Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kunishige Onuma"'
Autor:
Tomoyuki Suezawa, Naoko Sasaki, Yuichi Yukawa, Nazgul Assan, Yuta Uetake, Kunishige Onuma, Rino Kamada, Daisuke Tomioka, Hidehiro Sakurai, Ryohei Katayama, Masahiro Inoue, Michiya Matsusaki
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Collagen is the most abundant protein in the human body and one of the main components of stromal tissues in tumors which have a high elastic modulus of over 50 kPa. Although collagen has been widely used as a cell culture scaffold for cance
Externí odkaz:
https://doaj.org/article/0dab417cad3f447aaf00e41ec9b38753
Autor:
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobumasa Takasugi, Kunishige Onuma, Mitsuhiko Osaki, Futoshi Okada, Taichi Ukegawa, Yasuo Takeuchi, Norihisa Yasui, Atsuko Yamashita, Hiroyuki Marusawa, Yosuke Matsushita, Toyomasa Katagiri, Takahiro Shibata, Koji Uchida, Sheng-Yong Niu, Nhi B. Lang, Tomohiro Nakamura, Kam Y. J. Zhang, Stuart A. Lipton, Takashi Uehara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic co
Externí odkaz:
https://doaj.org/article/2948479591604774a634757fd4634fae
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102395- (2023)
Summary: Patient-derived tumor organoids are three-dimensionally cultured cancer cells that enable a suitable platform for studying heterogeneity and plasticity of cancer. We present a protocol for tracking the growth fate of single cells and isolati
Externí odkaz:
https://doaj.org/article/34d7c884333045f9a11d1653dd85c2de
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Heterogeneous nature is a pivotal aspect of cancer, rendering treatment problematic and frequently resulting in recurrence. Therefore, advanced techniques for identifying subpopulations of a tumour in an intact state are essential to develop novel sc
Externí odkaz:
https://doaj.org/article/d286aac2c91644aea7ce868ab33afa14
Autor:
Roberto Coppo, Jumpei Kondo, Keita Iida, Mariko Okada, Kunishige Onuma, Yoshihisa Tanaka, Mayumi Kamada, Masayuki Ohue, Kenji Kawada, Kazutaka Obama, Masahiro Inoue
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105962- (2023)
Summary: Dynamic changes in cell properties lead to intratumor heterogeneity; however, the mechanisms of nongenetic cellular plasticity remain elusive. When the fate of each cell from colorectal cancer organoids was tracked through a clonogenic growt
Externí odkaz:
https://doaj.org/article/420f2737e0a044ecac30f47fd7df08ca
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-8 (2018)
Abstract Background Experimental and controlled human exposure studies have demonstrated additive effects of ambient particulate matter and ozone on health. A few epidemiological studies have suggested that ambient particulate matter components are i
Externí odkaz:
https://doaj.org/article/ab3037f64f6b4e3a9138d420603b3bcb
Autor:
Kunishige Onuma, Yusuke Kanda, Saori Suzuki Ikeda, Ryuta Sakaki, Takuya Nonomura, Masanobu Kobayashi, Mitsuhiko Osaki, Masataka Shikanai, Hiroshi Kobayashi, Futoshi Okada
Publikováno v:
Nutrients, Vol 7, Iss 12, Pp 10237-10250 (2015)
We have established an inflammation-related carcinogenesis model in mouse, in which regressive QR-32 cells subcutaneously co-implanted with a foreign body—gelatin sponge—convert themselves into lethal tumors due to massive infiltration of inflamm
Externí odkaz:
https://doaj.org/article/d005555e2f6349b98e6ace00879a23a7
Autor:
Mayuko Kawata, Jumpei Kondo, Kunishige Onuma, Yu Ito, Takeshi Yokoi, Junzo Hamanishi, Masaki Mandai, Tadashi Kimura, Masahiro Inoue
Publikováno v:
Cancer Science. 113(10):3437-3448
Peritoneal dissemination is a predominant pattern of metastasis in patients with advanced ovarian cancer. Despite recent progress in the management strategy, peritoneal dissemination remains a determinant of poor ovarian cancer prognosis. Using vario
Autor:
Kunishige Onuma, Masahiro Inoue
Publikováno v:
Cancer Science. 113:3657-3663
Apico-basal polarity is a fundamental property of the epithelium that functions as a barrier, holds cells together, and determines the directions of absorption and secretion. Apico-basal polarity is regulated by extracellular matrix-integrin binding
Autor:
Katsuhiro Tomofuji, Jumpei Kondo, Kunishige Onuma, Roberto Coppo, Hiroshi Horie, Koki Oyama, Eiji Miyoshi, Ken Fukumitsu, Takamichi Ishii, Etsuro Hatano, Masahiro Inoue
Publikováno v:
Hepatology Communications. 7