Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kunihiro Odaguchi"'
Autor:
Tatsuo Toyoda, Koichiro Hirano, Kunihiro Odaguchi, Toshihiro Fujioka, Hayashi Kunio, Naofumi Hashimoto, Masuhisa Nakamura
Publikováno v:
Pharmaceutical Research. 11:1443-1447
Common problems in developing renin inhibitors are low solubility, insufficient oral absorption, and fast hepatic clearance. We focused on the molecular structure of renin inhibitors to overcome these problems. Cyclodextrins (CD) improved the low sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196d9eb05250324d5496dec054e3a8df
https://doi.org/10.1023/a:1018948007419
https://doi.org/10.1023/a:1018948007419
Publikováno v:
Japanese journal of pharmacology. 72(2)
We compared the effects of an anti-ulcer agent, benexate hydrochloride betadex (BHB), on prostaglandin (PG) levels in gastric tissue and inflammatory exudate in untreated and indomethacin-treated rats. BHB (100, 300 and 1000 mg/kg, p.o.) showed dose-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c3d03755c862fe999617d3b189f5d1
https://pubmed.ncbi.nlm.nih.gov/8912919
https://pubmed.ncbi.nlm.nih.gov/8912919
Publikováno v:
Japanese Journal of Pharmacology. 64:278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5659e92176827a325d7ad92c7bb51ef
https://doi.org/10.1016/s0021-5198(19)50745-4
https://doi.org/10.1016/s0021-5198(19)50745-4
Publikováno v:
Life Sciences. 27:2205-2210
Intraperitoneal injection of caerulein produced a pronounced increase in plasma corticosterone levels in intact rats. Since this effect was not observed in hypophysectomized rats, it is assumed that the peptide does not affect the adrenal gland direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917ffd16146f668a05741eb42dbb92ab
https://doi.org/10.1016/0024-3205(80)90385-9
https://doi.org/10.1016/0024-3205(80)90385-9
Autor:
Shinichi Shimamura, Masuhisa Nakamura, Koichi Yasumura, Kenji Okamoto, Haruaki Yajima, Kunihiro Odaguchi, Akira Tanaka
Publikováno v:
Chemical and Pharmaceutical Bulletin. 30:866-873
The nonatriaoontapeptide corresponding to the entire amino acid sequence of ostrich adrenocorticotropic hormone (ACTH) was synthesized by successive condensations of four peptide fragments ; Z (OMe)-(15-19)-OH, Z (OMe)-(11-14)-OH, Boc-(5-10)-OH and Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d8f659d6e376a132d8bc9718bdd923
https://doi.org/10.1248/cpb.30.866
https://doi.org/10.1248/cpb.30.866
Publikováno v:
Chemical and Pharmaceutical Bulletin. 26:1061-1065
Plasma corticosteroids level was determined after rectal administration of Gly1-α1-18 ACTH amide to hypophysectomized rat. When the aqueous solution of the peptide was administered, the corticosteroidogenic response was detected in 5 min and reached
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f292cb85900588a05e06b31707088c3
https://doi.org/10.1248/cpb.26.1061
https://doi.org/10.1248/cpb.26.1061
Publikováno v:
Endocrinologia Japonica. 26:741-744
The effect of pentagastrin on the pituitary-adrenocortical secretion was examined in male rats. In the morning the intraperitoneal injection of this peptide produced a slight, but significant, decrease in the plasma corticosterone levels, but it had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3af84a7ad08a07c51542ff8d179201
https://doi.org/10.1507/endocrj1954.26.741
https://doi.org/10.1507/endocrj1954.26.741
Publikováno v:
Acta endocrinologica. 96(4)
Tissue distribution of {Aib1, Lys17,18,19}-corticotrophin-(1-19)-nonadecapeptide amide (690024-S), iv injected to hypophysectomized rats, were surveyed by bioassay. Among the tissues examined, the largest amount of 690024-S was found in the liver dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022b2858637dbc00694c0c02191687ec
https://pubmed.ncbi.nlm.nih.gov/6259863
https://pubmed.ncbi.nlm.nih.gov/6259863
Publikováno v:
Life sciences. 25(20)
The effect of a cholecystokinin (CCK) preparation on the secretion of corticosterone when injected intraperitoneally and intraventricularly was studied in the rat. Both routes of injections produced pronounced elevation of plasma corticosterone level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1813b18d5b815999c5b41003a1cf30
https://pubmed.ncbi.nlm.nih.gov/529984
https://pubmed.ncbi.nlm.nih.gov/529984
Stimulation of corticosterone production by atrial natriuretic polypeptide in hypophysectomized rats
Publikováno v:
European Journal of Pharmacology. 117:285-286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235476651b46b16a2f2444a1331e2420
https://doi.org/10.1016/0014-2999(85)90617-x
https://doi.org/10.1016/0014-2999(85)90617-x