Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Kunisato Kuroi"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Copper-zinc superoxide dismutase (SOD1) has been proposed as one of the causative proteins of amyotrophic lateral sclerosis (ALS). The accumulation of non-native conformers, oligomers, and aggregates of SOD1 in motor neurons is considered re
Externí odkaz:
https://doaj.org/article/39428704bf864c928428fc744534b263
Autor:
Kohei Yokosawa, Shinji Kajimoto, Daiki Shibata, Kunisato Kuroi, Tomohiro Konno, Takakazu Nakabayashi
Publikováno v:
The Journal of Physical Chemistry Letters. 13:5692-5697
Liquid-liquid phase separation (LLPS) is an important phenomenon in biology, and it is desirable to develop quantitative methods to analyze protein droplets generated by LLPS. This study quantified the change in protein concentration in a droplet in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d0336bf1cc4e8f5c9b7b191c9f2feb
https://doi.org/10.1021/acs.jpclett.2c00962
https://doi.org/10.1021/acs.jpclett.2c00962
Publikováno v:
Molecules, Vol 25, Iss 16, p 3600 (2020)
Cu, Zn superoxide dismutase (SOD1) is a representative antioxidant enzyme that catalyzes dismutation of reactive oxygen species in cells. However, (E,E)-SOD1 mutants in which both copper and zinc ions were deleted exhibit pro-oxidant activity, contra
Externí odkaz:
https://doaj.org/article/3c1822e2ada74d638b523ddadd58c56b
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1864:148980
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a788d8fca2e7f1b5530dce450e801ee0
https://doi.org/10.1016/j.bbabio.2023.148980
https://doi.org/10.1016/j.bbabio.2023.148980
Autor:
Shinji Kajimoto, Takakazu Nakabayashi, Daiki Shibata, Kunisato Kuroi, Kazuki Murakami, Fumihiko Fujii
Publikováno v:
Chemical Science
Liquid–liquid phase separation (LLPS) plays an important role in a variety of biological processes and is also associated with protein aggregation in neurodegenerative diseases. Quantification of LLPS is necessary to elucidate the mechanism of LLPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7913dbae3651f81f487e575d95dd134
https://doi.org/10.1039/d0sc06095j
https://doi.org/10.1039/d0sc06095j
Autor:
Hirotsugu Hiramatsu, Kunisato Kuroi, Mutsuki Ueki, Takakazu Nakabayashi, Mana Kamijo, Yusuke Niwa
Publikováno v:
Physical Chemistry Chemical Physics. 22:1137-1144
Disulfide bonds play a fundamental role in controlling the tertiary structure of proteins; the formation or cleavage of some disulfide bonds can switch the structures and/or functions of proteins. Human galectin-1 (hGal-1), which is a lectin protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a5fefe54cc247dd209a21c5aa4ecbc
https://doi.org/10.1039/c9cp04881b
https://doi.org/10.1039/c9cp04881b
Publikováno v:
Biochemical and Biophysical Research Communications. 515:228-233
Cholesterol plays a number of roles in cell membranes, and dehydroergosterol (DHE) is a fluorescent derivative of cholesterol, which is used to investigate the association structure of cholesterol. Although the fluorescent property of DHE depends on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdf9a451f8a0abd0401069f21366150
https://doi.org/10.1016/j.bbrc.2019.05.109
https://doi.org/10.1016/j.bbrc.2019.05.109
Publikováno v:
Molecules, Vol 25, Iss 3600, p 3600 (2020)
Molecules
Volume 25
Issue 16
Molecules
Volume 25
Issue 16
Cu, Zn superoxide dismutase (SOD1) is a representative antioxidant enzyme that catalyzes dismutation of reactive oxygen species in cells. However, (E,E)-SOD1 mutants in which both copper and zinc ions were deleted exhibit pro-oxidant activity, contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa7a167953dd23670916774a0883fde
https://www.mdpi.com/1420-3049/25/16/3600
https://www.mdpi.com/1420-3049/25/16/3600
Publikováno v:
The journal of physical chemistry. B. 124(11)
The denatured Cu, Zn superoxide dismutase (SOD1) has the pro-oxidant activity that is suggested to be related with the pathogenesis of amyotrophic lateral sclerosis (ALS). We showed from the changes in the coordinated metal ions that the Cu ion in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f6c604bd83ab45d9c9026cab267d13
https://pubmed.ncbi.nlm.nih.gov/32101437
https://pubmed.ncbi.nlm.nih.gov/32101437
Publikováno v:
Biochimica et biophysica acta. General subjects. 1864(2)
Background Mutants of Cu,Zn-superoxide dismutase (SOD1) exhibit cytotoxicity such as aggregation and pro-oxidation after denaturation, which is thought to be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). In the present study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e21389fd86ab0553b0d3f915c5bd044
https://pubmed.ncbi.nlm.nih.gov/31348988
https://pubmed.ncbi.nlm.nih.gov/31348988