Gradient Estimation for Binary Latent Variables via Gradient Variance Clipping

Autor: Kunes, Russell Z., Yin, Mingzhang, Land, Max, Haviv, Doron, Pe'er, Dana, Tavaré, Simon

Gradient estimation is often necessary for fitting generative models with discrete latent variables, in contexts such as reinforcement learning and variational autoencoder (VAE) training. The DisARM estimator (Yin et al. 2020; Dong, Mnih, and Tucker

Externí odkaz: http://arxiv.org/abs/2208.06124

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Author Correction: Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy.

Autor: Walle T; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany. t.walle@dkfz.de.; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany. t.walle@dkfz.de.; German Cancer Consortium (DKTK), Heidelberg, Germany. t.walle@dkfz.de., Bajaj S; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kraske JA; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Rösner T; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Cussigh CS; Department of Dermatology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kälber KA; Department of Dermatology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Müller LJ; Department of Hematology, University Hospital Heidelberg, Heidelberg, Germany., Strobel SB; Department of Dermatology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Burghaus J; Department of Dermatology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kallenberger SM; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Stein-Thöringer CK; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Division Microbiome and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jenzer M; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Schubert A; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; BioQuant & Department of Cell and Molecular Biology, Heidelberg University, Heidelberg, Germany.; Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kahle S; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Williams A; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Hoyler B; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zielske L; NCT Liquid Biobank, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Skatula R; NCT Liquid Biobank, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Sawall S; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany., Leber MF; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kunes RZ; Department of Statistics, Columbia University, New York, NY, USA., Krisam J; Institute of Medical Biometry, Heidelberg University, Heidelberg, Germany., Fremd C; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Division of Gynecological Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Schneeweiss A; Division of Gynecological Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Krauss J; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Apostolidis L; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Berger AK; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Haag GM; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany., Zschäbitz S; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Halama N; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Department of Translational Immunotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Helmholtz Institute for Translational Oncology (HITRON), Mainz, Germany., Springfeld C; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Kirsten R; NCT Liquid Biobank, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Hassel JC; Department of Dermatology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Jäger D; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumor-Immunity, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ungerechts G; Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.; CanVirex, Heidelberg, Germany.; Ottawa Hospital Research Institute, Cancer Therapeutics Program, Ottawa, Ontario, Canada.

Publikováno v: Nature cancer [Nat Cancer] 2022 Sep; Vol. 3 (9), pp. 1137.