Výsledky vyhledávání - "Kunio, Ohkuma"

Effects of Recombinant Cholera Toxin B Subunit (rCTB) on Cellular Immune Responses: Enhancement of Delayed-Type Hypersensitivity Following Intranasal Co-Administration ofMycobacterium bovis-BCG with rCTB

Autor: Kunio Ohkuma, Kunio Tochikubo, Saburo Yamamoto, Norihisa Goto, Yoko Yasuda, Keiko Matano, Masanori Isaka, Jun-ichi Maeyama, Kazunori Morokuma

Publikováno v: Microbiology and Immunology. 48:457-463

Recombinant cholera toxin B subunit (rCTB) is a safe and potent mucosal adjuvant. To gain insight into the mechanism underlying the adjuvant effect of rCTB, the effects of rCTB on cell-mediated immune responses of mice and guinea pigs were examined a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e2ad9fd3d138c92cdb82ba6672f28
https://doi.org/10.1111/j.1348-0421.2004.tb03536.x

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PORE-SIZE CONTROLLED AND POLY(?-LYSINE)-IMMOBILIZED CELLULOSE SPHERICAL PARTICLES FOR REMOVAL OF LIPOPOLYSACCHARIDES

Autor: Masami Todokoro, Masashi Kunitake, Masayo Sakata, Kunio Ohkuma, Satoshi Matama, Chuichi Hirayama

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 25:601-614

Poly(ϵ-lysine) was covalently immobilized onto cellulose spherical particles and used for selective adsorption of pyrogenic lipopolysaccharides (LPS) from protein solutions. The resulting poly(ϵ-lysine)-immobilized cellulose particles (PL-cellulose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0681725ae554271bf38d7eafbc0c97d0
https://doi.org/10.1081/jlc-120003349

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Cytokine Responses to Recombinant Cholera Toxin B Subunit Produced byBacillus brevisas a Mucosal Adjuvant

Autor: Kunio Ohkuma, Satoshi Kozuka, Norihisa Goto, Jun-ichi Maeyama, Keiko Matano, Yoko Yasuda, Kunio Tochikubo, Masanori Isaka, Tooru Taniguchi

Publikováno v: Microbiology and Immunology. 45:111-117

We attempted to clarify the mechanism of the mucosal adjuvanticity of recombinant cholera toxin B subunit (rCTB), which is inherently uncontaminated with the holotoxin produced by Bacillus brevis and has a powerful mucosal adjuvant activity, on cytok

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b92ecc45c91beed93b6ffc864b4789
https://doi.org/10.1111/j.1348-0421.2001.tb01276.x

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Induction of systemic and mucosal antibody responses in mice immunized intranasally with aluminium-non-adsorbed diphtheria toxoid together with recombinant cholera toxin B subunit as an adjuvant

Autor: Kunio Ohkuma, Tooru Taniguchi, Keiko Matano, Kunio Tochikubo, Takako Komiya, Satoshi Kozuka, Jun-ichi Maeyama, Norihisa Goto, Yoko Yasuda, Masanori Isaka

Publikováno v: Vaccine. 18:743-751

Nasal mucosal immunization is very attractive for vaccination to prevent various bacterial and viral infectious diseases because of induction of systemic and mucosal immune responses. The aim of the present study was to investigate the possibility of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3146e83bbc1f90c586c5e7846c1d442
https://doi.org/10.1016/s0264-410x(99)00258-3

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Pore-Size Controlled and Aminated Poly(γ-methyl L-glutamate) Particles for Selective Removal of Nucleic Acids

Autor: Ken Moriguchi, Chuichi Hirayama, Masayo Sakata, Hirotaka Ihara, Kunio Ohkuma, Hiroshi Mizokami

Publikováno v: Scopus-Elsevier

This report describes a method for selective removal of nucleic acids from various protein solutions, using aminated poly(γ-methyl L-glutamate) (PMLG-NH2) particles. The adsorbing activity for nucleic acids (purified DNA from salmon spermary) increa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea47f793c37a1179e7a3b37cc7c5be0
https://doi.org/10.1295/polymj.30.616

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An immunogenicity and efficacy study of purified chick embryo cell culture rabies vaccine manufactured in Japan

Autor: Tetsuya Oka, Ampai Bangjongkasaena Na Ayuthya, Ponsri Samranwetaya, Penmas Thipkong, Nipa Naraporn, Pakamatz Khawplod, Kunio Ohkuma, Maneerat Benjavongkulchai, Somsri Raksakate, Chartchai Kositprapa, Takashi Hamasaki, Chawtip Yountong, Henry Wilde, Kornvika Limsuwun, Pranee Chomchey

Publikováno v: Vaccine. 15:1816-1819

Purified chick embryo cell rabies vaccine manufactured by the Chemo-Sero-Therapeutic Institute(Kaketsuken) at Kumamoto, Japan (Kaketsuken) was submitted to an immunogenicity and efficacy study. 52 severely rabies exposed patients were treated with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b6f6e5412828080957e1b05557fde6
https://doi.org/10.1016/s0264-410x(97)00143-6

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The removal of endotoxins from protein solutions using column packings with aminated poly (γ-methyl L-glutamate) spheres

Autor: Masayo Sakata, Y. Miyachi, H. Tachibe, Chuichi Hirayama, Sunao Morimoto, Kunio Ohkuma, Hirotaka Ihara

Publikováno v: Chromatographia. 40:33-38

A method is described for the selective removal of endotoxins from various protein solutions using columns packed with aminated poly (γ-methyl L-glutamate) (PMLG-NH2) spheres. The PMLG-NH2 adsorbents showed a high adsorbing activity for endotoxins w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c66968e7fd8c1d1c41b8d6097140a91
https://doi.org/10.1007/bf02274604

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