Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kunli Qu"'
Autor:
Xiaoguang Pan, Kunli Qu, Hao Yuan, Xi Xiang, Christian Anthon, Liubov Pashkova, Xue Liang, Peng Han, Giulia I. Corsi, Fengping Xu, Ping Liu, Jiayan Zhong, Yan Zhou, Tao Ma, Hui Jiang, Junnian Liu, Jian Wang, Niels Jessen, Lars Bolund, Huanming Yang, Xun Xu, George M. Church, Jan Gorodkin, Lin Lin, Yonglun Luo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Thorough evaluation of CRISPR RNA-guided nucleases off-targets in cells is required for advancing gene therapies. Here the authors report SURRO-seq for the simultaneous investigation of thousands of off-target sites for therapeutic RNA-guided nucleas
Externí odkaz:
https://doaj.org/article/faf474f6db144a9c827ec4b0d699e6f7
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CRISPR/Cas9-mediated cleavage efficiency varies at different target locations. Here the authors explain this variation with binding free energy changes and show that overlapping Cas9 binding sites influence cleavage efficiency by enabling Cas9 slidin
Externí odkaz:
https://doaj.org/article/a7a165af1e074db9a6b4de1943d8d44e
Autor:
Tianyu Zheng, Jinrong Huang, Xi Xiang, Siyuan Li, Jiaying Yu, Kunli Qu, Zhe Xu, Peng Han, Zhanying Dong, Yang Liu, Fengping Xu, Huanming Yang, Marja Jäättelä, Yonglun Luo, Bin Liu
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
Abstract The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning. The promoters of CREB1-targeted genes responsive to cA
Externí odkaz:
https://doaj.org/article/f1ddfdb0b03b4de7b35f3ef3981e0ad5
Autor:
Xi Xiang, Xiaoying Zhao, Xiaoguang Pan, Zhanying Dong, Jiaying Yu, Siyuan Li, Xue Liang, Peng Han, Kunli Qu, Jonas Brorson Jensen, Jean Farup, Fei Wang, Trine Skov Petersen, Lars Bolund, Huajing Teng, Lin Lin, Yonglun Luo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 403-415 (2021)
CRISPR gene therapy is one promising approach for treatment of Duchenne muscular dystrophy (DMD), which is caused by a large spectrum of mutations in the dystrophin gene. To broaden CRISPR gene editing strategies for DMD treatment, we report the effi
Externí odkaz:
https://doaj.org/article/44c00caf65914edda601b5af7df244cb
Autor:
Xi Xiang, Giulia I. Corsi, Christian Anthon, Kunli Qu, Xiaoguang Pan, Xue Liang, Peng Han, Zhanying Dong, Lijun Liu, Jiayan Zhong, Tao Ma, Jinbao Wang, Xiuqing Zhang, Hui Jiang, Fengping Xu, Xin Liu, Xun Xu, Jian Wang, Huanming Yang, Lars Bolund, George M. Church, Lin Lin, Jan Gorodkin, Yonglun Luo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
High-quality gRNA activity data is needed for accurate on-target efficiency predictions. Here the authors generate activity data for over 10,000 gRNA and build a deep learning model CRISPRon for improved performance predictions.
Externí odkaz:
https://doaj.org/article/d2630a00271e4fa5a1f663c1d03d658b
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 870 (2023)
Recent progress in CRISPR gene editing tools has substantially increased the opportunities for curing devastating genetic diseases. Here we compare in-frame deletion by CRISPR-based non-homologous blunt end joining (NHBEJ), homology-directed repair (
Externí odkaz:
https://doaj.org/article/c10740cee87c4cd3bc27cb4636b9f628
Autor:
Wei Lv, Xiaoguang Pan, Peng Han, Ziyu Wang, Weijia Feng, Xue Xing, Qingqing Wang, Kunli Qu, Yuchen Zeng, Cailin Zhang, Zhe Xu, Yi Li, Tianyu Zheng, Ling Lin, Chengxun Liu, Xuemei Liu, Hanbo Li, Rasmus Amund Henriksen, Lars Bolund, Lin Lin, Xin Jin, Huanming Yang, Xiuqing Zhang, Tailang Yin, Birgitte Regenberg, Fan He, Yonglun Luo
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Background Extrachromosomal circular deoxyribonucleic acid (eccDNA) is evolving as a valuable biomarker, while little is known about its presence in urine. Methods Here, we report the discovery and analysis of urinary cell‐free eccDNAs (uc
Externí odkaz:
https://doaj.org/article/c6ab9a4e1e1c454e8d03a9d10080d3a9
Autor:
Ming Li, Jiali Gao, Yan Tang, Meishuo Liu, Sijin Wu, Kunli Qu, Xiangyu Long, Huajun Li, Min Liu, Yinhui Liu, Jieli Yuan, Lei Mao, Yu Liu, Xiliang Zheng, Erkang Wang, Jin Wang, Yongliang Yang
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2018)
Sulforaphene (LFS-01) is a natural compound derived from traditional herbal medicine. Here, we show that oral administration of LFS-01 is able to dramatically alter the skewed gut microbiota and reverse colitis in model mice associated with an increa
Externí odkaz:
https://doaj.org/article/500a0c38c4f147e69ef5d52784feabed
Autor:
Jiaying Huang, Qiupeng Lin, Hongyuan Fei, Zixin He, Hu Xu, Yunjia Li, Kunli Qu, Peng Han, Qiang Gao, Boshu Li, Guanwen Liu, Lixiao Zhang, Jiacheng Hu, Rui Zhang, Erwei Zuo, Yonglun Luo, Yidong Ran, Jin-Long Qiu, Kevin Tianmeng Zhao, Caixia Gao
SummaryThe elucidation of protein function and its exploitation in bioengineering have greatly contributed to the development of the life sciences. Existing protein mining efforts generally rely on amino acid sequences rather than protein structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce29881701a8d77ee83a21dd1c07033
https://doi.org/10.1101/2023.05.21.541555
https://doi.org/10.1101/2023.05.21.541555
Autor:
Zhe Xu, Xi Xiang, Yang Liu, Bin Liu, Peng Han, Huanming Yang, Fengping Xu, Zhanying Dong, Jinrong Huang, Marja Jäättelä, Siyuan Li, Tianyu Zheng, Yonglun Luo, Jiaying Yu, Kunli Qu
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-16 (2021)
Zheng, T, Huang, J, Xiang, X, Li, S, Yu, J, Qu, K, Xu, Z, Han, P, Dong, Z, Liu, Y, Xu, F, Yang, H, Jäättelä, M, Luo, Y & Liu, B 2021, ' Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes ', Cancer Cell International, vol. 21, 530 . https://doi.org/10.1186/s12935-021-02224-z
Zheng, T, Huang, J, Xiang, X, Li, S, Yu, J, Qu, K, Xu, Z, Han, P, Dong, Z, Liu, Y, Xu, F, Yang, H, Jäättelä, M, Luo, Y & Liu, B 2021, ' Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes ', Cancer Cell International, vol. 21, no. 1, 530 . https://doi.org/10.1186/s12935-021-02224-z
Cancer Cell International
Zheng, T, Huang, J, Xiang, X, Li, S, Yu, J, Qu, K, Xu, Z, Han, P, Dong, Z, Liu, Y, Xu, F, Yang, H, Jäättelä, M, Luo, Y & Liu, B 2021, ' Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes ', Cancer Cell International, vol. 21, 530 . https://doi.org/10.1186/s12935-021-02224-z
Zheng, T, Huang, J, Xiang, X, Li, S, Yu, J, Qu, K, Xu, Z, Han, P, Dong, Z, Liu, Y, Xu, F, Yang, H, Jäättelä, M, Luo, Y & Liu, B 2021, ' Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes ', Cancer Cell International, vol. 21, no. 1, 530 . https://doi.org/10.1186/s12935-021-02224-z
Cancer Cell International
The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning. The promoters of CREB1-targeted genes responsive to cAMP have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631faa0454b2639ef96d4135cb09209d
https://doaj.org/article/f1ddfdb0b03b4de7b35f3ef3981e0ad5
https://doaj.org/article/f1ddfdb0b03b4de7b35f3ef3981e0ad5