Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kunihiko Higashiura"'
Autor:
Kazuhito Furukawa, Yukari Konishi, Ko Nakamura, Masanori Otsuka, Hisashi Yago, Takashi Ogino, Kunihiko Higashiura, Kaoru Okamoto, Atsushi Yamamoto
Publikováno v:
Chemical and Pharmaceutical Bulletin. 50:47-52
To find new tachykinin NK1 receptor antagonists from natural sources, we examined the tachykinin antagonist activity in the extracts of approximately 200 species of plants by the use of isolated guinea pig ileum. As a result, we discovered a novel an
Autor:
Kunihiko Higashiura, Kazuharu Ienaga
Publikováno v:
ChemInform. 23
Autor:
Yukari Konishi, Takashi Ogino, Masanori Otsuka, Ko Nakamura, Atsushi Yamamoto, Kazuhito Furukawa, Kunihiko Higashiura, Kaoru Okamoto, Hisashi Yago
Publikováno v:
ChemInform. 33
To find new tachykinin NK1 receptor antagonists from natural sources, we examined the tachykinin antagonist activity in the extracts of approximately 200 species of plants by the use of isolated guinea pig ileum. As a result, we discovered a novel an
Publikováno v:
Brain Research. 594:347-350
Intra-amygdaloid injections of gamma-glutamyltaurine, a recently identified brain dipeptide, strongly suppressed seizures in amygdala-kindled rats stimulated with intensities 10 or 50 microA above the generalized seizure triggering threshold (mean 82
Autor:
Takayuki Kotani, Kunihiko Higashiura
Publikováno v:
Journal of medicinal chemistry. 47(11)
We have developed a rapid evaluation method, comparative molecular active site analysis (CoMASA), for obtaining 3D QSAR. CoMASA has three major advantages: (1) the CoMASA results would easily transform to pharmacophore and/or queries required for 3D
Autor:
Takayuki Kotani, Kunihiko Higashiura
Publikováno v:
Journal of chemical information and computer sciences. 42(1)
Rapid evaluation method for obtaining molecular shape similarity index using pairwise calculation of the nearest atomic distance respected to the template atoms was investigated. This method for calculations of similarity indices remarkably reduced r
Autor:
Kazuharu lenaga, Akifumi Inoue, Ko Nakamura, Kunihiko Higashiura, Naoharu Nishimura, Yoshiyuki Kurimoto, Hiroshi Kimurat, Atsushi Yamamoto
Publikováno v:
NeuroReport. 3:330-332
We had obtained some immunohistochemical indications which suggested that peptide(s) containing GABA at the C-terminal could exist in specific neurons in brains. We therefore sought such GABA conjugate(s) by isolating an acidic GABA-dipeptide from bo
Autor:
Kunihiko Higashiura, Kazuharu Ienaga
Publikováno v:
The Journal of Organic Chemistry. 57:764-766
Publikováno v:
Psychiatry and Clinical Neurosciences. 45:383-385
Antiepileptic effects of intracerebral injections of taurine and valyltaurine were examined in amygdaloid kindled rats. The effects were assessed whether the animals can evoke generalized seizures by a 10 microA higher stimulation intensity than trig
Autor:
Kazuharu Ienaga, Atsushi Yamamoto, Ko Nakamura, Hiroshi Kimura, Naoharu Nishimura, Ikuo Tooyama, Kunihiko Higashiura
Publikováno v:
Journal of neurochemistry. 55(3)
We isolated a glutamyltaurine from bovine brains and determined its structure as gamma-glutamyltaurine (gamma-Glu-Tau; glutaurine) by use of a new mass spectrometric technique [B/E linked scan sputtered ion mass spectrometry (SIMS)], which we have re