Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kung-Pern Wang"'
Autor:
Kung-Pern Wang, 王坤鵬
92
The first chapter of this thesis describes the generation of a focused library of 2,4,5-triarylimidazoles and the screening of biological activities of the members thereof. Starting with substituted methyl benzoates, treatment with 4-lithium
The first chapter of this thesis describes the generation of a focused library of 2,4,5-triarylimidazoles and the screening of biological activities of the members thereof. Starting with substituted methyl benzoates, treatment with 4-lithium
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/v4v3wt
Publikováno v:
Angewandte Chemie (International Ed. in English)
Here we describe a general method for the synthesis of 2,5‐diaminoimidazoles, which involves a thermal reaction between α‐aminoketones and substituted guanylhydrazines without the need for additives. As one of the few known ways to access the 2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444e928a2edf1cf57f6fd2b4a804c73c
https://doi.org/10.1002/ange.201911156
https://doi.org/10.1002/ange.201911156
Publikováno v:
Chem. Sci.. 5:2362-2367
Formal hydrogenation of arynes was realized by using trialkylsilyl groups tethered to the arynes as the hydride source. In stark contrast to the effective 1°, 2°, and 3° C–H bond insertion of alkyl groups tethered to arynes, the 2° and 3° C–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54b96104c77ccf3c990a1da372ed83e
https://doi.org/10.1039/c3sc53478b
https://doi.org/10.1039/c3sc53478b
Autor:
Michelle Ulrich, Steven Jin, Jessica K. Simmons, Fu Li, Robert P. Lyon, Abbie Wong, Weiping Zeng, Julia H. Cochran, Kung Pern Wang, Andrew B. Waight, Paul G. Pittman, David W. Meyer, Chris Neumann, Martha Anderson, Margo Zaval, Peter D. Senter, Kathleen C. Olivas, Luke V. Loftus
Publikováno v:
Cancer Research. 79:983-983
Nicotinamide phosphoribosyltransferase (NAMPT) regulates the biosynthesis of NAD from nicotinamide via a salvage biosynthetic pathway. Inhibition of NAMPT depletes cellular NAD levels leading to disruption of energy metabolism and cell death. Non-tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4619283e04f0c23f9c6b7da4df33e659
https://doi.org/10.1158/1538-7445.am2019-983
https://doi.org/10.1158/1538-7445.am2019-983
Publikováno v:
Organic Letters. 16:6-9
The regioselectivity in nucleophile trapping is investigated with arynes generated directly from bis-1,3-diynes. The regioselectivity is profoundly influenced by not only the nature of nucleophiles but also the substituents on the arynes, which is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7350a5b1f5ff3ea98916706d0d3814be
https://doi.org/10.1021/ol403237z
https://doi.org/10.1021/ol403237z
Publikováno v:
Tetrahedron. 69:9105-9110
Enyne cross metathesis of terminal 1,3-diynes with various alkenes afforded two products of distinctive connectivity, as the result of a uniform mode of initiation but different modes of termination events with or without metallotropic [1,3]-shift. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeec12c31e8bd94b27aa346d01ad160c
https://doi.org/10.1016/j.tet.2013.08.024
https://doi.org/10.1016/j.tet.2013.08.024
Publikováno v:
Organicbiomolecular chemistry. 14(21)
A new functionalization method of arynes promoted by a novel catalytic role of the Grubbs-type ruthenium alkylidene complex is described. Through a sequence of aryne formation followed by their halo-functionalization, various bis-1,3-diynes were dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8c3f6cd4ffd3df55719fa47f88b99f
https://pubmed.ncbi.nlm.nih.gov/27145857
https://pubmed.ncbi.nlm.nih.gov/27145857
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 21(48)
The mechanisms of regiodivergent cyclizations of o-alkynylbenzaldehyde acetals and thioacetals catalyzed by Pd and Pt halides are studied. DFT calculations found that both reactions are initiated by electrophilic activation of the acetylenic moiety i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad3342b8745f3cceb0858d88a72890a
https://pubmed.ncbi.nlm.nih.gov/26377745
https://pubmed.ncbi.nlm.nih.gov/26377745
Autor:
Ali Khalafi-Nezhad, Kak-Shan Shia, Kung-Pern Wang, Ali Akbar Saboury, Ali Akbar Moosavi-Movahedi, Shahram Hakimelahi, Gholam Hossein Hakimelahi, Jyh-Hsiung Liao, Cuihua Xue, Valeriy Osyetrov, Fen-Tair Luo, Mohammad N Soltani-Rad
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:3489-3498
By use of pro-dual-drug concept the synthesis of 6-beta-[(R)-2-(clavaminio-9-N-yl)-2-(4-hydroxyphenylacetamido)]penicillanic acid (10), 6-beta-[(R)-2-(amino)-2-(4-(clavulano-9-O-yl)phenylacetamido)]penicillanic acid (13), (Z)-4-[2-(amoxycillin-4-O-yl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c98b5ca6e1d319ccbef6729f8202f2
https://doi.org/10.1016/s0968-0896(02)00256-0
https://doi.org/10.1016/s0968-0896(02)00256-0
Publikováno v:
ChemInform. 45
In contrast 2° and 3° C-H bonds on the silyl groups are exclusively subject to a hydride transfer to generate formal hydrogenation products [e.g. (II)] whereas, the corresponding 1° C-H bonds participate in only a direct C-H insertion process [e.g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a0722bac3085bafb2e4fd64c3b839e
https://doi.org/10.1002/chin.201443185
https://doi.org/10.1002/chin.201443185