Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Kunderfranco, P"'
Autor:
Federica Portale, Roberta Carriero, Marta Iovino, Paolo Kunderfranco, Marta Pandini, Giulia Marelli, Nicolò Morina, Massimo Lazzeri, Paolo Casale, Piergiuseppe Colombo, Gabriele De Simone, Chiara Camisaschi, Enrico Lugli, Gianluca Basso, Javier Cibella, Sergio Marchini, Matteo Bordi, Greta Meregalli, Anna Garbin, Monica Dambra, Elena Magrini, Wiebke Rackwitz, Francesco Cecconi, Alessandro Corbelli, Fabio Fiordaliso, Jiri Eitler, Torsten Tonn, Diletta Di Mitri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract NK cells are endowed with tumor killing ability, nevertheless most cancers impair NK cell functionality, and cell-based therapies have limited efficacy in solid tumors. How cancers render NK cell dysfunctional is unclear, and overcoming resi
Externí odkaz:
https://doaj.org/article/d96fe7cd9b7847dea66f22912cd5bddc
Autor:
Alessandra Pulvirenti, Marialuisa Barbagallo, Anna Rita Putignano, Antonio Pea, Rebecca Polidori, Rosie Upstill-Goddard, Nina Cortese, Paolo Kunderfranco, Laura Brunelli, Giulia De Simone, Roberta Pastorelli, Paola Spaggiari, Gennaro Nappo, Nigel B. Jamieson, Alessandro Zerbi, David K. Chang, Giovanni Capretti, Federica Marchesi
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionMetabolic reprogramming is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC). A pancreatic juice (PJ) metabolic signature has been reported to be prognostic of oncological outcome for PDAC. Integration of PJ profiling with tra
Externí odkaz:
https://doaj.org/article/a7368bd159a94ff69e5350a5c10d750f
Akademický článek
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Akademický článek
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Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297872 (2024)
Macrophages, key players in the innate immune system, showcase remarkable adaptability. Derived from monocytes, these phagocytic cells excel in engulfing and digesting pathogens and foreign substances as well as contributing to antigen presentation,
Externí odkaz:
https://doaj.org/article/e91215a12b15408eb3c3eee1c79a511a
Autor:
Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip S. Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, Marcel H. Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How and whether histone modifications regulate distinct gene networks remains insufficiently understood. Here Cattaneo et al show that DOT1L catalyzed H3K79me2 regulates fetal chamber-specific gene expression and neonatal cardiomyocyte cell cycle wit
Externí odkaz:
https://doaj.org/article/af78efbb43a14df4a0071f5cb6653928
Akademický článek
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Autor:
Irene Salamon, Elena Biagini, Paolo Kunderfranco, Roberta Roncarati, Manuela Ferracin, Nevio Taglieri, Elena Nardi, Noemi Laprovitera, Luciana Tomasi, Marisa Santostefano, Raffaello Ditaranto, Giovanni Vitale, Elena Cavarretta, Antonio Pisani, Eleonora Riccio, Valeria Aiello, Irene Capelli, Gaetano La Manna, Nazzareno Galiè, Letizia Spinelli, Gianluigi Condorelli
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-7 (2021)
Abstract Enzyme replacement therapy (ERT) is a mainstay of treatment for Anderson–Fabry disease (AFD), a pathology with negative effects on the heart and kidneys. However, no reliable biomarkers are available to monitor its efficacy. Therefore, we
Externí odkaz:
https://doaj.org/article/536cee0577a8412385a0e329a057c0c8
Autor:
Claudia Carenza, Sara Franzese, Alessandra Castagna, Sara Terzoli, Matteo Simonelli, Pasquale Persico, Lorenzo Bello, Marco Conti Nibali, Federico Pessina, Paolo Kunderfranco, Clelia Peano, Simone Balin, Joanna Mikulak, Francesca Calcaterra, Raffaella Bonecchi, Benedetta Savino, Massimo Locati, Silvia Della Bella, Domenico Mavilio
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionAdult-type diffuse gliomas are malignant primary brain tumors characterized by very poor prognosis. Dendritic cells (DCs) are key in priming antitumor effector functions in cancer, but their role in gliomas remains poorly understood.Metho
Externí odkaz:
https://doaj.org/article/c5fce43a13f743ad9cbbc87709c2dfa9
Autor:
Marita Zoma, Laura Curti, Dheeraj Shinde, Domenico Albino, Abhishek Mitra, Jacopo Sgrignani, Sarah N. Mapelli, Giada Sandrini, Gianluca Civenni, Jessica Merulla, Giovanna Chiorino, Paolo Kunderfranco, Alessia Cacciatore, Aleksandra Kokanovic, Andrea Rinaldi, Andrea Cavalli, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Although the TMPRSS2-ERG gene fusion is the most common alteration in human prostate cancer, its involvement in disease progression remains unclear. Here, the authors demonstrate that ERG is methylated by Enhancer of zest homolog 2 leading to enhance
Externí odkaz:
https://doaj.org/article/e634d5688e6b4dc7aff08bbd1aa3f1c9