Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Kunimi Kikuchi"'
Autor:
Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda
Publikováno v:
Marine Drugs, Vol 4, Iss 1, Pp 9-14 (2006)
Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 a
Externí odkaz:
https://doaj.org/article/69313788837644529adee0b4295bac9a
Publikováno v:
Journal of Biochemistry. 150:483-490
Dr Tsuiki made three major contributions during his illustrious career as a biochemist. First, he developed the procedure for mucin isolation from bovine submaxillary glands. His work became the basis for mucin biochemistry. Second, he identified fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ca00e07a9061fd5517241efe8c30a0
https://doi.org/10.1093/jb/mvr045
https://doi.org/10.1093/jb/mvr045
Autor:
Ryuichi Katakura, Isao Kasugai, Kunimi Kikuchi, Takeshi Kawamura, Kentaro Takagaki, Masami Sato, Nobuhiro Tanuma, Miyuki Nomura, Ikuro Sato, Y Tsubaki, Hiroshi Shima, Yoji Yamashita, M Ikeda
Publikováno v:
ONCOGENE, 28(5), 752-761. Nature Publishing Group
Recent studies have demonstrated essential functions for KIF3, a microtubule-directed protein motor, in subcellular transport of several cancer-related proteins, including the beta-catenin-cadherin(s) complex. In this study, we report identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30331559343f3042c3e4db59a6e3612a
https://doi.org/10.1038/onc.2008.431
https://doi.org/10.1038/onc.2008.431
Autor:
Takeshi Satoh, Kunimi Kikuchi, Miyuki Nomura, Nobuhiro Tanuma, Kentaro Takagaki, Hiroshi Shima, Masahiko Watanabe
Publikováno v:
Molecular and Cellular Biochemistry. 296:177-184
Dual-specificity phosphatases (DSPs), which dephosphorylate proteins at Ser/Thr as well as Tyr residues, are thought to be involved in critical signaling events such as control of MAP kinases (MAPKs). We have isolated the cDNA for a novel DSP and ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4ce40fcf7727fdfc3f2a89c79b0e70
https://doi.org/10.1007/s11010-006-9313-5
https://doi.org/10.1007/s11010-006-9313-5
Autor:
Tadashi Okada, Hiroshi Shima, Shinya Mitsuhashi, Naohito Aoki, Takaaki Kubota, Kunimi Kikuchi, Yusuke Wakuda, Jun'ichi Kobayashi
Publikováno v:
Marine Drugs
Marine Drugs, Vol 4, Iss 1, Pp 9-14 (2006)
Marine Drugs, Vol 4, Iss 1, Pp 9-14 (2006)
Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f20785ee2f6b46e6afd7cf28fcebba
https://doi.org/10.3390/md401009
https://doi.org/10.3390/md401009
Publikováno v:
Cancer Letters. 226:155-160
In this study, we focus on the potential interaction of pp32/I-1(PP2A) (pp32) with the Raf-MEK-ERK signaling pathway. We show that overexpressed pp32 suppresses Raf-1 activation, thereby downregulating the level of ERK activation. This suppression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123489374bed653675d21150fc21d4fe
https://doi.org/10.1016/j.canlet.2004.11.026
https://doi.org/10.1016/j.canlet.2004.11.026
Autor:
Hiroshi Shima, Yoshio Araki, Takeshi Urano, Kouhei Masuda, Chiaki Katagiri, Katsumi Yamashita, Kunimi Kikuchi
Publikováno v:
Journal of Biological Chemistry. 280:14716-14722
MAPK cascades can be negatively regulated by members of the MAPK phosphatase (MKP) family. However, how MKP activity is regulated is not well characterized. MKP-7, a JNK-specific phosphatase, possesses a unique COOH-terminal stretch (CTS) in addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b8260e1f4c0fd567b344c8a2a7dc3
https://doi.org/10.1074/jbc.m500200200
https://doi.org/10.1074/jbc.m500200200
Autor:
Kunimi Kikuchi, Hiroshi Shima, Sumie Sasa, Kazunori Onoé, Nobuhiro Tanuma, Makoto Ubukata, Shinya Mitsuhashi
Publikováno v:
Molecular and Cellular Biochemistry. 269:183-187
The interleukin-6 (IL-6) stimulates growth in cells such as multiple myeloma and B-cell plasmacytomas/hybridomas, while it inhibits growth in several myeloid leukemia cells. The IL-6 receptor has subunit called gp130. It was reported that Ser-782 of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134d654409d623b7f1e095a0b40bd298
https://doi.org/10.1007/s11010-005-3089-x
https://doi.org/10.1007/s11010-005-3089-x
Publikováno v:
Genes & Genetic Systems. 69:697-700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8b5327953553fdac07cac61bcb12b44
https://doi.org/10.1266/ggs.69.697
https://doi.org/10.1266/ggs.69.697
Autor:
Nobuyasu Matsuura, Shinya Mitsuhashi, Kunimi Kikuchi, Hiroshi Shima, Makoto Ubukata, Hideaki Oikawa
Publikováno v:
Biochemical and Biophysical Research Communications. 287:328-331
Here we isolated tautomycetin, TC, and examined its phosphatase inhibitory activity. Recently we have reported that the left-hand moiety of tautomycin, TM, and the right one containing the spiroketal are essentially required for inhibition of protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64677851df0d7e79c567b2127d68b76
https://doi.org/10.1006/bbrc.2001.5596
https://doi.org/10.1006/bbrc.2001.5596