Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kuninori Tai"'
Autor:
Emiliano Tamanini, Shin Miyamura, Ildiko M. Buck, Benjamin D. Cons, Lee Dawson, Charlotte East, Takashi Futamura, Shintaro Goto, Charlotte Griffiths-Jones, Tetsuya Hashimoto, Tom D. Heightman, Shunpei Ishikawa, Hideki Ito, Yosuke Kaneko, Tatsuya Kawato, Kazumi Kondo, Naoki Kurihara, James M. McCarthy, Yukiko Mori, Tsuyoshi Nagase, Yuichiro Nakaishi, Judith Reeks, Akimasa Sato, Patrick Schöpf, Kuninori Tai, Taichi Tamai, Dominic Tisi, Alison J.-A. Woolford
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1591-1597
Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2. In addition to the anticipated hydroxamic acid- and benzamide-based fragment screening hits, a low affinity (∼1 mM) α-amino-amide zinc binding fragment was iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a51f121f3406b6de752dce46b777833
https://doi.org/10.1021/acsmedchemlett.2c00272
https://doi.org/10.1021/acsmedchemlett.2c00272
Autor:
Takeshi Imanishi, Hidenobu Murafuji, Hiroshi Iwaki, Kazuyuki Miyashita, Naoko Sasaki, Kuninori Tai
Publikováno v:
Tetrahedron. 57:5773-5780
Regio- and stereoselective α-alkylation of N-terminal amino acid residue of peptides was achieved by Li+-mediated alkylation of aldimines prepared from the peptides and a pyridoxal model compound having a chiral ansa-structure and an ethoxyethoxy gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ade1b49701fdf50746c3c93a5ab80678
https://doi.org/10.1016/s0040-4020(01)00512-9
https://doi.org/10.1016/s0040-4020(01)00512-9
Publikováno v:
Tetrahedron. 56:4691-4700
Stereoselective alkylation of aldimines, prepared from α-amino esters and a pyridoxal model having a chiral ansa-structure and an ethoxyethoxy group at C-3, proceeded in the presence of Li + to give α,α-dialkyl amino esters after acidic hydrolysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05f57001e7019693e883a6c61f67ea95
https://doi.org/10.1016/s0040-4020(00)00392-6
https://doi.org/10.1016/s0040-4020(00)00392-6
Autor:
Chiaki Kurozumi, Hideto Miyabe, Kuninori Tai, Kazuyuki Miyashita, Hiroshi Iwaki, Takeshi Imanishi
Publikováno v:
Tetrahedron. 55:12109-12124
Stereoselective alkylation of aldimines, prepared from α-amino esters and pyridoxal models having an ionophoric side-chain composed of a chiral glycerol structure, proceeded in the presence of Li+ or Na+ to afford α,α-dialkyl amino esters after ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7babf22d73efba8c0a21d4040f72e13b
https://doi.org/10.1016/s0040-4020(99)00708-5
https://doi.org/10.1016/s0040-4020(99)00708-5
Publikováno v:
Tetrahedron. 52:12125-12136
Synthesis of α,α-dialkyl-α-amino esters by α-alkylation of aldimines prepared from a novel pyridoxal model compound was studied. The α-alkylation of the aldimines having an ethoxy-ethoxy group at C-3 proceeded most rapidly when LiOH was employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::416f45f79ea8e07be961362728deee0d
https://doi.org/10.1016/0040-4020(96)00704-1
https://doi.org/10.1016/0040-4020(96)00704-1
Publikováno v:
ChemInform. 27
Asymmetric α-alkylation of α-amino esters by use of novel pyridoxal model compounds having a chiral ionophore function is studied; the stereoselectivity is specifically induced by Na+ and the most effective asymmetric induction occurs with a combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4a176c693a688a1784f615d1e1c614
https://doi.org/10.1002/chin.199637259
https://doi.org/10.1002/chin.199637259
Publikováno v:
ChemInform. 28
Synthesis of α,α-dialkyl-α-amino esters by α-alkylation of aldimines prepared from a novel pyridoxal model compound was studied. The α-alkylation of the aldimines having an ethoxy-ethoxy group at C-3 proceeded most rapidly when LiOH was employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca5601ac162478adef3c4705f2a27f6
https://doi.org/10.1002/chin.199705094
https://doi.org/10.1002/chin.199705094
Publikováno v:
ChemInform. 30
Stereoselective and N-terminal selective α-alkylation of peptides is achieved using a pyridoxal model compound as an N-terminal activator which also functions as a chiral auxiliary.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb0c5859e935942f9859142a82b6610
https://doi.org/10.1002/chin.199902199
https://doi.org/10.1002/chin.199902199
Autor:
Hiroshi Iwaki, Takeshi Imanishi, Kuninori Tai, Hideto Miyabe, Kazuyuki Miyashita, Chiaki Kurozumi
Publikováno v:
ChemInform. 31
Stereoselective alkylation of aldimines, prepared from α-amino esters and pyridoxal models having an ionophoric side-chain composed of a chiral glycerol structure, proceeded in the presence of Li+ or Na+ to afford α,α-dialkyl amino esters after ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54bcaba884609a65f40effc2e95500f
https://doi.org/10.1002/chin.200003194
https://doi.org/10.1002/chin.200003194
Publikováno v:
ChemInform. 31
Stereoselective alkylation of aldimines, prepared from α-amino esters and a pyridoxal model having a chiral ansa-structure and an ethoxyethoxy group at C-3, proceeded in the presence of Li + to give α,α-dialkyl amino esters after acidic hydrolysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f5f5b0f1bb967be045a41ca1b488cf
https://doi.org/10.1002/chin.200043202
https://doi.org/10.1002/chin.200043202