Development of a Triazinyluronium-Based Dehydrative Condensing Reagent with No Heteroatomic Bonds.

Autor: Mizushima G; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Fujita H; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Kunishima M; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo 650-8586, Japan.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2024 Dec 20; Vol. 89 (24), pp. 18660-18664. Date of Electronic Publication: 2024 Dec 03.

Bicyclic-Ammonium-Incorporated Ylidic Nitrogen Groups for Strong π-Electron Donation in Push-Pull Benzene π-Conjugated Systems.

Autor: Fujita H; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Arai T; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Kuchiki N; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan., Kunishima M; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 minatojima, Chuo-ku, Kobe, Hyogo 650-8586, Japan.

Publikováno v: Organic letters [Org Lett] 2024 Sep 06; Vol. 26 (35), pp. 7313-7317. Date of Electronic Publication: 2024 Aug 26.

Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity.

Autor: Mizutani A; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan., Kobayashi M; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan., Nishi K; Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan., Fujita KI; Division of Cancer Genome and Pharmacotherapy, Department of Clinical Pharmacy, Showa University School of Pharmacy, Tokyo, Japan., Takahashi K; Department of Radiologic Technology, National Cancer Center Hospital East, Kashiwa, Japan., Muranaka Y; Department of Radiological Technology, Faculty of Health Science, Juntendo University, Tokyo, Japan., Sato K; Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Kitamura M; Faculty of Pharmaceutical Sciences, Matsuyama University, Matsuyama, Japan., Suzuki C; Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan., Nishii R; Department of Integrated Health Sciences, Graduate School of Medicine, Nagoya University, Nagoya, Japan., Shikano N; Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan., Magata Y; Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan., Ishida Y; Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan., Kunishima M; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan., Fukuchi K; Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan., Kawai K; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.; Biomedical Imaging Research Center, University of Fukui, Fukui, Japan.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Jun 19; Vol. 15, pp. 1397288. Date of Electronic Publication: 2024 Jun 19 (Print Publication: 2024).

Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers.

Autor: Fujita H; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. Electronic address: hfujita@staff.kanazawa-u.ac.jp., Arai S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan., Arakawa H; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Hamamoto K; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Kato T; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Arai T; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Nitta N; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Hotta K; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Hosokawa N; Department of Rheumatology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan., Ohbayashi T; Department of Rheumatology, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan., Takahashi C; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan., Inokuma Y; Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo, Hokkaido, 060-8628 Japan; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido, 001-0021 Japan., Tamai I; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Yano S; Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan., Kunishima M; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe, Hyogo 650-8586, Japan. Electronic address: kunisima@pharm.kobegakuin.ac.jp., Watanabe Y; Innovative Clinical Research Center, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan. Electronic address: yoshi.watanabe@staff.kanazawa-u.ac.jp.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Mar 15; Vol. 102, pp. 117674. Date of Electronic Publication: 2024 Mar 02.

Epitope-Based Specific Antibody Modifications.

Autor: Horie S; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Mishiro K; Institute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Nishino M; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Domae I; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Wakasugi M; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Matsunaga T; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan., Kunishima M; Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586, Japan.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2023 Nov 15; Vol. 34 (11), pp. 2022-2033. Date of Electronic Publication: 2023 Oct 20.