Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kuniya Sakurai"'
Autor:
Ryohei Yokoyama, Tomohisa Hatta, Ryusuke Nakagawa, Hayakawa Nobuhiko, Masataka Shoji, Makoto Shiozaki, Manami Shuto, Yoichiro Shima, Kanna Kuribayashi, Hiroyuki Eda, Misato Noguchi, Yukie Seki, Manabu Suzuki, Agung Eviryanti, Shun-ichiro Iemura, Ayatoshi Andou, Hikaru Nishio, Sen Takeshita, Takashi Yamamoto, Masatsugu Noguchi, Kuniya Sakurai, Tohru Natsume, Shunsuke Kageyama, Itsuya Tanabe
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3021-3029
Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, and multiple sclerosis. We describe the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c53b04d20fe65be97c1dad86158452b
https://doi.org/10.1016/j.bmc.2014.03.036
https://doi.org/10.1016/j.bmc.2014.03.036
Autor:
Seiji Oono, Kazumi Tashiro, Mitsuo Takahashi, Seinosuke Iwata, Yumiko Fukuda, Koichi Fujita, Masahiro Yamanashi, Masayuki Sugiki, Kazuyuki Sagi, Masataka Shoji, Akiko Okajima, Kuniya Sakurai, Shunji Takehana, Takashi Kayahara
Publikováno v:
Bioorganicmedicinal chemistry. 13(5)
An inhibitor of the complex of factor VIIa and tissue factor (fVIIa/TF), 2-substituted-4-amidinophenylpyruvic acid 1a, was structurally modified with the aim of increasing its potency and selectivity. The lead compound 1a was originally found in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4429f1820a9a75523b0e5234fa96aff
https://pubmed.ncbi.nlm.nih.gov/15698764
https://pubmed.ncbi.nlm.nih.gov/15698764
Autor:
Yoichiro Shima, Seinosuke Iwata, Shingo Makino, Masataka Shoji, Noriyasu Kataoka, Mitsuo Takahashi, Tadakiyo Nakagawa, Hiroshi Yamamoto, Suzuki Nobuyasu, Seiji Oono, Shunji Takehana, Kazumi Tashiro, Takashi Kayahara, Takashi Tsuji, Ryota Yoshimoto, Kazuyuki Sagi, Masahiro Yamanashi, Kohki Ishikawa, Yumiko Fukuda, Masaru Takayanagi, Kaoru Takenaka, Sayaka Shima, Kuniya Sakurai
Publikováno v:
Journal of medicinal chemistry. 46(10)
An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid substituents were incorporated into the P1 benzamidine moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767eb5e6a06e41647edd2dc14f8255b0
https://pubmed.ncbi.nlm.nih.gov/12723948
https://pubmed.ncbi.nlm.nih.gov/12723948
Publikováno v:
Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
Endothelin (ET) is a 21-amino acid peptide, and its receptor belongs to a family of Gprotein-coupled receptor. ET antagonist is expected to be a therapeutic agent for disease including myocardinal infarction, hypertension and restenosis. In an attemp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5b4fa63ba864f1e0771b6b8b9198139
https://doi.org/10.1007/978-1-4615-4141-7_103
https://doi.org/10.1007/978-1-4615-4141-7_103
Autor:
Manami Shuto, Takashi Yamamoto, Masatsugu Noguchi, Kuniya Sakurai, Shoji Masataka, Eviryanti Agung, Hiroyuki Eda, Yoichiro Shima, Ryusuke Nakagawa, Ryohei Yokoyama, Yukie Seki, Misato Noguchi, Hikaru Nishio, Ayatoshi Andou, Itsuya Tanabe, Hayakawa Nobuhiko, Sen Takeshita, Shunsuke Kageyama, Makoto Shiozaki
Publikováno v:
Gastroenterology. 142:S-864
A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (Pikfyve) Inhibitor Ameliorates Mouse Colitis by Inhibition of IL-12 and IL-23 Production From Macrophages Ayatoshi Andou, Takashi Yamamoto, Eviryanti Agung, Yukie Seki, Hikaru Nishio, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a211e5b155f94110a8e76126510ecc10
https://doi.org/10.1016/s0016-5085(12)63351-4
https://doi.org/10.1016/s0016-5085(12)63351-4
Publikováno v:
Tetrahedron Letters. 26:1333-1336
The title compound has been synthesized in enantiomerically pure form using diethyl L-tartrate as a chiral template.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c26344bb771ab254fb1f47f24ea693
https://doi.org/10.1016/s0040-4039(00)94886-x
https://doi.org/10.1016/s0040-4039(00)94886-x
Publikováno v:
Tetrahedron Letters. 27:4485-4488
Four 2,6-dideoxyhexoses; D-(+)-digitoxose, D-(+)-cymarose, D-(+)- olivose and D-(−)-oleandrose have been synthesized stereo- and enantio- selectively starting with (+)-(2R,3S)-1,2-epoxypent-4-en-3-ol prepared by asymmetric epoxidation of divinylcar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6ee219bef16436c84eb1c4268a2e4e2
https://doi.org/10.1016/s0040-4039(00)84985-0
https://doi.org/10.1016/s0040-4039(00)84985-0
Publikováno v:
Tetrahedron Letters. 26:6485-6488
A microbial metabolise (+)-citreoviral has been synthesized enantio-and stereo-selectively using newly developed asymmetric hydroxylation of tiglate esters for the construction of the key chiral building block.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9261d34a4677127d3a71aeaff656138f
https://doi.org/10.1016/s0040-4039(00)99033-6
https://doi.org/10.1016/s0040-4039(00)99033-6
Publikováno v:
Chemischer Informationsdienst. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69f7f6a02a8a3539671ab138f774da52
https://doi.org/10.1002/chin.198641200
https://doi.org/10.1002/chin.198641200
Publikováno v:
HETEROCYCLES. 24:249
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c8ce02d67147598d705aba7bbf62e67
https://doi.org/10.3987/r-1986-01-0249
https://doi.org/10.3987/r-1986-01-0249