Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Kunihiko Hashimoto"'
Autor:
Kosuke Kita, Takahito Fujimori, Yuki Suzuki, Yuya Kanie, Shota Takenaka, Takashi Kaito, Takuyu Taki, Yuichiro Ukon, Masayuki Furuya, Hirokazu Saiwai, Nozomu Nakajima, Tsuyoshi Sugiura, Hiroyuki Ishiguro, Takashi Kamatani, Hiroyuki Tsukazaki, Yusuke Sakai, Haruna Takami, Daisuke Tateiwa, Kunihiko Hashimoto, Tomohiro Wataya, Daiki Nishigaki, Junya Sato, Masaki Hoshiyama, Noriyuki Tomiyama, Seiji Okada, Shoji Kido
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107900- (2023)
Summary: We proposed a bimodal artificial intelligence that integrates patient information with images to diagnose spinal cord tumors. Our model combines TabNet, a state-of-the-art deep learning model for tabular data for patient information, and a c
Externí odkaz:
https://doaj.org/article/da9530a80d524da8b0e3b8ae70fa06cc
Autor:
Joe Kodama, Anjar Anggraini Harumningtyas, Tomoko Ito, Miroslav Michlíček, Satoshi Sugimoto, Hidekazu Kita, Ryota Chijimatsu, Yuichiro Ukon, Junichi Kushioka, Rintaro Okada, Takashi Kamatani, Kunihiko Hashimoto, Daisuke Tateiwa, Hiroyuki Tsukazaki, Shinichi Nakagawa, Shota Takenaka, Takahiro Makino, Yusuke Sakai, David Nečas, Lenka Zajíčková, Satoshi Hamaguchi, Takashi Kaito
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Regeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited availability of autograft material, the use of artificial bone is prevalent; however,
Externí odkaz:
https://doaj.org/article/b20d6767af774235b79c8b38f1f283c1
Autor:
Akito Morimoto, Junichi Kikuta, Keizo Nishikawa, Takao Sudo, Maki Uenaka, Masayuki Furuya, Tetsuo Hasegawa, Kunihiko Hashimoto, Hiroyuki Tsukazaki, Shigeto Seno, Akira Nakamura, Daisuke Okuzaki, Fuminori Sugihara, Akinori Ninomiya, Takeshi Yoshimura, Ryoko Takao-Kawabata, Hideo Matsuda, Masaru Ishii
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors show that SLPI regulates the communication between osteoblasts and osteoclasts to promote the anabolic effect of parat
Externí odkaz:
https://doaj.org/article/80eb5385981346dea70479fd2d735e0d
Autor:
Daisuke Tateiwa, Takashi Kaito, Kunihiko Hashimoto, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Hiroyuki Tsukazaki, Shinichi Nakagawa, Yuichiro Ukon, Hiromasa Hirai, Hongying Tian, Ivan Alferiev, Michael Chorny, Satoru Otsuru, Seiji Okada, Masahiro Iwamoto
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Bone morphogenetic proteins (BMPs) have been clinically applied for induction of bone formation in musculoskeletal disorders such as critical-sized bone defects, nonunions, and spinal fusion surgeries. However, the use of supraphysiological doses of
Externí odkaz:
https://doaj.org/article/cdcc23b661c84c68831b00771c017cd4
Publikováno v:
Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-9 (2020)
Abstract Bone homeostasis is dynamically regulated by a balance between bone resorption by osteoclasts and bone formation by osteoblasts. Visualizing and evaluating the dynamics of bone cells in vivo remain difficult using conventional technologies,
Externí odkaz:
https://doaj.org/article/516a5e184fac47c4aa0639208f9a8796
Autor:
Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-il Chung, Alexander C. Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa, Masaru Ishii
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of o
Externí odkaz:
https://doaj.org/article/06c00b6672ba4168b243c12ea9e27007
Autor:
Iyoko Katoh, Anna Mírová, Shun-ichi Kurata, Yasushi Murakami, Kenji Horikawa, Natsuko Nakakuki, Takunobu Sakai, Kunihiko Hashimoto, Ayako Maruyama, Takaaki Yonaga, Nahoko Fukunishi, Kohji Moriishi, Hirohisa Hirai
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 11, Pp 1081-1092 (2011)
The human and Old World primate genomes possess conserved endogenous retrovirus sequences that have been implicated in evolution, reproduction, and carcinogenesis. Human endogenous retrovirus (HERV)-K with 5′LTR-gag-pro-pol-env-rec/np9-3′LTR sequ
Externí odkaz:
https://doaj.org/article/8733e0c548d54d8487b8a6f5a4d87902
Autor:
Ahmed Ragaa Nour Ibrahim, PhD, Seiji Kawamoto, PhD, Keisuke Mizuno, BS, Yayoi Shimada, MS, Satoshi Rikimaru, PhD, Nobukazu Onishi, PhD, Kunihiko Hashimoto, PhD, Tsunehiro Aki, PhD, Takaharu Hayashi, MD, Kazuhisa Ono, PhD
Publikováno v:
World Allergy Organization Journal, Vol 3, Iss 11, Pp 262-265 (2010)
Protease activities in allergen sources are thought to be involved in triggering allergic inflammation through the disruption of epithelial barrier or the induction of proinflammatory cytokines. Protease allergens may also work as type 2 helper T cel
Externí odkaz:
https://doaj.org/article/95df1833998548a2b1291dd3a9b680ea
Autor:
Yukari Maeda, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Hisaya Kato, Yoshiro Maezawa, Junji Kawashima, Kayo Yoshinaga, Mai Ishikawa, Akiko Sekiguchi, Sei-Ichiro Motegi, Hironori Nakagami, Yoshihiko Yamada, Shinji Tsukamoto, Akira Taniguchi, Ken Sugimoto, Yoichi Takami, Yukiko Shoda, Kunihiko Hashimoto, Toru Yoshimura, Asako Kogure, Daisuke Suzuki, Naoki Okubo, Takashi Yoshida, Kazuhisa Watanabe, Masafumi Kuzuya, Minoru Takemoto, Junko Oshima, Koutaro Yokote
Publikováno v:
Aging. 15:3273-3294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f5e6416a0c121fdc3e9a12bdb261413
https://doi.org/10.18632/aging.204681
https://doi.org/10.18632/aging.204681
Autor:
Atsushi Yanagisawa, Yuhei Kinehara, Masaki Tanaka, Ryusuke Ninomiya, Miho Nishioka, Susumu Ochiai, Ryu Jokoji, Shoichi Ihara, Kunihiko Hashimoto, Isao Tachibana
Publikováno v:
Internal Medicine; 2023, Vol. 62 Issue 24, p3679-3683, 5p