Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kunjie Fan"'
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background The study of codon usage bias is important for understanding gene expression, evolution and gene design, providing critical insights into the molecular processes that govern the function and regulation of genes. Codon Usage Bias (
Externí odkaz:
https://doaj.org/article/9db4f6e5b30745abaf930c20eefc0142
Publikováno v:
Journal of Biomedical Semantics, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Drug-drug interaction (DDI) information retrieval (IR) is an important natural language process (NLP) task from the PubMed literature. For the first time, active learning (AL) is studied in DDI IR analysis. DDI IR analysis from Pu
Externí odkaz:
https://doaj.org/article/189d0ce3178c4a2d85c8f2c51d63d498
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Synthetic lethal (SL) genetic interactions have been regarded as a promising focus for investigating potential targeted therapeutics to tackle cancer. However, the costly investment of time and labor associated with wet-lab experimental screenings to
Externí odkaz:
https://doaj.org/article/555522724c9c4f8eb54c7303c3ce25b9
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Synthetic lethality (SL) refers to a genetic interaction in which the simultaneous perturbation of two genes leads to cell or organism death, whereas viability is maintained when only one of the pair is altered. The experimental exploration of these
Externí odkaz:
https://doaj.org/article/3cf16966a89b4a2091904db6bd601dca
Autor:
Shan Tang, Xue Wu, Jinghui Liu, Qiongsi Zhang, Xinyi Wang, Shuai Shao, Birkan Gokbag, Kunjie Fan, Xiaoqi Liu, Fuhai Li, Lijun Cheng, Lang Li
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101556- (2022)
Summary: Combinatorial CRISPR screening is useful for investigating synthetic lethality (SL) gene pairs. Here, we detail the steps for dual-gRNA library construction, with the introduction of two backbones, LentiGuide_DKO and LentiCRISPR_DKO. We desc
Externí odkaz:
https://doaj.org/article/b781ba81c6fb42079b2ddbbe820bbc17
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-16 (2020)
Abstract Background Protein-protein interactions (PPIs) are central to many biological processes. Considering that the experimental methods for identifying PPIs are time-consuming and expensive, it is important to develop automated computational meth
Externí odkaz:
https://doaj.org/article/219b1c6705b24be99c04b3b19f4af09a
Autor:
Kunjie Fan, Yan Zhang
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Pseudogenes are indicating more and more functional potentials recently, though historically were regarded as relics of evolution. Computational methods for predicting pseudogene functions on Gene Ontology is important for directing experimental disc
Externí odkaz:
https://doaj.org/article/d90ec95bf39b4163b2e6d03ca64fa688
Autor:
Jin Li, Yang Huo, Xue Wu, Enze Liu, Zhi Zeng, Zhen Tian, Kunjie Fan, Daniel Stover, Lijun Cheng, Lang Li
Publikováno v:
Biology, Vol 9, Iss 9, p 278 (2020)
In the prediction of the synergy of drug combinations, systems pharmacology models expand the scope of experiment screening and overcome the limitations of current computational models posed by their lack of mechanical interpretation and integration
Externí odkaz:
https://doaj.org/article/5735c7087c664af097e7f6ec83057eac
Publikováno v:
Magazine of Concrete Research. 74:1176-1187
Accurate modelling of transient creep strain (TRC) is crucial for reliable fire performance assessments of concrete structures, since it is the largest strain component for structural concrete subjected to thermal exposure. Nonetheless, the mechanism
Publikováno v:
Journal of Biomedical Semantics. 14
Background Drug-drug interaction (DDI) information retrieval (IR) is an important natural language process (NLP) task from the PubMed literature. For the first time, active learning (AL) is studied in DDI IR analysis. DDI IR analysis from PubMed abst