Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Kuo Kuang Wen"'
Autor:
Seong-Su Han, Kuo-Kuang Wen, María L. García-Rubio, Marc S. Wold, Andrés Aguilera, Wojciech Niedzwiedz, Yatin M. Vyas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancer develops in Wiskott-Aldrich syndrome (WAS). Here the authors identify a role for WAS-protein (WASp) in the DNA stress-resolution pathway by promoting the function of Replication Protein A at replication forks after DNA damage.
Externí odkaz:
https://doaj.org/article/6e499727fe454b339e1196dece4c37d7
Autor:
Jadwiga Nieminuszczy, Peter R Martin, Ronan Broderick, Joanna Krwawicz, Alexandra Kanellou, Camelia Mocanu, Vicky Bousgouni, Charlotte Smith, Kuo-Kuang Wen, Beth L Woodward, Chris Bakal, Fiona Shackley, Andrés Aguilera, Grant S Stewart, Yatin M Vyas, Wojciech Niedzwiedz
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication forks. These responses rely on the formation of Replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5531b5742effadd75fbaf524f41866e4
https://doi.org/10.1101/2023.01.12.523639
https://doi.org/10.1101/2023.01.12.523639
Publikováno v:
J Allergy Clin Immunol
Background Wiskott-Aldrich syndrome (WAS) is an X-linked primary immune deficiency disorder resulting from Wiskott-Aldrich syndrome protein (WASp) deficiency. Lymphocytes from patients with WAS manifest increased DNA damage and lymphopenia from cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad68f19a35bce17696e9971b5c750f63
https://doi.org/10.1016/j.jaci.2019.09.026
https://doi.org/10.1016/j.jaci.2019.09.026
Autor:
Yiyang Li, Wei Zhou, Xiangbing Meng, Sarina D. Murray, Long Li, Abby Fronk, Vanessa J. Lazaro-Camp, Kuo-kuang Wen, Meng Wu, Adam Dupuy, Kimberly K. Leslie, Shujie Yang
Publikováno v:
Cancers; Volume 14; Issue 19; Pages: 4883
Expression of progesterone receptor (PR) is a favorable prognostic marker for multiple solid tumors. However, PR expression is reduced or lost in malignant tumors. Thus, monitoring and restoring functional PR expression is important in order to sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ac1c8b96d7096d75d131b09481e553
https://doi.org/10.3390/cancers14194883
https://doi.org/10.3390/cancers14194883
A 'failed' assay development for the discovery of rescuing small molecules from the radiation damage
Publikováno v:
SLAS Discov
With improving survival rate for the cancer patients, the side effects of radiation therapy, especially for pediatric or more sensitive adult patients, have raised interests for preventive or rescuing treatment to overcome the detrimental effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18c1dfafc21b6d88d4beedf8636ef03
https://europepmc.org/articles/PMC8612958/
https://europepmc.org/articles/PMC8612958/
Autor:
Kelli L. Goss, Peter M. Gordon, Kuo Kuang Wen, William W. Terry, Torin Waters, Jason Ostergaard, David Gordon, Meng Wu, Stacia L. Koppenhafer
Publikováno v:
Oncogene
Ribonucleotide reductase (RNR), which is a heterodimeric tetramer composed of RRM1 and RRM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleoside triphosphates (dNTPs) and essential for both DNA replication and the repair of D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe3fc3ee2ddc9aca2bc9f181ac25c3d
https://pubmed.ncbi.nlm.nih.gov/33191406
https://pubmed.ncbi.nlm.nih.gov/33191406
Publikováno v:
Oncogene
Immunodeficiency is associated with cancer risk. Accordingly, hematolymphoid cancers develop in Wiskott-Aldrich syndrome (WAS), an X-linked primary immunodeficiency disorder (PID) resulting from the deficiency of WAS-protein (WASp) expressed predomin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0eb0e4014877efc6d0a51701ca80d1d
https://pubmed.ncbi.nlm.nih.gov/33139832
https://pubmed.ncbi.nlm.nih.gov/33139832
Autor:
Xiuying Liu, Meng Wu, Robert F. Mullins, Elliott H. Sohn, Shemin Zeng, Edwin M. Stone, Grefachew Workalemahu, Kathleen R. Chirco, Miles J. Flamme-Wiese, Budd A. Tucker, Kuo-Kuang Wen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
Age-related macular degeneration (AMD) is a common, blinding disease associated with increased complement system activity. Eyes with AMD show elevated accumulation of the membrane attack complex (MAC) in the choriocapillaris and degeneration of macul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65bec894f2dbc69e36d07667945493c
http://link.springer.com/article/10.1038/s41598-018-31846-z
http://link.springer.com/article/10.1038/s41598-018-31846-z
Autor:
Thomas Bartman, Emily C Walsh, Kuo-Kuang Wen, Melissa McKane, Jihui Ren, Jonathan Alexander, Peter A Rubenstein, Didier Y R Stainier
Publikováno v:
PLoS Biology, Vol 2, Iss 5, p E129 (2004)
Function of the heart begins long before its formation is complete. Analyses in mouse and zebrafish have shown that myocardial function is not required for early steps of organogenesis, such as formation of the heart tube or chamber specification. Ho
Externí odkaz:
https://doaj.org/article/d88074e9b89d42a8bf11df9ab3a10802
Autor:
Kristina W. Thiel, Xiangbing Meng, Xinhao Wang, Meng Wu, Haitao Liu, Jianling Bi, Megan E McDonald, Kimberly K. Leslie, Kuo-kuang Wen, Mary Li, Shujie Yang, Yujun Li, Yiyang Li, Yuping Zhang
Publikováno v:
Cancers; Volume 10; Issue 5; Pages: 149
Cancers
Cancers
Tumor suppressor p53 is responsible for enforcing cell cycle checkpoints at G1/S and G2/M in response to DNA damage, thereby allowing both normal and tumor cells to repair DNA before entering S and M. However, tumor cells with absent or mutated p53 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c441f4a27d0597f9d5c944454dc6ba2