Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Kunio Nagashima"'
Autor:
Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop
Publikováno v:
eLife, Vol 12 (2023)
Ciliopathies manifest from sensory abnormalities to syndromic disorders with multi-organ pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell death is a major cause of incurable blindness in retinal ciliopathies. To
Externí odkaz:
https://doaj.org/article/d7b516710de643d58647394ef7678b1a
Autor:
Sylvain Laverdure, Ziqiu Wang, Jun Yang, Takuya Yamamoto, Tima Thomas, Toyotaka Sato, Kunio Nagashima, Tomozumi Imamichi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Interleukin-27 (IL-27) is a cytokine that suppresses human immunodeficiency virus (HIV)-1 infection in macrophages and is considered as an immunotherapeutic reagent for infectious diseases. It is reported that IL-27 suppresses autophagy in M
Externí odkaz:
https://doaj.org/article/55569853dea542f185d3d806065218a4
Autor:
Govind Kunduri, Si-Hung Le, Valentina Baena, Nagampalli Vijaykrishna, Adam Harned, Kunio Nagashima, Daniel Blankenberg, Izumi Yoshihiro, Kedar Narayan, Takeshi Bamba, Usha Acharya, Jairaj K Acharya
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001599 (2022)
Cell division, wherein 1 cell divides into 2 daughter cells, is fundamental to all living organisms. Cytokinesis, the final step in cell division, begins with the formation of an actomyosin contractile ring, positioned midway between the segregated c
Externí odkaz:
https://doaj.org/article/11250b7e906e4b6e859af1a3cdecb2d3
Autor:
Matthew J. Brooks, Holly Y. Chen, Ryan A. Kelley, Anupam K. Mondal, Kunio Nagashima, Natalia De Val, Tiansen Li, Vijender Chaitankar, Anand Swaroop
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 891-905 (2019)
Summary: Stem cell-derived retinal organoids recapitulate many landmarks of in vivo differentiation but lack functional maturation of distinct cell types, especially photoreceptors. Using comprehensive temporal transcriptome analyses, we show that tr
Externí odkaz:
https://doaj.org/article/55d75f04bc144eb088aab1172e9f26fa
Autor:
Mitsuhiro Endoh, Masaya Baba, Tamie Endoh, Akiyoshi Hirayama, Ayako Nakamura-Ishizu, Terumasa Umemoto, Michihiro Hashimoto, Kunio Nagashima, Tomoyoshi Soga, Martin Lang, Laura S. Schmidt, W. Marston Linehan, Toshio Suda
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1823-1834.e5 (2020)
Summary: The tumor suppressor folliculin (FLCN) suppresses nuclear translocation of TFE3, a master transcription factor for lysosomal biogenesis, via regulation of amino-acid-sensing Rag GTPases. However, the importance of this lysosomal regulation i
Externí odkaz:
https://doaj.org/article/3b9e850e1d30466c9177e85db8779dca
Autor:
Hiroko Shimada, Quanlong Lu, Christine Insinna-Kettenhofen, Kunio Nagashima, Milton A. English, Elizabeth M. Semler, Jacklyn Mahgerefteh, Artur V. Cideciyan, Tiansen Li, Brian P. Brooks, Meral Gunay-Aygun, Samuel G. Jacobson, Tiziana Cogliati, Christopher J. Westlake, Anand Swaroop
Publikováno v:
Cell Reports, Vol 20, Iss 2, Pp 384-396 (2017)
Mutations in CEP290, a transition zone protein in primary cilia, cause diverse ciliopathies, including Leber congenital amaurosis (LCA) and Joubert-syndrome and related disorders (JSRD). We examined cilia biogenesis and function in cells derived from
Externí odkaz:
https://doaj.org/article/7871d566c1dd4481b15cfbb020326265
Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity
Autor:
Kazuaki Monde, Hiromi Terasawa, Yusuke Nakano, Ferri Soheilian, Kunio Nagashima, Yosuke Maeda, Akira Ono
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background Human endogenous retroviruses (HERVs), the remnants of ancient retroviral infections, constitute approximately 8% of human genomic DNA. Since HERV-K Gag expression is induced by HIV-1 Tat in T cells, induced HERV-K proteins could
Externí odkaz:
https://doaj.org/article/c46931b9853345b8a53d6d300415ab46
Autor:
Valentina Baena, Ryan Conrad, Patrick Friday, Ella Fitzgerald, Taeeun Kim, John Bernbaum, Heather Berensmann, Adam Harned, Kunio Nagashima, Kedar Narayan
Publikováno v:
Viruses, Vol 13, Iss 4, p 611 (2021)
The visualization of cellular ultrastructure over a wide range of volumes is becoming possible by increasingly powerful techniques grouped under the rubric “volume electron microscopy” or volume EM (vEM). Focused ion beam scanning electron micros
Externí odkaz:
https://doaj.org/article/62e778add7da4f09afbfd0f2c2a9e0c9
Autor:
Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam K Mondal, Hyun Beom Song, Laura Campello, Gregory J Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2140ff55ea36b5c6f2347a8d42639c39
https://doi.org/10.7554/elife.83205.sa2
https://doi.org/10.7554/elife.83205.sa2
Adenosine A2A Receptor Activation Enhances Blood–Tumor Barrier Permeability in a Rodent Glioma Model
Autor:
Jessica Bills, Meili Zhang, Dionne Davis, Monica Manglani, Kunio Nagashima, Stuart Walbridge, Brandon Foster, Dorian B. McGavern, Priya Shankarappa, Amélie Vézina, DreeAnna Morris, Matthew McCord, Hua Song, Jessica Kindrick, William D. Figg, Wei Zhang, Leslie L. Muldoon, Sadhana Jackson, Mark R. Gilbert, Cody J. Peer
Publikováno v:
Mol Cancer Res
The blood–tumor barrier (BTB) limits the entry of effective chemotherapeutic agents into the brain for treatment of malignant tumors like glioblastoma. Poor drug entry across the BTB allows infiltrative glioma stem cells to evade therapy and develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f94ac14946ad5afcef38a0ddff53d7
https://doi.org/10.1158/1541-7786.mcr-19-0995
https://doi.org/10.1158/1541-7786.mcr-19-0995