Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Kuniaki, Mukai"'
Publikováno v:
Endocrine Journal, Vol 70, Iss 12, Pp 1113-1122 (2023)
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the
Externí odkaz:
https://doaj.org/article/d64fbc05fb574bae955f0ef52c358448
Autor:
Nae Takizawa, Susumu Tanaka, Koshiro Nishimoto, Yuki Sugiura, Makoto Suematsu, Chisato Ohe, Haruyuki Ohsugi, Yosuke Mizuno, Kuniaki Mukai, Tsugio Seki, Kenji Oki, Celso E. Gomez-Sanchez, Tadashi Matsuda
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 1, Pp 128-138 (2021)
Primary aldosteronism is most often caused by aldosterone-producing adenoma (APA) and bi-lateral adrenal hyperplasia. Most APAs are caused by somatic mutations of various ion channels and pumps, the most common being the inward-rectifying potassium c
Externí odkaz:
https://doaj.org/article/5a6de17491a143b8b902dfaecde28178
Autor:
Kuniaki Mukai, Hiroshi Sugimoto, Katsumasa Kamiya, Reiko Suzuki, Tomomi Matsuura, Takako Hishiki, Hideo Shimada, Yoshitsugu Shiro, Makoto Suematsu, Norio Kagawa
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 192-205 (2021)
Human cytochromes P45011β (CYP11B1) and P450aldo (CYP11B2) are monooxygenases that synthesize cortisol through steroid 11β-hydroxylation and aldosterone through a three-step process comprising 11β-hydroxylation and two 18-hydroxylations, respectiv
Externí odkaz:
https://doaj.org/article/e62e9dc1a93e4d66ae0ade14f6d04781
Autor:
Nae Takizawa, Susumu Tanaka, Koshiro Nishimoto, Yuki Sugiura, Makoto Suematsu, Chisato Ohe, Haruyuki Ohsugi, Yosuke Mizuno, Kuniaki Mukai, Tsugio Seki, Kenji Oki, Celso E. Gomez-Sanchez, Tadashi Matsuda
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 10, Pp 128-138 (2022)
Primary aldosteronism is most often caused by aldosterone-producing adenoma (APA) and bi-lateral adrenal hyperplasia. Most APAs are caused by somatic mutations of various ion channels and pumps, the most common being the inward-rectifying potassium c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4664b85cac528510d25f4967f4234a
https://www.mdpi.com/1467-3045/44/1/10
https://www.mdpi.com/1467-3045/44/1/10
Autor:
Norifusa Iwahashi, Hironobu Umakoshi, Tsugio Seki, Celso E Gomez-Sanchez, Kuniaki Mukai, Makoto Suematsu, Yuta Umezawa, Mototsugu Oya, Takeo Kosaka, Masahide Seki, Yutaka Suzuki, Yutaka Horiuchi, Yoshihiro Ogawa, Koshiro Nishimoto
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:2439-2448
Context The adrenal cortex consists of zona glomerulosa (ZG), fasciculata (ZF), and reticularis. Aldosterone-producing cell clusters (APCCs) that strongly express aldosterone synthase (CYP11B2) are frequently found in adult adrenals and harbor somati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f88944d86b76829ba01e7cc8242372
https://doi.org/10.1210/clinem/dgac394
https://doi.org/10.1210/clinem/dgac394
Autor:
Yoji Andrew Minamishima, Makoto Suematsu, Hideyuki Saya, Ryo Fukuda, Takehiro Yamamoto, Noriyo Hayakawa, Yoshiko Nagahata, Tomomi Matsuura, Yuki Sugiura, Mitsuyo Ohmura, Akiko Kubo, Takako Hishiki, Kuniaki Mukai, Yan Bao
PDF - 1735K, Table S1: Percentages of Fucci-HTC116 in S + G2 and G1 phases in mouse liver metastatic foci. Table S2: Numbers of MALDO-IMS measurement points in mouse liver metastatic foci. Figure S1: Frequency distribution of relative intensities of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb53af9e9bf6b796683c04fde1e7d29
https://doi.org/10.1158/1541-7786.22509174.v1
https://doi.org/10.1158/1541-7786.22509174.v1
Autor:
Yoji Andrew Minamishima, Makoto Suematsu, Hideyuki Saya, Ryo Fukuda, Takehiro Yamamoto, Noriyo Hayakawa, Yoshiko Nagahata, Tomomi Matsuura, Yuki Sugiura, Mitsuyo Ohmura, Akiko Kubo, Takako Hishiki, Kuniaki Mukai, Yan Bao
Activation of aerobic glycolysis in cancer cells is well known as the Warburg effect, although its relation to cell- cycle progression remains unknown. In this study, human colon cancer cells were labeled with a cell-cycle phase-dependent fluorescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73131d18bef596a417f3e538206412fe
https://doi.org/10.1158/1541-7786.c.6539217.v1
https://doi.org/10.1158/1541-7786.c.6539217.v1
Autor:
Elle van de Wiel, Amir-Hossein Chaman Baz, Benno Küsters, Kuniaki Mukai, Lidia van Bonzel, Merijn van Erp, Jaap Deinum, Johan Langenhuijsen
Publikováno v:
Hypertension, 79, 2565-2572
Hypertension, 79, 11, pp. 2565-2572
Hypertension, 79, 11, pp. 2565-2572
Background: Aldosterone synthase (CYP11B2) antibodies for immunohistochemistry, enables to visualize aldosterone-producing zona glomerulosa (ZG), aldosterone-producing micronodules, and aldosterone-producing adenomas. The architecture of the ZG diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acf28d4a8af09acb8ae8996cf47e064
https://doi.org/10.1161/HYPERTENSIONAHA.122.19052
https://doi.org/10.1161/HYPERTENSIONAHA.122.19052
Autor:
Hiroshi Sugimoto, Reiko Suzuki, Takako Hishiki, Makoto Suematsu, Norio Kagawa, Katsumasa Kamiya, Tomomi Matsuura, Hideo Shimada, Kuniaki Mukai, Yoshitsugu Shiro
Publikováno v:
Current Research in Structural Biology
Current Research in Structural Biology, Vol 3, Iss, Pp 192-205 (2021)
Current Research in Structural Biology, Vol 3, Iss, Pp 192-205 (2021)
Human cytochromes P45011β (CYP11B1) and P450aldo (CYP11B2) are monooxygenases that synthesize cortisol through steroid 11β-hydroxylation and aldosterone through a three-step process comprising 11β-hydroxylation and two 18-hydroxylations, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a699fe4786313f3b236f58573b88d18
https://doi.org/10.1016/j.crstbi.2021.08.001
https://doi.org/10.1016/j.crstbi.2021.08.001
Autor:
Koshiro Nishimoto, Tsugio Seki, Yuichiro Hayashi, Shuji Mikami, Ghaith Al-Eyd, Ken Nakagawa, Shinya Morita, Takeo Kosaka, Mototsugu Oya, Fumiko Mitani, Makoto Suematsu, Yasuaki Kabe, Kuniaki Mukai
Publikováno v:
International Journal of Endocrinology, Vol 2016 (2016)
Background. The immunohistochemical detection of aldosterone synthase (CYP11B2) and steroid 11β-hydroxylase (CYP11B1) has enabled the identification of aldosterone-producing cell clusters (APCCs) in the subcapsular portion of the human adult adrenal
Externí odkaz:
https://doaj.org/article/80206167bc0240bc84b7f3ff3780fdd2