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pro vyhledávání: '"Kuniaki Morisaki"'
Supplementary Figures S1-S6 from Histone Modifications at the ABCG2 Promoter following Treatment with Histone Deacetylase Inhibitor Mirror Those in Multidrug-Resistant Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa0cb9ac36ecc8b6e3ee67dbbb6f206
https://doi.org/10.1158/1541-7786.22521304
https://doi.org/10.1158/1541-7786.22521304
Autor:
Andrea Abati, Kuniaki Morisaki, Patricia Fetsch, Susan E. Bates, Yasumasa Honjo, Khush Mittal, Thomas Litman
Publikováno v:
Cancer Letters. 235:84-92
Reduced drug accumulation due to overexpression of individual members of the ATP binding cassette (ABC) superfamily of membrane transporters has been investigated as a cause of multidrug resistance and treatment failure in oncology. This study was de
Autor:
Susan E. Bates, Csilla Özvegy-Laczka, Orsolya Polgar, Gabriella Köblös, Balázs Sarkadi, Robert W. Robey, Masaki Okada, Akina Tamaki, Michael Dean, Yvona Ward, Kuniaki Morisaki, N. Barry Elkind
Publikováno v:
Biochemistry. 45:5251-5260
ABCG2 is an ATP-binding cassette half-transporter conferring resistance to chemotherapeutic agents such as mitoxantrone, irinotecan, and flavopiridol. With its one transmembrane and one ATP-binding domain, ABCG2 is thought to homodimerize for functio
Autor:
Balázs Sarkadi, Csilla Özvegy-Laczka, Kenneth Steadman, Kuniaki Morisaki, Yasumasa Honjo, Susan E. Bates, Robert W. Robey, Orsolya Polgar
Publikováno v:
Cancer Chemotherapy and Pharmacology. 56:161-172
Single nucleotide polymorphism (SNP) analyses of the ABCG2 gene have revealed three nonsynonymous SNPs resulting in the amino acid changes at V12M, Q141K and D620N. To determine whether the SNPs have an effect on drug transport, human embryonic kidne
Autor:
Suresh V. Ambudkar, Robert W. Robey, Michael Dean, Kuniaki Morisaki, Zuben E. Sauna, Christopher J. Michejda, Susan E. Bates, Nadya I. Tarasova, Orsolya Polgar
Publikováno v:
Biochemistry. 43:9448-9456
ABCG2 (BCRP/MXR/ABCP) is a half-transporter associated with multidrug resistance that presumably homodimerizes for function. It has a conserved GXXXG motif in its first transmembrane segment, a motif that has been linked with dimerization in other pr
Autor:
Prakash Mistry, Susan E. Bates, Margaret Blayney, Orsolya Polgar, Robert W. Robey, Kuniaki Morisaki, Kenneth Steadman
Publikováno v:
Cancer Research. 64:1242-1246
Pheophorbide a (PhA), a chlorophyll catabolite, was shown to be an ABCG2 substrate based on Abcg2−/− knockout mouse studies (J. W. Jonker et al., Proc. Natl. Acad. Sci. USA, 99: 15649–15654, 2002). We developed a functional assay for ABCG2 usin
Autor:
T A Nadjem, Yasumasa Honjo, Marianne S. Poruchynsky, M Risbood, S Runge, Kuniaki Morisaki, Robert W. Robey, Susan E. Bates
Publikováno v:
British Journal of Cancer
Recent studies have shown that mutations at amino-acid 482 in the ABCG2 gene affect the substrate specificity of the protein. To delineate the effects of these mutations clearly, human embryonic kidney cells (HEK-293) were stably transfected with wil
Publikováno v:
Neurologia medico-chirurgica. 43:573-581
The present study evaluated whether technetium-99m sestamibi (99mTc-MIBI) single photon emission computed tomography (SPECT) characteristics of intracranial meningioma are correlated with the histological malignancy, proliferative potential, and P-gl
Autor:
Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Yasumasa Honjo, Michael Dean, Susan E. Bates, Jeffrey Hung
Publikováno v:
Cancer Biology & Therapy. 1:696-702
Variations in the amino acid sequence of ABC transporters have been shown to impact substrate specificity. We identified two acquired mutations in ABCG2, the ABC half-transporter overexpressed in mitoxantrone-resistant cell lines. These mutations con
Autor:
Kenya Kawakita, Kuniaki Morisaki, Seigo Nagao, Keisuke Miyake, Katsuzo Kunishio, Yoshihito Matsumoto
Publikováno v:
Japanese Journal of Neurosurgery. 10:469-474