Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kuniko Kiriyama"'
Degradation Kinetics and Isomerization of Cefdinir, a New Oral Cephalosporin, in Aqueous Solution. 1
Autor:
Yoshihiro Namiki, Junichi Matsushita, Mamoru Fujioka, Yoshihiko Okamoto, Kuniko Kiriyama, Tsutomu Yasuda
Publikováno v:
Journal of Pharmaceutical Sciences. 85:976-983
Hydrolytic degradation products of cefdinir were studied in acidic (pH 1), neutral (pH 6), and basic (pH 9) solutions. Seven major degradation products were isolated by preparative and/or high-performance liquid chromatography and characterized by UV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedb6dd6b4f201478e7a2c62324d2a2a
https://doi.org/10.1021/js950446r
https://doi.org/10.1021/js950446r
Autor:
Yoshihiro Namiki, Tsutomu Yasuda, Junichi Matsushita, Mamoru Fujioka, Yoshihiko Okamoto, Kuniko Kiriyama
Publikováno v:
Journal of Pharmaceutical Sciences. 85:984-989
Hydrolysis of cefdinir leads to pH-dependent isomerizations and beta-lactam ring-opening. Lactam ring opened gamma-lactones were produced as a mixture of four diastereoisomers based on the lactone methyl, and C-6 isomerizations in acidic to neutral s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e2e2ca83de2cdca0f89887fc09f7d4
https://doi.org/10.1021/js950447j
https://doi.org/10.1021/js950447j