Výsledky vyhledávání - "Kuniomi Tachibana"

Effects of Immunization with CCR5-Based Cycloimmunogen on Simian/HIVSF162P3 Challenge

Autor: Takaaki Iiboshi, Kuniomi Tachibana, Masashi Kusaba, Nobutoki Takamune, Shibata Hideaki, Shozo Shoji, Mamoru Umeda, Shogo Misumi, Tadashi Nakasone, Masafumi Endo, Daisuke Nakayama, Ryouzaburo Mukai

Publikováno v: The Journal of Immunology. 176:463-471

A synthetic cycloimmunogen targeting the HIV-1 coreceptor CCR5 was evaluated for its capacity to induce CCR5-specific Abs with anti-HIV-1 activity in cynomolgus macaques. The cyclic closed-chain dodecapeptide (cDDR5) mimicking the conformation-specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7fb9c680f76b3dbc2e2d82295c2fd2
https://doi.org/10.4049/jimmunol.176.1.463

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Suppression of multiclade R5 and X4 human immunodeficiency virus type-1 infections by a coreceptor-based anti-HIV strategy

Autor: Shogo Misumi, Kuniomi Tachibana, Nobutoki Takamune, Mamoru Umeda, Daisuke Nakayama, Ryouzaburo Mukai, Shozo Shoji, Shibata Hideaki

Publikováno v: Journal of biochemistry. 138(5)

A cyclic chimeric dodecapeptide (cCD) mimicking the conformation-specific domains of CCR5 and CXCR4 was prepared in which Gly-Asp links the amino and carboxyl termini of two combined pentapeptides (S169-G173 of CCR5; E179-R183 of CXCR4) derived from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62197ff6fdc47ff3244749d3e61c2199
https://pubmed.ncbi.nlm.nih.gov/16272569

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N3-phenacyluridine as a new type of antinociceptive compound in mice

Autor: Toshiyuki, Kimura, Tomomi, Shimizu, Tatsuya, Funahashi, Mayumi, Nagakura, Kazuhito, Watanabe, Kuniomi, Tachibana, Shigemi, Kondo, Ing Kang, Ho, Ikuo, Yamamoto

Publikováno v: Research communications in molecular pathology and pharmacology.

The antinociceptive activity of N3-phenacyluridine, a novel hypnotic, was examined with tail pinch, hot plate and acetic acid-induced abdominal constriction methods by intracerebroventricular (i.c.v.) injection to mice. In the first method, N3-phenac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f061a95be353c34ae1b8ab2e60172fe
https://pubmed.ncbi.nlm.nih.gov/15686107

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A novel cyclic peptide immunization strategy for preventing HIV-1/AIDS infection and progression

Autor: Shogo Misumi, Tetsuro Honda, Kuniomi Tachibana, Masafumi Endo, Ryouzaburou Mukai, Mamoru Umeda, Nobutoki Takamune, Shozo Shoji

Publikováno v: The Journal of biological chemistry. 278(34)

A novel synthetic peptide immunogen targeting the human immunodeficiency virus type-1 (HIV-1) coreceptor CXCR4 was evaluated for its capacity to induce CXCR4-specific antibodies with anti-HIV-1 activity in BALB/c mice and cynomolgus monkeys. A cyclic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19c906ead53eff4bc6b23d4d4c766c4
https://pubmed.ncbi.nlm.nih.gov/12771150

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Evidence as a HIV-1 self-defense vaccine of cyclic chimeric dodecapeptide warped from undecapeptidyl arch of extracellular loop 2 in both CCR5 and CXCR4

Autor: Shinichiro Hayashi, Shogo Misumi, Masafumi Endo, Yasuhide Ido, Mamoru Umeda, Ryouzaburou Mukai, Shozo Shoji, Nobutoki Takamune, Kuniomi Tachibana

Publikováno v: Biochemical and biophysical research communications. 285(5)

Novel conformation-specific antibodies were raised against a cyclic chimeric dodecapeptidyl multiple antigen peptide (cCD-MAP) constructed with a spacer-armed Gly-Asp dipeptide and two pentapeptides (S(169)-Q(170)-K(171)-E(172)-G(173) of CCR5 and E(1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf08b9b01537caf46287710758535d0
https://pubmed.ncbi.nlm.nih.gov/11478800

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An allosteric drug, o,o'-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 Tat and NF-kappa B

Autor: Kazunobu Yamataka, Shozo Shoji, Kuniomi Tachibana, Akihiko Uda, Ryozaburo Mukai, Akihito Ogata, Shogo Misumi, Kazunobu Harano, Kazuchika Furuishi, Shuzo Matsushita

Publikováno v: Biochemical and biophysical research communications. 249(3)

The efficacy of o,o'-bismyristoyl thiamine disulfide (BMT) was examined in detail against HIV-1 laboratory isolates (HTLV-IIIB, JRFL, and MN), primary isolates (KMT and KMO), and simian immunodeficiency virus (SIVmac251) in vitro. BMT inhibited the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff89becc692b40f66b0a6dd378c51cbf
https://pubmed.ncbi.nlm.nih.gov/9731208

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