Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Kunio Ishii"'
Autor:
Asami Mori, Toshiaki Takei, Namiko Suzuki, Kenji Sakamoto, Masahiko Morita, Satoshi Nakagawa, Tsutomu Nakahara, Kunio Ishii
Publikováno v:
Heliyon, Vol 7, Iss 3, Pp e06532- (2021)
In our previous study, we found that the vasodilation of retinal arterioles induced by acetylcholine and BMS-191011, a large-conductance Ca2+-activated K+ (BKCa) channel opener, were diminished in diabetic rats. Currently, few agents ameliorate the i
Externí odkaz:
https://doaj.org/article/feab66514c9c46fb804c9e454012e9c8
Autor:
Naoto Iizuka, Akane Morita, Chihiro Kawano, Asami Mori, Kenji Sakamoto, Masakazu Kuroyama, Kunio Ishii, Tsutomu Nakahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 3, Pp 203-208 (2018)
Pathological retinal angiogenesis contributes to the pathogenesis of several ocular diseases. Valproic acid, a widely used antiepileptic drug, exerts anti-angiogenic effects by inhibiting histone deacetylase (HDAC). Herein, we investigated the effect
Externí odkaz:
https://doaj.org/article/c70d2ab428fb47b9ad5538a8a661646f
Autor:
Yuki Kurauchi, Koichi Mokudai, Masahiko Morita, Ayako Kamimura, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
Publikováno v:
Journal of Functional Foods, Vol 38, Iss , Pp 540-544 (2017)
We have previously reported that intravenous injection of l-citrulline, an α-amino acid isolated from watermelon juice, prevented the decrease in cerebral blood flow (CBF) during cortical spreading depression (CSD) in rats, a widely accepted animal
Externí odkaz:
https://doaj.org/article/2c42e591d7d54401a195223454bc2053
Publikováno v:
Journal of Pharmacological Sciences, Vol 135, Iss 2, Pp 72-80 (2017)
We reported that high-mobility group Box-1 (HMGB1) was involved in excitoneurotoxicity in the retina. HMGB1 is known to activate nuclear factor kappa B (NF-κB). However, the role of NF-κB in excitotoxicity is still controversial. Here, we demon
Externí odkaz:
https://doaj.org/article/b4b3ee6293d542bfbbd85d083189269d
Autor:
Yuki Kurauchi, Koichi Mokudai, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Masahiko Morita, Ayako Kamimura, Kunio Ishii
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 3, Pp 146-155 (2017)
l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) production. Migraine is one of the most popular neurovascular disorder, and imbalance of cerebral blood flow (CBF) observed
Externí odkaz:
https://doaj.org/article/f11434366b5e4a7cb599293d9c0039c2
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 2, Pp 107-118 (2015)
Retinal blood flow insufficiency due to capillary loss induces hypoxia in the retina, leading to an abnormal angiogenesis, relating to ischemic retinopathy. To better understand the mechanism and process of retinal capillary regression, we examined t
Externí odkaz:
https://doaj.org/article/aed57f756784424f95a418682b1b2e30
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 4, Pp 419-423 (2015)
l-Citrulline is an effective precursor of l-arginine produced by the l-citrulline/l-arginine cycle, and it exerts beneficial effects on the cardiovascular system by supporting enhanced nitric oxide (NO) production. NO dilates retinal blood vessels vi
Externí odkaz:
https://doaj.org/article/afb5b2598066467a99653b0e74a01cc1
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 2, Pp 211-216 (2015)
Previous studies have shown that degeneration of retinal capillaries occurs following N-methyl-d-aspartate (NMDA)-induced retinal neurotoxicity, but it is unclear whether vasodilatory mechanisms are altered in retinal blood vessels. The purpose of th
Externí odkaz:
https://doaj.org/article/3c47d83858fc4cc2bfcde306487c449d
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 2, Pp 79-84 (2013)
Increasing evidence suggests that the complex interactions among multiple cell types including neuronal, glial, and vascular cells, are critical for maintaining adequate cerebral blood flow that is necessary for normal brain function and survival. Th
Externí odkaz:
https://doaj.org/article/8c3f335c8bfe47999e9542800b0c6004
Publikováno v:
Journal of Pharmacological Sciences, Vol 112, Iss 3, Pp 336-342 (2010)
We previously reported that acetylcholine (ACh)–induced vasodilation of retinal arterioles is diminished in diabetic rats; however, the underlying mechanism(s) of this phenomenon has not been fully elucidated. To determine the role of the polyol pa
Externí odkaz:
https://doaj.org/article/a81bc4a5ba37481ca563bfaffac59c74