Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kunio Hirano"'
Autor:
Li-Tao Cheng, Shogo Nagata, Kunio Hirano, Shinpei Yamaguchi, Shigeo Horie, Justin Ainscough, Takashi Tada
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32018 (2012)
Induced pluripotent stem cells (iPSCs) generated by epigenetic reprogramming of personal somatic cells have limited therapeutic capacity for patients suffering from genetic disorders. Here we demonstrate restoration of a genomic mutation heterozygous
Externí odkaz:
https://doaj.org/article/96edbfe235e54584bcd6b72d7b21967b
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48699 (2012)
Human induced pluripotent stem cells (iPSCs) are reprogrammed by transient expression of transcription factors in somatic cells. Approximately 1% of somatic cells can be reprogrammed into iPSCs, while the remaining somatic cells are differentially re
Externí odkaz:
https://doaj.org/article/c9e49c29a3884879b4f18fdac9e719a2
Autor:
Hiromi Nagashima, Yu Utsumi, Tamotsu Sugai, Kazuhiro Yakuwa, Masachika Akiyama, Kunio Hirano, Hideomi Sato, Shinji Chiba, Makoto Maemondo
Publikováno v:
Annals of Palliative Medicine. 11:2745-2750
Meningeal carcinomatosis in lung cancer is known to have a very poor prognosis. Here we report a case in which bevacizumab plus erlotinib (BE) was effective against meningeal carcinomatosis from afatinib-resistant EGFR mutation-positive lung cancer.
Autor:
Satoru Morimoto, Koichi Saeki, Masaru Takeshita, Kunio Hirano, Mariko Shirakawa, Yumiko Yamada, Shiho Nakamura, Fumiko Ozawa, Hideyuki Okano
Publikováno v:
Genes to cells : devoted to molecularcellular mechanismsREFERENCES.
The coronavirus disease 2019 (COVID-19) epidemic remains worldwide. The usefulness of the intranasal vaccine and boost immunization against severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) has recently received much attention. We de
Publikováno v:
Genes to cells : devoted to molecularcellular mechanismsREFERENCES. 24(10)
Analysis of gene expression in single cells is required to understand somatic cell reprogramming into human induced pluripotent stem cells (iPSCs). To facilitate this, we established intermediately reprogrammed stem cells (iRSCs), pre-iPSC lines. The
Autor:
Takashi Osumi, Hidetoshi Kotera, Liu Li, Taku Matsumura, Atsuhito Okonogi, Kazuya Tatsumi, Yuichiro Noda, Naoyuki Nakanishi, Kunio Hirano, Takashi Tada
Publikováno v:
Biochemical and Biophysical Research Communications. 453:131-137
The microenvironment of cells, which includes basement proteins, shear stress, and extracellular stimuli, should be taken into consideration when examining physiological cell behavior. Although microfluidic devices allow cellular responses to be anal
Autor:
Alexander Turner, Shuhei Konagaya, Yuichiro Noda, Shigeru Kitamura, Hiroo Iwata, Hidetoshi Kotera, Kunio Hirano
Publikováno v:
Biochemical and biophysical research communications. 487(2)
Human pluripotent stem cells (hPSCs) are thought to be a promising cell-source solution for regenerative medicine due to their indefinite proliferative potential and ability to differentiate to functional somatic cells. However, issues remain with re
Autor:
Chikahiko Koeda, Shohei Yamaya, Karera Mukunoki, Kunio Hirano, Iwao Goto, Maiko Hozawa, Kan Takahashi, Masanobu Niyama
Publikováno v:
Journal of Clinical Case Reports.
Nowadays, purulent pericarditis (PP) has become a rare disease with the increased use of antibiotics in clinical practices. The outcome of PP is poor due to severe infection and haemodynamic failure by the inhibition of the ventricle repletion, and n
Publikováno v:
Stem cell research. 6(2):177-186
Induced pluripotent stem cells (iPSCs) are generated by directly reprogramming somatic cells by forcing them to express the exogenous transcription factors, Oct4, Sox2, Klf4 and c-Myc (OSKM). These cells could potentially be used in clinical applicat
Autor:
Hatsune Makino, Akihiro Umezawa, Kunio Hirano, Hajime Okita, Shogo Nagata, Yoshitaka Miyagawa, Masato Nakagawa, Masashi Toyoda, Shinpei Yamaguchi, Shinya Yamanaka, Hidenori Akutsu, Nobutaka Kiyokawa, Koichiro Nishino, Takashi Tada
Publikováno v:
Genes to Cells. 14:1395-1404
Practical clinical applications for current induced pluripotent stem cell (iPSC) technologies are hindered by very low generation efficiencies. Here, we demonstrate that newborn human (h) and mouse (m) extra-embryonic amnion (AM) and yolk-sac (YS) ce