Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kuno Wuersch"'
Autor:
Colin Chinn, Clemence Tessier, Matthew Spendiff, Ajay Lal, Marguerite Bracher, Elisabeth Rosner, Gregory Hollingworth, Paul Nicklin, Andrew James Culshaw, Matthew Thomas, Stephen Marshall, Benjamin R. Bellenie, Edward Charles Hall, Ian N. Bruce, Kuno Wuersch, Ameet Vijay Ambarkhane, Julie Coote, Gillian Wallis, James Neef, Eva Cullen, Sarah McDonald
Publikováno v:
Journal of Medicinal Chemistry. 64:12304-12321
Using a novel physiologically relevant in vitro human whole blood neutrophil shape change assay, an aminopyrazine series of selective PI3Kγ inhibitors was identified and prioritized for further optimization. Severe solubility limitations associated
Autor:
Arno Doelemeyer, Thierry Flandre, Vincent Romanet, Alessandro Piaia, Julie Boisclair, Esther Sutter, Kuno Wuersch, Gianluca Santarossa, Holger Hoefling, Tobias Sing, Chandrassegar Saravanan, Pierre Moulin, Oliver C. Turner, Imtiaz Hossain
Publikováno v:
Toxicologic pathology. 49(4)
We introduce HistoNet, a deep neural network trained on normal tissue. On 1690 slides with rat tissue samples from 6 preclinical toxicology studies, tissue regions were outlined and annotated by pathologists into 46 different tissue classes. From the
Autor:
Zuhal Dincer, Jagannatha Mysore, Frank J. Geoly, Maria Cristina De Vera Mudry, Cecilia Parrula, Kuno Wuersch
Publikováno v:
Toxicologic pathology. 48(8)
In nonrodent toxicity studies that are usually conducted in cynomolgus monkeys or beagle dogs, the added value of examining all tissues from all dose groups (current practice) versus all tissues in only control and high-dose groups and target tissues
Autor:
Tobias Sing, Arno Doelemeyer, Julie Boisclair, Santarossa G, Oliver C. Turner, Chandrassegar Saravanan, Esther Sutter, Imtiaz Hossain, Pierre Moulin, Alessandro Piaia, Holger Hoefling, Kuno Wuersch, Romanet, Thierry Flandre
Deep learning models have been applied on various tissues in order to recognize malignancies. However, these models focus on relatively narrow tissue context or well-defined pathologies. Here, instead of focusing on pathologies, we introduce models c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6cf3ee42cf4cb91979fcee0584ab45
Autor:
Alan P. Brown, Philip Drew, Philippe Marc, Brian Knight, Kuno Wuersch, Sean P. Troth, Joyce Zandee
Publikováno v:
Regulatory Toxicology and Pharmacology. 82:167-172
Histopathology data comprise a critical component of pharmaceutical toxicology studies and are typically presented as finding incidence counts and severity scores per organ, and tabulated on multiple pages which can be challenging for review and aggr
Autor:
Terrilyn A. Richardson, Chi-Hse Teng, Audrey Fischer, Marianne Schwald, William Kluwe, Joerg Andreas Mahl, Robin Alec Fairhurst, Luigi Manenti, Francois Pognan, Armin Wolf, Gerd A. Kullak-Ublick, Mathilde Lienard, Jacqueline Kinyamu-Akunda, Elizabeth Skuba, Salah-Dine Chibout, Andreas Weiss, Kuno Wuersch, Philippe Couttet, Heiko Schadt, Diana Graus Porta, Corinne Emotte
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 163(1)
The FGF19- fibroblast growth factor receptor (FGFR4)-βKlotho (KLB) pathway plays an important role in the regulation of bile acid (BA) homeostasis. Aberrant activation of this pathway has been described in the development and progression of a subset
Autor:
Sabine Guth-Gundel, Benjamin R. Freedman, Michael Schuleit, Andreas Kuttler, Bruno Tigani, Mara Fornaro, Michaela Kneissel, Alexander G. Stafford, Jianyu Li, Anne Basler, David J. Mooney, Arno Doelemeyer, Nathalie Accart, Kuno Wuersch, Eckhard Weber, Christine Halleux
Publikováno v:
Advanced healthcare materials. 7(9)
Hydrogels are under active development for controlled drug delivery, but their clinical translation has been limited by low drug loading capacity, deficiencies in mechanical toughness and storage stability, and poor control over the drug release that
Autor:
Christina Piskernik, Hans Peter Schwarz, Eva-Maria Muchitsch, Kuno Wuersch, Hanspeter Rottensteiner, Alexandra Schiviz, Barbara Dietrich, Werner Hoellriegl, Friedrich Scheiflinger
Publikováno v:
Blood. 119:6128-6135
Deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), a VWF-cleaving protease, is the key factor in the pathogenesis of thrombotic thrombocytopenic purpura (TTP), a life-threatening thrombotic mic
Autor:
Barbara Dietrich, Susan Kubik, Wilfried Auer, Kuno Wuersch, Birgit Reipert, Frank Horling, Martin Wolfsegger, Hartmut J. Ehrlich, Friedrich Scheiflinger, Hans Peter Schwarz, Eva-Maria Muchitsch
Publikováno v:
Blood. 116:4654-4654
Abstract 4654 Baxter has developed a rFIX product which is produced by a genetically engineered Chinese hamster ovary (CHO) cell line in a cell culture medium free from any animal or human proteins. The objective of this preclinical study-program was