β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling.

Autor: Mathew J; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Zhou B; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States., Haney RS; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Kunz KA; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States., Do Amaral LS; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Roy Chowdhury R; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States., Butler JH; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Li H; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Chakraborty AJ; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Tabassum A; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Bremers EK; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Merino EF; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Coyle R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 4HN, U.K., Lee MCS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K.; Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee DD1 4HN, U.K., Baud D; Medicines for Malaria Venture, Geneva 1215, Switzerland., Brand S; Medicines for Malaria Venture, Geneva 1215, Switzerland., Totrov M; Molsoft LLC, 11999 Sorrento Valley Road, San Diego, California 92121, United States., Cassera MB; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 E. Green Street, Athens, Georgia 30602, United States., Carlier PR; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.; Department of Pharmaceutical Sciences, University of Illinois Chicago, 833 S Wood Street, Chicago, Illinois 60612, United States.; Department of Chemistry, University of Illinois Chicago, 845 W Taylor Street, Chicago, Illinois 60607, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Nov 08; Vol. 10 (11), pp. 3951-3962. Date of Electronic Publication: 2024 Oct 28.

Malaria Box-Inspired Discovery of N -Aminoalkyl-β-carboline-3-carboxamides, a Novel Orally Active Class of Antimalarials.

Autor: Mathew J; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Ding S; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Kunz KA; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Stacy EE; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States., Butler JH; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 Green Street, Athens, Georgia 30602, United States., Haney RS; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 Green Street, Athens, Georgia 30602, United States., Merino EF; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 Green Street, Athens, Georgia 30602, United States., Butschek GJ; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 Green Street, Athens, Georgia 30602, United States., Rizopoulos Z; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Totrov M; Molsoft LLC, 11999 Sorrento Valley Road, San Diego, California 92121, United States., Cassera MB; Department of Biochemistry and Molecular Biology and Center for Tropical and Emerging Global Diseases, University of Georgia, 120 Green Street, Athens, Georgia 30602, United States., Carlier PR; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, 1040 Drillfield Drive, Blacksburg, Virginia 24061, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Feb 23; Vol. 13 (3), pp. 365-370. Date of Electronic Publication: 2022 Feb 23 (Print Publication: 2022).

Thermolysis of Geminal Diazides: Reagent-Free Synthesis of 3-Hydroxypyridines.

Autor: Erhardt H; Organic Chemistry, Bergische Universität Wuppertal , Gaußstraße 20, 42119 Wuppertal, Germany., Kunz KA; Organic Chemistry, Bergische Universität Wuppertal , Gaußstraße 20, 42119 Wuppertal, Germany., Kirsch SF; Organic Chemistry, Bergische Universität Wuppertal , Gaußstraße 20, 42119 Wuppertal, Germany.

Publikováno v: Organic letters [Org Lett] 2017 Jan 06; Vol. 19 (1), pp. 178-181. Date of Electronic Publication: 2016 Dec 16.