Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kunio Hosaka"'
Publikováno v:
Biological and Pharmaceutical Bulletin. 22:471-475
In this study, the cytotoxic activity of gallic acid derivatives (GDs) was studied using some cancer cell lines. Among them, 3,4-methylenedioxyphenyl 3,4,5-trihydroxybenzoate (GD-1) and S-(3,4-methylenedioxyphenyl)-3,4,5-trihydroxy-thiobenzoate (GD-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cea825c5df092610c4ab73d0c665617
https://doi.org/10.1248/bpb.22.471
https://doi.org/10.1248/bpb.22.471
Publikováno v:
ChemInform. 23
(Z)-3-Butylidene-4-hydroxyphthalide (5) was first synthesized regio- and stereoselectively from 3-methoxybenzyl alcohol (1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::664141986571add5bd84103deddc51fc
https://doi.org/10.1002/chin.199217143
https://doi.org/10.1002/chin.199217143
Autor:
Masao, Toshitsugu Sato, Yuka Okui, Kunio Hosaka, Yoshihiro Hasegawa, Hiroshi Mitsuhashi, Toshihiko Yanagisawa
Publikováno v:
ChemInform. 23
2,4-Diamino-[E]-6-[2-(3-pyridyl)ethenyl]-1,3,5-triazine (3a), leukotriene C4 (LTC4) antagonist, was found to possess a protective effect on HCl.ethanol-induced gastric lesions. Analogues of 3a were synthesized and evaluated for the effect as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b159d78d7cad7688dd78e92c28f61f3
https://doi.org/10.1002/chin.199242186
https://doi.org/10.1002/chin.199242186
Publikováno v:
ChemInform. 25
The utility of lead tetraacetate as a reagent for the monoacetoxylation of a methylenedioxy group in dimethyl 4,4'-dimethoxy-2,3,2'3'-bismethylenedioxy-1,1'-biphenyl-6,6'-dicarboxylate (1a) is demonstrated. Mechanistic feature of the monoacetoxylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b512b7dea2e912a503511347b453d0b4
https://doi.org/10.1002/chin.199412183
https://doi.org/10.1002/chin.199412183
Publikováno v:
Life Sciences. 49:1871-1878
Diuretic properties of a synthetic lignan, 2,3-dibenzylbutane-1,4-diol (hattalin), and a naturally occurring arctigenin were examined in BALB/c male mice and Wistar male rats. Intra peritoneal administration of hattalin (50 mg/kg) in mice increased u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d81cba5f5bf4fb1ad3d5ffbfc8ff820
https://doi.org/10.1016/0024-3205(91)90287-l
https://doi.org/10.1016/0024-3205(91)90287-l
Autor:
Kunio Hosaka, Toshihiko Hirano, Kitaro Oka, Takashi Naito, Yasuhiro Matsumoto, Katsushi Fukuoka, Hiroshi Mitsuhashi
Publikováno v:
Cancer Investigation. 8:595-602
The effect of each of twelve mammalian lignan derivatives on the growth of human mammary tumor ZR-75-1 cells was examined. At a concentration less than 10 micrograms/ml, tumor cell growth was inhibited from 18-68%. The effect of 2,3-dibenzylbutane-1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816f275fadb439ba9be43cd8c5718410
https://doi.org/10.3109/07357909009018926
https://doi.org/10.3109/07357909009018926
Autor:
Kunio Hosaka, Masao, Toshihiko Yanagisawa, Toshitsugu Sato, Yuka Okui, Yoshihiro Hasegawa, Hiroshi Mitsuhashi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 39:3180-3182
2,4-Diamino-[E]-6-[2-(3-pyridyl)ethenyl]-1,3,5-triazine (3a), leukotriene C4 (LTC4) antagonist, was found to possess a protective effect on HCl.ethanol-induced gastric lesions. Analogues of 3a were synthesized and evaluated for the effect as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2858148e6ac44b88e196a94d013e4641
https://doi.org/10.1248/cpb.39.3180
https://doi.org/10.1248/cpb.39.3180
Publikováno v:
Tetrahedron Letters. 19:2959-2962
Intramolecular cyclisation of the trifluoromethanesulphonate esters of the β-(4-hydroxy-n-butyl)-pyrroles (5a) and (5b) in each case yields a mixture of the α- and β-alkylated products whereas exclusive β-alkylation is observed for the β-(5-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9430eb42d71904421d92556dfb58bb48
https://doi.org/10.1016/s0040-4039(01)94911-1
https://doi.org/10.1016/s0040-4039(01)94911-1
Autor:
Yasuji Yamada, Kunio Hosaka, Kazuo Iguchi, Yasumasa Tsukitani, Haruo Horiai, Hiroyuki Kikuchi, Fumio Shibayama, Sukeji Suzuki
Publikováno v:
Chemical and Pharmaceutical Bulletin. 27:2394-2397
Two cembranolide diterpenes were isolated from the Japanese soft coral Lobophytum pauciflorum (Ehrenberg). The structures of these diterpenes were identified as I and II, involving a 13-membered carbocyclic ring system unique in the soft coral litera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3d41600cfea4aaf74b9d4414cb6367
https://doi.org/10.1248/cpb.27.2394
https://doi.org/10.1248/cpb.27.2394
Publikováno v:
Journal of the Mass Spectrometry Society of Japan. 22:217-224
Mass spectra of p-quinol derivatives were measured. The fragmentation patterns were discussed on the basis of the high resolution data, metastable ions and deuterium labeling of the hydroxyl group of p-quinols.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f86e9a97bb0b1206ee4cdd94ae9d46dd
https://doi.org/10.5702/massspec1953.22.217
https://doi.org/10.5702/massspec1953.22.217