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Metabolic activation of 3-aminodibenzofuran mediated by P450 enzymes and sulfotransferases

Autor: Yang Wang, Kunna Li, Ying Zou, Mengyue Zhou, Jing Li, Chutian Wu, Rong Tan, Yufen Liao, Weiwei Li, Jiang Zheng

Publikováno v: Toxicology Letters. 360:44-52

3-Aminodibenzofuran (3-ADBF) is a potent bladder carcinogen. This study aimed to identify reactive metabolites and the metabolic pathways of 3-ADBF. The in vitro and in vivo studies demonstrated that 3-ADBF was oxidized to the corresponding hydroxyla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa14480117e6348c39256874833696d
https://doi.org/10.1016/j.toxlet.2022.03.005

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2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene

Autor: Kunna Li, Ying Zou, Yang Wang, Mengyue Zhou, Jing Li, Rong Tan, Shiyu Zhang, Weiwei Li, Jiang Zheng

Publikováno v: Xenobiotica. 52:360-369

2-Methylnaphthalene (2-MN) is an environmental pollutant. Studies have shown that 2-MN is teratogenic, carcinogenic, and cytotoxic. However, the mechanisms of 2-MN induced toxicities remain unclear.This study aimed to characterise reactive metabolite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3943d467dbc0c93a23b75a62084d517b
https://doi.org/10.1080/00498254.2022.2079022

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Inverse modeling of Chinese NOx emissions using deep learning: Integrating in situ observations with a satellite-based chemical reanalysis

Autor: Tai-Long He, Dylan B. A. Jones, Kazuyuki Miyazaki, Kevin W. Bowman, Zhe Jiang, Xiaokang Chen, Rui Li, Yuxiang Zhang, Kunna Li

Nitrogen dioxide (NO2) column density measurements from satellites have been widely used in constraining emissions of nitrogen oxides (NOx = NO + NO2). However, the utility of these measurements is impacted by reduced observational coverage due to cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf600f6a73726b6bef3e7d36a588cda
https://acp.copernicus.org/preprints/acp-2022-251/

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Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole‐induced alteration in toxicokinetic properties

Autor: Kunna Li, Jiang Zheng, Jing Li, Xiaoqiong Lai, Mengyue Zhou, Weiwei Li, Yang Wang, Ying Zou

Publikováno v: Biomedical Chromatography. 36

Retrorsine (RTS) is a toxic retronecine-type pyrrolizidine alkaloid, which is widely distributed. The purpose of this study was to develop a high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for serum RTS determinatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac90b1c84276b7de78405a56beef36a
https://doi.org/10.1002/bmc.5270

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Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L

Autor: Rong, Tan, Zixia, Hu, Mengyue, Zhou, Ying, Liu, Yang, Wang, Ying, Zou, Kunna, Li, Shiyu, Zhang, Jie, Pan, Ying, Peng, Weiwei, Li, Jiang, Zheng

Publikováno v: Phytomedicine. 102:154174

Dioscorea bulbifera L. (DBL) is an herbal medicine used for the treatment of thyroid diseases and tumors in China. However, the hepatotoxicity of DBL limits its wide safe use. Diosbulbin B (DSB) is the most abundant diterpene lactone occurring in DBL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66dd393184de8f02d001ee175a9f35b7
https://doi.org/10.1016/j.phymed.2022.154174

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