Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kunqi Chen"'
Autor:
Tingjun Li, Yiqin Huang, Shien Cui, Zhipeng Hong, Xinhai Zhang, Zhihao Li, Kunqi Chen, Debo Chen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Immunotherapy research focuses on reshaping the tumor microenvironment (TME) to enhance its antitumor immune responses, with an emphasis on understanding the impact of RNA methylation in triple-negative breast cancer (TNBC) TME regulation. T
Externí odkaz:
https://doaj.org/article/eccc2e258b364b35bf3914e60653b797
Autor:
Jiaming Huang, Xuan Wang, Rong Xia, Dongqing Yang, Jian Liu, Qi Lv, Xiaoxuan Yu, Jia Meng, Kunqi Chen, Bowen Song, Yue Wang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3175-3185 (2024)
5-formylcytidine (f5C) is a unique post-transcriptional RNA modification found in mRNA and tRNA at the wobble site, playing a crucial role in mitochondrial protein synthesis and potentially contributing to the regulation of translation. Recent studie
Externí odkaz:
https://doaj.org/article/19fbae14828d42c5a0c5a1bbcf13298b
Autor:
Rong Xia, Xiangyu Yin, Jiaming Huang, Kunqi Chen, Jiongming Ma, Zhen Wei, Jionglong Su, Neil Blake, Daniel J. Rigden, Jia Meng, Bowen Song
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102376- (2024)
Cancer is a complex and multifaceted group of diseases characterized by uncontrolled cell growth that leads to the formation of malignant tumors. Recent studies suggest that N6-methyladenosine (m6A) RNA methylation plays pivotal roles in cancer patho
Externí odkaz:
https://doaj.org/article/da176ee8742f429abfdbe1de4a69633b
Autor:
Xiaohuang Lin, Jian Zhang, Zekai Wu, Yuan Shi, Mengting Chen, Maodong Li, Hong Hu, Kun Tian, Xiaoqi Lv, Chutao Li, Yang Liu, Xinyue Gao, Qiaomei Yang, Kunqi Chen, An Zhu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Mesaconitine (MA), a diester-diterpenoid alkaloid extracted from the medicinal herb Aconitum carmichaelii, is commonly used to treat various diseases. Previous studies have indicated the potent toxicity of aconitum despite its pharmacolog
Externí odkaz:
https://doaj.org/article/e64112f8d9d44a47aa52a3ec80da6ee4
Autor:
Bowen Song, Daiyun Huang, Yuxin Zhang, Zhen Wei, Jionglong Su, João Pedro de Magalhães, Daniel J. Rigden, Jia Meng, Kunqi Chen
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 4, Pp 678-694 (2023)
As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs (lncRNAs), N6-methyladenosine (m6A) RNA methylation has been shown to participate in essential biological processes. Recent studies have revealed the distinct patterns
Externí odkaz:
https://doaj.org/article/64edc163a5604d168eefcf22d58a8d11
Autor:
Xiaoying Chen, Hong Hu, Xiaohuang Lin, Mengting Chen, Wenqiang Bao, Yajiao Wu, Chutao Li, Yadong Gao, Shaozhang Hou, Qiaomei Yang, Li Chen, Jian Zhang, Kunqi Chen, Qi Wang, An Zhu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115919- (2023)
Euphorbia factor L1 (EFL1) is a kind of lathyrane-type diterpenoid and is isolated from the medical herb Euphorbia lathyris L. (Euphorbiaceae); it has been reported with the toxicity that causes intestinal irritation, but the underlying mechanisms ar
Externí odkaz:
https://doaj.org/article/2c325352c7b041ba92df542c451ccb42
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-15 (2022)
Abstract Epigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In addition to apoptosis, Brd4 has also been shown to regulate s
Externí odkaz:
https://doaj.org/article/b7de9c263abe42018f1161cb8c55752c
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/b11b7914f16840bca83db92543952530
Autor:
Zitao Song, Daiyun Huang, Bowen Song, Kunqi Chen, Yiyou Song, Gang Liu, Jionglong Su, João Pedro de Magalhães, Daniel J. Rigden, Jia Meng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
RNA modifications appear to play a role in determining RNA structure and function. Here, the authors develop a deep learning model that predicts the location of 12 RNA modifications using primary sequence, and show that several modifications are asso
Externí odkaz:
https://doaj.org/article/2013910e98b9461eaf0247a35dedc43a
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 742-747 (2020)
As one of the widely occurring RNA modifications, 5-methyluridine (m5U) has recently been shown to play critical roles in various biological functions and disease pathogenesis, such as under stress response and during breast cancer development. Preci
Externí odkaz:
https://doaj.org/article/8a91362d98344a8ba1a94e98c999996c