Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kunpeng Qin"'
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114644- (2024)
Externí odkaz:
https://doaj.org/article/d46bb5188422452c9c2d0f0d15910c81
Publikováno v:
eLife, Vol 12 (2024)
Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, human GSDME is
Externí odkaz:
https://doaj.org/article/662be3aceaff424486d20c1c98611d32
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102708- (2023)
Summary: Pyroptosis is a type of regulated necrosis executed by gasdermin. Osmotic cell swelling and membrane perforation are the key features of pyroptosis. This protocol presents time-lapse imaging of morphological changes during pyroptosis using a
Externí odkaz:
https://doaj.org/article/bfeedb2de8394c10b037656edd566ceb
Autor:
Qing Tao, Di Yang, Kunpeng Qin, Lei Liu, Mengmeng Jin, Famin Zhang, Jinjin Zhu, Jie Wang, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Chu
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Background Alzheimer's disease presents an abnormal cognitive behavior. TgCtwh6 is one of the predominant T. gondii strains prevalent in China. Although T. gondii type II strain infection can cause host cognitive behavioral abnormalities, we
Externí odkaz:
https://doaj.org/article/b68daf67763f4bbcba411de12b00de28
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112414- (2023)
Summary: Gasdermin (GSDM) is a family of proteins that execute pyroptosis in vertebrate. In invertebrate, pyroptotic GSDM was documented only in coral. Recent studies identified abundant GSDM structural homologs in Mollusca, but their functions are u
Externí odkaz:
https://doaj.org/article/837ff5ccc30c48c08568a15ececf1e44
Autor:
Hao Tang, Kunpeng Qin, Anquan Wang, Shuang Li, Sheng Fang, Weilu Gao, Ming Lu, Wei Huang, Hui Zhang, Zongsheng Yin
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction. The pathological mechanisms are complex; in particular, inflammation, autophagy, and apoptosis are often involved. 3,3-Diindolylmethane (DIM
Externí odkaz:
https://doaj.org/article/81c407d347f74ae7b4a8aee70ddfd056
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Osteoarthritis (OA) is the most common chronic disease characterized by a loss of chondrocytes and the degeneration of cartilage. Inflammation plays an important role in the pathogenesis and progression of OA via the activation of the endoplasmic ret
Externí odkaz:
https://doaj.org/article/4109726c4eaf4e4dabeef9a9032c3470
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Gasdermin (GSDM) is a family of pore-forming proteins that induce pyroptosis. To date, the origin and evolution of GSDM in Metazoa remain elusive. Here, we found that GSDM emerged early in Placozoa but is absent in a large number of invertebrates. In
Externí odkaz:
https://doaj.org/article/0ab5f77700bd4aecb9db4784e32e2bf2
Autor:
Meilan Xue, Hui Liang, Zhitong Zhou, Ying Liu, Xinjia He, Zheng Zhang, Ting Sun, Jia Yang, Yimin Qin, Kunpeng Qin
Publikováno v:
Food & Nutrition Research, Vol 65, Iss 0, Pp 1-14 (2021)
Background: Alcoholic liver disease is caused as a result of chronic alcohol consumption. In this study, we used an alcoholic liver injury mouse model to investigate the effect of fucoidan on ethanol-induced liver injury and steatosis and the underly
Externí odkaz:
https://doaj.org/article/2537a4e9eab04d39b487fc2796532cf1
Publikováno v:
Phytotherapy Research. 35:6904-6917
Fucoidan is a marine-origin sulfated polysaccharide that has gained attention for its anticancer activities. However, the inhibitory effect of fucoidan on breast cancers by regulating autophagy and its mechanism are not clear, and the chemotherapeuti