Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab)

Autor: Wendy N. Wiesend, Sean Carlin, Kuntal K. Sevak, Brooke McKnight, Dalya Abdel-Atti, Dakshnamurthy Selvakumar, Akhila N. W. Kuda-Wedagedara, Anson Ku, Jason S. Lewis, Nerissa Viola-Villegas

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Tumor resistance to treatment paved the way toward the development of single agent drugs that target multiple molecular signatures amplified within the malignancy. The discovered crosstalk between EGFR and HER3 as well as the role of HER3 in mediatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbef806cec51f3a1ce29ca0aa2e53e08
http://link.springer.com/article/10.1038/s41598-018-27454-6

89Zr-DFO-AMG102 Immuno-PET to Determine Local Hepatocyte Growth Factor Protein Levels in Tumors for Enhanced Patient Selection

Autor: Eric W. Price, Yelena Y. Janjigian, Kathryn E. Carnazza, Elisa de Stanchina, Kimberly J. Edwards, Kuntal K. Sevak, Jason S. Lewis, Sean Carlin, Jonathan M. Glaser, Andrew Cho

The hepatocyte growth factor (HGF) binding antibody rilotumumab (AMG102) was modified for use as a 89Zr-based immuno-PET imaging agent to noninvasively determine the local levels of HGF protein in tumors. Because recent clinical trials of HGF-targeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69af81bc9ab5382d43185bba5b3a6df6
https://europepmc.org/articles/PMC5577625/

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry

Autor: Kuntal K. Sevak, Thomas Reiner, Pat Zanzonico, Jason S. Lewis, Priya Mohindra, Ralph Weissleder, Brian M. Zeglis, Sean Carlin

Publikováno v: Journal of Nuclear Medicine. 54:1389-1396

The specificity of antibodies have made immunoconjugates promising vectors for the delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives necessitate the use of radioisotopes with long physical half-lives, a combinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19f742f6c17420f1708f1652e38ecd
https://doi.org/10.2967/jnumed.112.115840

Synthesis and evaluation of 18F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression

Autor: Nagavarakishore Pillarsetty, Vadim Divilov, Nicholas Ramos, Jason S. Lewis, Brian M. Zeglis, Pierre Daumar, Kuntal K. Sevak

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 86, pp.769-781. ⟨10.1016/j.ejmech.2014.09.019⟩

Type II topoisomerase (Topo-II) is an ATP-dependent enzyme that is essential in the transcription, replication, and chromosome segregation processes and, as such, represents an attractive target for cancer therapy. Numerous studies indicate that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4402b04154e212dd1b866b3169a1e2a
https://hal.archives-ouvertes.fr/hal-03121843

Noninvasive Imaging of PSMA in prostate tumors with (89)Zr-Labeled huJ591 engineered antibody fragments: the faster alternatives

Autor: Henry W. Evans, Sean Carlin, Michael G. Doran, Anna M. Wu, Jason S. Lewis, Derek W. Bartlett, Kuntal K. Sevak, Nerissa Viola-Villegas

Publikováno v: Molecular Pharmaceutics

Engineered antibody fragments offer faster delivery with retained tumor specificity and rapid clearance from nontumor tissues. Here, we demonstrate that positron emission tomography (PET) based detection of prostate specific membrane antigen (PSMA) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047ff061085e9bdfa62200923a8b7a5b
https://pubmed.ncbi.nlm.nih.gov/24779727