Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant.

Autor: Carmody PJ; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Roushar FJ; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Tedman A; The James Tarpo Junior and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907., Wang W; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233., Herwig M; Department of Chemistry, Vanderbilt University, Nashville, TN 37240., Kim M; Department of Chemistry, Vanderbilt University, Nashville, TN 37240.; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN 37240., McDonald EF; Department of Chemistry, Vanderbilt University, Nashville, TN 37240., Noguera K; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Wong-Roushar J; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Poirier JL; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Zelt NB; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Pockrass BT; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., McKee AG; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Kuntz CP; The James Tarpo Junior and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907., Raju SV; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN 37240.; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37240., Penn WD; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Schlebach JP; The James Tarpo Junior and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2414768121. Date of Electronic Publication: 2024 Oct 10.

Ribosomal Frameshifting Selectively Modulates the Assembly, Function, and Pharmacological Rescue of a Misfolded CFTR Variant.

Autor: Carmody P; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Roushar FJ; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Tedman A; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907., Wang W; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA 35233., Herwig M; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240., Kim M; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240.; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA 37240., McDonald EF; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240., Noguera K; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Wong-Roushar J; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Poirier JL; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Zelt NB; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Pockrass BT; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., McKee AG; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Kuntz CP; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907., Raju SV; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA 35233., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240.; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA 37240., Penn WD; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Schlebach JP; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 23. Date of Electronic Publication: 2024 Jul 23.

Structure-Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor.

Autor: Bosquez-Berger T; Gill Center for Biomolecular Science, Department of Psychological and Brain Sciences, Program in Neuroscience, Indiana University, Bloomington, Indiana 47405, United States., Gudorf JA; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Desmond JA; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., VanNieuwenhze MS; Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States., Straiker A; Gill Center for Biomolecular Science, Department of Psychological and Brain Sciences, Program in Neuroscience, Indiana University, Bloomington, Indiana 47405, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jul 27; Vol. 66 (14), pp. 9466-9494. Date of Electronic Publication: 2023 Jul 12.

Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal.

Autor: Roushar FJ; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., McKee AG; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Ortega JT; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Penn WD; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Woods H; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee, USA., Chamness LM; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Most V; Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany., Jastrzebska B; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, Indiana, USA. Electronic address: jschleba@indiana.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102266. Date of Electronic Publication: 2022 Jul 16.

Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning.

Autor: Carmody PJ; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Zimmer MH; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Harrington HR; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Duckworth KE; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Penn WD; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Mukhopadhyay S; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Miller TF; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Dec 16; Vol. 49 (22), pp. 12943-12954.