Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kunihiro Kaihatsu"'
Autor:
Kenji Takagi, Tenko Hayashi, Shinjiro Sawada, Miku Okazaki, Sakiko Hori, Katsuya Ogata, Nobuo Kato, Yasuhito Ebara, Kunihiro Kaihatsu
Publikováno v:
Molecules, Vol 25, Iss 4, p 769 (2020)
During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in path
Externí odkaz:
https://doaj.org/article/8ed38034e15b4f0993e8707f55a99a1d
Publikováno v:
Molecules, Vol 23, Iss 10, p 2475 (2018)
Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modific
Externí odkaz:
https://doaj.org/article/26160c66649b4952aced482a6db7a704
Publikováno v:
Molecules, Vol 22, Iss 11, p 1840 (2017)
DNA carries genetic information in its sequence of bases. Synthetic oligonucleotides that can sequence-specifically recognize a target gene sequence are a useful tool for regulating gene expression or detecting target genes. Among the many synthetic
Externí odkaz:
https://doaj.org/article/855b889e5ed249cb8eb5afb7ad72db39
Autor:
Masaki Ikeda, Manabu Ueda-Wakagi, Kaori Hayashibara, Rei Kitano, Masaya Kawase, Kunihiro Kaihatsu, Nobuo Kato, Yoshitomo Suhara, Naomi Osakabe, Hitoshi Ashida
Publikováno v:
Molecules, Vol 22, Iss 2, p 314 (2017)
It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin. In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affin
Externí odkaz:
https://doaj.org/article/2aa1207d66be45418d8dd29adeaddd71
Autor:
Kunihiro Kaihatsu, Shinjiro Sawada, Shota Nakamura, Takaaki Nakaya, Teruo Yasunaga, Nobuo Kato
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64017 (2013)
To rapidly and specifically identify highly virulent influenza virus strains, we prepared an azobenzene-tethered hairpin-type peptide nucleic acid, bisPNA-AZO, which has a complementary sequence against a highly conserved genomic RNA sequence within
Externí odkaz:
https://doaj.org/article/92320d845a224408beecc254ef154601
Autor:
Sawako Enoki, Ryota Iino, Nobuhiro Morone, Kunihiro Kaihatsu, Shouichi Sakakihara, Nobuo Kato, Hiroyuki Noji
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49208 (2012)
Here we report label-free optical imaging of single particles of the influenza virus attached on a glass surface with a simple objective-type total internal reflection dark-field microscopy (TIRDFM). The capability of TIRDFM for the imaging of single
Externí odkaz:
https://doaj.org/article/b6ddb573dfb94ac8950bd034b4e11b43
Autor:
Masakazu Suzuki, Kosuke Nakagawa, Shunsuke Sezaki, Tomohiko Murakami, Kunihiro Kaihatsu, Hitoshi Wakama, Hideki Sato, Shuhei Otsuki, Masashi Neo, Nobuhiro Okuno
Publikováno v:
The American Journal of Sports Medicine. 47:1804-1815
Background:Meniscal injury is a severe impediment to movement and results in accelerated deterioration of the knee joint.Purpose:To evaluate the effect of a novel meniscal scaffold prepared from polyglycolic acid coated with polylactic acid/caprolact
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:744-748
Sialyllactose (SL)-modified trimer DNAs with a similar SL presentation as their binding sites on influenza virus hemagglutinin (HA) trimer were designed and synthesized. These trimer DNAs showed high affinity for various influenza viruses, including
Publikováno v:
Carbohydrate Research. 474:43-50
Natural sialic acid-modified compounds are capable of targeting influenza virus hemagglutinin (HA). However, these compounds have limited inhibitory effect because natural O-glycoside bond in these compounds are prone to be cleaved by neuraminidase (
Publikováno v:
International Journal of Pharmaceutics. 541:206-213
This study sought to evaluate the antitumor effects of and elucidate the mechanisms underlying (-)-epigallocatechin-3-O-gallate (EGCG) and polyethyleneglycol (PEG)-modified liposomes. EGCG functions as a target ligand of the 67-kDa laminin receptor (