthesized, and as expected, the antitumor spectra of
Externí odkaz:
https://doaj.org/article/77d5561467a94d99889d02b91d0ecf27
Autor:
Ying-Tzu Chang, Yu-Ning Teng, Kun-I Lin, Charles C. N. Wang, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Chin-Chuan Hung
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR
Externí odkaz:
https://doaj.org/article/aadb4fb6502e4754853b555fcbdbf894
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-9 (2019)
Abstract Background The general approach to the synthesis of metal complexes begins with ligand synthesis, followed by ligand reaction with metal salts to afford organometallic complexes. Our research group first reported a one-pot multicomponent syn
Externí odkaz:
https://doaj.org/article/4cfb0e52633d461b8ef17b3be55e80b7
Publikováno v:
BMC Chemistry, Vol 13, Iss 1, Pp 1-3 (2019)
Following publication of the original article [1], the authors reported an error in Schemes 1 and 2 and repeated line in subsection “Bis(ligand) nickel(II) chelate (NiL1 2 )”.
Externí odkaz:
https://doaj.org/article/dbe5c959a22a4bc8b91f5e9b5e6353e8
Autor:
Biljana Cvetanova, Meng-Yi Li, Chung-Chih Yang, Pei-Wen Hsiao, Yu-Chih Yang, Jia-Hua Feng, Ya-Ching Shen, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3226 (2021)
Melanoma is a highly metastatic disease with an increasing rate of incidence worldwide. It is treatment refractory and has poor clinical prognosis; therefore, the development of new therapeutic agents for metastatic melanoma are urgently required. In
Externí odkaz:
https://doaj.org/article/c624358825684a9492e133d2332c5d2f
Autor:
Der-Yen Lee, Yu-Chi Hou, Jai-Sing Yang, Hui-Yi Lin, Tsu-Yuan Chang, Kuo-Hsiung Lee, Sheng-Chu Kuo, Min-Tsang Hsieh
Publikováno v:
Molecules, Vol 25, Iss 3, p 479 (2020)
Compound 1 is a curcumin di-O-2,2-bis(hydroxymethyl)propionate that shows significant in vitro and in vivo inhibitory activity against MDA-MB-231 cells with eight to ten-fold higher potency than curcumin. Here, we modified the α-position (C-4 positi
Externí odkaz:
https://doaj.org/article/fe2a24688e6b4f0b8dee0f3739064ea8
Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation
Autor:
Jing-Hua Yang, Xin-Yi Wang, Yi-Ping Zhou, Rong Lu, Chin-Ho Chen, Meng-Han Zhang, Yung-Yi Cheng, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Yun-Song Wang
Publikováno v:
Molecules, Vol 25, Iss 1, p 99 (2019)
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3−8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1−8) were evaluated for their
Externí odkaz:
https://doaj.org/article/5078149e12074ed18eaf8c0f7e0adfeb
Autor:
Simayijiang Aimaiti, Yohei Saito, Shuichi Fukuyoshi, Masuo Goto, Katsunori Miyake, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Publikováno v:
Molecules, Vol 24, Iss 21, p 4005 (2019)
Seven new butanolides, peltanolides A−G (1−7), and two lignan glucosides, peltasides A (8) and B (9), along with eleven known compounds, 10−20, were isolated from a crude CH3OH/CH2Cl2 (1:1) extract of the fruit of Hernandia nymphaeifolia (Herna
Externí odkaz:
https://doaj.org/article/7bc9410cae0142c4be269560e7d20552
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
A novel plant sesquiterpene lactone derivative, DET derivative (DETD)-35, originating from parental deoxyelephantopin (DET) was previously observed to effectively suppress human triple negative breast cancer (TNBC) MDA-MB-231 cell activity and tumor
Externí odkaz:
https://doaj.org/article/d6a2cbc4f62747d8bd283029b803dfb6