Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kuniharu Matsuno"'
Autor:
Wenhao Cui, Kuniharu Matsuno, Kazumi Iwata, Masakazu Ibi, Masato Katsuyama, Tomoko Kakehi, Mika Sasaki, Kanako Ikami, Kai Zhu, Chihiro Yabe-Nishimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 111, Iss 3, Pp 260-268 (2009)
Beneficial effects of statins on cardiovascular diseases have been attributed to decreased generation of reactive oxygen species (ROS). We tested the hypothesis that atorvastatin protects against the development of hypertension by reducing levels of
Externí odkaz:
https://doaj.org/article/2bcfd0a9b9924c2480b86ce5a0fa2cdd
Autor:
Kazumi Iwata, Toru Nishinaka, Kuniharu Matsuno, Tomoko Kakehi, Masato Katsuyama, Masakazu Ibi, Chihiro Yabe-Nishimura
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 4, Pp 408-416 (2007)
The importance of aldose reductase (AR) has been implicated in the pathogenesis of diabetic complications, although the alterations in the expression and activity of AR during hyperglycemia in the heart have not been well characterized. We investigat
Externí odkaz:
https://doaj.org/article/bb78a335472b419092cff6fa4326ffb7
Publikováno v:
Journal of Pharmacological Sciences, Vol 102, Iss 1, Pp 37-46 (2006)
Aldose reductase (AR) has been implicated in the pathogenesis of diabetic complications, although the clinical efficacy of AR inhibitors has not been clearly proven. To clarify the pathophysiological role of AR in the heart, we investigated effects o
Externí odkaz:
https://doaj.org/article/f258459743814aee94a5e05c2eb8a7c9
Autor:
Masakazu Ibi, Xueqing Zhang, Kazumi Iwata, Natalie J. Török, Jia Zhang, Yoshinori Marunaka, Chihiro Yabe-Nishimura, Kuniharu Matsuno, Kanji Yamaguchi, Akiyuki Taruno, Yoshito Itoh, Wenhao Cui, Misaki Matsumoto, Joy X. Jiang, Junjie Liu, Masato Katsuyama
The increased production of reactive oxygen species (ROS) has been postulated to play a key role in the progression of nonalcoholic fatty liver disease (NAFLD). However, the source of ROS and mechanisms underlying the development of NAFLD have yet to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2c1962764ca072dcd16280bd943b0b
https://europepmc.org/articles/PMC5969997/
https://europepmc.org/articles/PMC5969997/
Autor:
Xiaopeng Wen, Kazumi Iwata, Chihiro Yabe-Nishimura, Makoto Ohigashi, Kai Zhu, Wenhao Cui, Misaki Matsumoto, Kuniharu Matsuno, Jia Zhang, Keiko Ikuta, Hitomi Fukui, Masato Katsuyama, Masakazu Ibi, Ayumi Murata
Publikováno v:
Free radical biologymedicine. 120
Cardiac fibrosis is a common feature in failing heart and therapeutic strategy to halt the progression of fibrosis is highly needed. We here report on NOX1, a non-phagocytic isoform of superoxide-producing NADPH oxidase, which promotes cardiac fibros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712b2aec02b0a063e518d3ada35f533e
https://pubmed.ncbi.nlm.nih.gov/29609020
https://pubmed.ncbi.nlm.nih.gov/29609020
Autor:
Masakazu Ibi, Chihiro Yabe-Nishimura, Kuniharu Matsuno, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama
Publikováno v:
Toxicology. 299:55-59
Clioquinol, a Cu²⁺/Zn²⁺/Fe²⁺ chelator/ionophor, was used extensively in the mid 1900s as an amebicide for treating indigestion and diarrhea. It was eventually withdrawn from the market because of a link to subacute myelo-optic neuropathy (SM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c0a3c1659fe4573e0cffe6306bf6db
https://doi.org/10.1016/j.tox.2012.05.013
https://doi.org/10.1016/j.tox.2012.05.013
Autor:
Kazumi Iwata, Shinichi Kato, Chihiro Yabe-Nishimura, Kikuko Amagase, Yumeno Kitahara, Daichi Utsumi, Masashi Yasuda, Kuniharu Matsuno, Maho Iimori, Koji Takeuchi, Naoki Yamanaka
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 302:G1133-G1142
Although NADPH oxidase 1 (NOX1) has been shown to be highly expressed in the gastrointestinal tract, the physiological and pathophysiological roles of this enzyme are not yet fully understood. In the present study, we investigated the role of NOX1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59626f8e5ce50efe6540cf5d2c2a81c0
https://doi.org/10.1152/ajpgi.00535.2011
https://doi.org/10.1152/ajpgi.00535.2011
Autor:
Chihiro Yabe-Nishimura, Kazumi Iwata, Masakazu Ibi, Masato Katsuyama, Misaki Matsumoto, Hideyo Hirai, Kuniharu Matsuno
Publikováno v:
FEBS Journal. 278:964-972
NOX is the catalytic subunit of NADPH oxidase, the superoxide-generating enzyme. Among several isoforms of NOX, NOX4 is abundantly expressed in various tissues. To clarify the mechanisms of constitutive and ubiquitous expression of NOX4, the promoter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97fb2c3b7e3b34c1c21c20980c4d227b
https://doi.org/10.1111/j.1742-4658.2011.08018.x
https://doi.org/10.1111/j.1742-4658.2011.08018.x
Publikováno v:
Journal of Clinical Biochemistry and Nutrition
NADPH oxidase is a superoxide (O(2) (•-))-generating enzyme first identified in phagocytes, essential for their bactericidal activities. Later, in non-phagocytes, production of O(2) (•-) was also demonstrated in an NADPH-dependent manner. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a93c4d0dc910ab153f7bd0b05a3b504
https://doi.org/10.3164/jcbn.11-06sr
https://doi.org/10.3164/jcbn.11-06sr
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704853430515273210f13fd394516e65
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-3-12
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-3-12