Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Kunimaro Furuta"'
Autor:
Mireille Khoury, Qianqian Guo, Kunimaro Furuta, Cristina Correia, Chady Meroueh, Hyun Se Kim Lee, Khaled Warasnhe, Lucía Valenzuela-Pérez, Andrew P. Mazar, Iljung Kim, Yung-Kyun Noh, Heather Holmes, Michael F. Romero, Caroline R. Sussman, Kevin D. Pavelko, Shahidul Islam, Adebowale O. Bamidele, Petra Hirsova, Hu Li, Samar H. Ibrahim
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101073- (2024)
Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by excessive circulating toxic lipids, hepatic steatosis, and liver inflammation. Monocyte adhesion to liver sinusoidal endothelial cells (LSECs) and transend
Externí odkaz:
https://doaj.org/article/140f68733e754e61917380b70dbef94e
Autor:
Qianqian Guo, Kunimaro Furuta, Shahidul Islam, Nunzia Caporarello, Enis Kostallari, Kobe Dielis, Daniel J. Tschumperlin, Petra Hirsova, Samar H. Ibrahim
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundDuring liver injury, liver sinusoidal endothelial cells (LSECs) dysfunction and capillarization promote liver fibrosis. We have previously reported that the LSEC vascular cell adhesion molecule 1 (VCAM1) plays a key role in liver inflammati
Externí odkaz:
https://doaj.org/article/0f34dfa9264a48788a0d34ae5e8f906e
Autor:
Tomohide Kurahashi, Yuichi Yoshida, Satoshi Ogura, Mayumi Egawa, Kunimaro Furuta, Hayato Hikita, Takahiro Kodama, Ryotaro Sakamori, Shinichi Kiso, Yoshihiro Kamada, I-Ching Wang, Hidetoshi Eguchi, Eiichi Morii, Yuichiro Doki, Masaki Mori, Vladimir V. Kalinichenko, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)
Background & Aims: Liver inflammation has been recognized as a hallmark of hepatocarcinogenesis. Although Forkhead Box M1 (FoxM1) is a well-defined oncogenic transcription factor that is overexpressed in hepatocellular carcinoma (HCC), its role in li
Externí odkaz:
https://doaj.org/article/5ba2358818af4cb5928d97ec632e1731
Autor:
Luz Helena Gutierrez Sanchez, Kyoko Tomita, Qianqian Guo, Kunimaro Furuta, Husam Alhuwaish, Petra Hirsova, Saurabh Baheti, Bonnie Alver, Ryan Hlady, Keith D. Robertson, Samar H. Ibrahim
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1493-1512 (2018)
With the epidemic of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common pediatric liver disease. The influence of a perinatal obesity‐inducing diet (OID) on the development and progression of NAFLD in offspring is importan
Externí odkaz:
https://doaj.org/article/76512175caa345c4adc44cee5e560bfa
Autor:
Takahiro Suda, Tomohide Tatsumi, Akira Nishio, Tadashi Kegasawa, Teppei Yoshioka, Ryoko Yamada, Kunimaro Furuta, Takahiro Kodama, Minoru Shigekawa, Hayato Hikita, Ryotaro Sakamori, Takasuke Fukuhara, Yoshiharu Matsuura, Tetsuo Takehara
Publikováno v:
Hepatology Communications, Vol 2, Iss 10, Pp 1247-1258 (2018)
Natural killer cells (NK cells) play an essential role in the immunological mechanism underlying chronic hepatitis C (CHC). Impairment of NK cell function facilitates persistent infection with hepatitis C virus (HCV) and hepatocellular carcinogenesis
Externí odkaz:
https://doaj.org/article/65d403062b09423f9034ffca652a172f
Autor:
Yuki Tahata, Ryotaro Sakamori, Ayako Urabe, Naoki Morishita, Ryoko Yamada, Takayuki Yakushijin, Naoki Hiramatsu, Yoshinori Doi, Akira Kaneko, Hideki Hagiwara, Yukinori Yamada, Taizo Hijioka, Masami Inada, Shinji Tamura, Yasuharu Imai, Kunimaro Furuta, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara
Publikováno v:
Hepatology Communications, Vol 2, Iss 8, Pp 888-896 (2018)
Combination treatment of ledipasvir and sofosbuvir (LDV/SOF) is first‐line treatment for patients with chronic hepatitis C genotype 1 in the United States, Europe, and Japan. However, the influence of LDV/SOF on the cardiovascular system is poorly
Externí odkaz:
https://doaj.org/article/6628cfc9760b49e591fb8bc5c0f501b9
Publikováno v:
Biology, Vol 9, Iss 11, p 395 (2020)
Nonalcoholic steatohepatitis (NASH) has become a growing public health problem worldwide, yet its pathophysiology remains unclear. Liver sinusoidal endothelial cells (LSEC) have unique morphology and function, and play a critical role in liver homeos
Externí odkaz:
https://doaj.org/article/f76925fb031d48268e085328a97b3b8a
Autor:
Kunimaro Furuta, Xiaofang Tang, Shahidul Islam, Alonso Tapia, Zhen Bouman Chen, Samar H. Ibrahim
Publikováno v:
Pharmacology & Therapeutics. 244:108372
Publikováno v:
J Vis Exp
Liver sinusoidal endothelial cells (LSECs) are specialized endothelial cells located at the interface between the circulation and the liver parenchyma. LSECs have a distinct morphology characterized by the presence of fenestrae and the absence of bas
Autor:
Thomas Greuter, Usman Yaqoob, Can Gan, Nidhi Jalan-Sakrikar, Enis Kostallari, Jianwen Lu, Jinhang Gao, Liankang Sun, Mengfei Liu, Tejasav S. Sehrawat, Samar H. Ibrahim, Kunimaro Furuta, Katerina Nozickova, Bing Q. Huang, Bin Gao, Michael Simons, Sheng Cao, Vijay H. Shah
Publikováno v:
Journal of hepatology. 77(3)
Liver sinusoidal endothelial cells (LSECs) are ideally situated to sense stiffness and generate angiocrine programs that potentially regulate liver fibrosis and portal hypertension. We explored how specific focal adhesion (FA) proteins parlay LSEC me