Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kunchur Guruprasad"'
Autor:
Kunchur Guruprasad
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 41-50 (2022)
The comparison of 303,250 human SARS-CoV-2 spike protein sequences with the reference protein sequence Wuhan-Hu-1, showed ∼96.5% of the spike protein sequence has undergone the mutations till date, since outbreak of the COVID-19 pandemic disease th
Externí odkaz:
https://doaj.org/article/57b7505308674ae58f0ac314876dc5f4
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139568 (2015)
The analyses of 3967 representative proteins selected from the Protein Data Bank revealed the presence of 2803 pentapeptide and large palindrome sequences with known secondary structure conformation. These represent 2014 unique palindrome sequences.
Externí odkaz:
https://doaj.org/article/21825f37ca364fdbab364478fc458de6
Autor:
Diana Fatykhova, Anne Rabes, Christoph Machnik, Kunchur Guruprasad, Florence Pache, Johanna Berg, Mario Toennies, Torsten T Bauer, Paul Schneider, Maria Schimek, Stephan Eggeling, Timothy J Mitchell, Andrea M Mitchell, Rolf Hilker, Torsten Hain, Norbert Suttorp, Stefan Hippenstiel, Andreas C Hocke, Bastian Opitz
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0137108 (2015)
Streptococcus pneumoniae is a major cause of pneumonia, sepsis and meningitis. The pore-forming toxin pneumolysin is a key virulence factor of S. pneumoniae, which can be sensed by the NLRP3 inflammasome. Among the over 90 serotypes, serotype 1 pneum
Externí odkaz:
https://doaj.org/article/4376408cd81345ebbd0afd0a1437f7cd
Autor:
Settu Sridhar, Kunchur Guruprasad
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107647 (2014)
We have carried out a systematic computational analysis on a representative dataset of proteins of known three-dimensional structure, in order to evaluate whether it would possible to 'swap' certain short peptide sequences in naturally occurring prot
Externí odkaz:
https://doaj.org/article/9b906587086746d190cf7702a243b4b8
Autor:
Kunchur Guruprasad
The amino acid mutations among 28,345 poly-protein sequences corresponding to human SARS-CoV-2 orf1AB gene representing the six geographical locations; Africa, Asia, Europe, North America, Oceania and South America were identified by comparing with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acaee094558ef7c060982b66e797f55
https://doi.org/10.26434/chemrxiv-2021-lf2zd-v2
https://doi.org/10.26434/chemrxiv-2021-lf2zd-v2
Autor:
Kunchur Guruprasad
The comparison of 10,929 human SARS-CoV-2 RdRp protein sequences representing six geographical locations with the reference protein sequence in human SARS-CoV-2 genome isolate from Wuhan, China, identified 222 distinct mutation sites in the RdRp prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2466a2ebb34d38983ad1c3d72108d4
https://doi.org/10.26434/chemrxiv.13515116.v1
https://doi.org/10.26434/chemrxiv.13515116.v1
Autor:
Kunchur Guruprasad
The amino acid residue mutations observed in SARS CoV-2 RNA dependent RNA polymerase, helicase, endoRNAse and spike proteins from Indian isolates, relative to the reference SARS CoV-2 proteins from the Wuhan Hu-1 isolate, were mapped onto the protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23a0fdf30dcb439fe457179d6ea3a7ea
https://doi.org/10.26434/chemrxiv.12683771.v1
https://doi.org/10.26434/chemrxiv.12683771.v1
Autor:
Kunchur Guruprasad
We report here all amino acid residue mutations present among the proteins in 22 Indian isolates of the human SARS CoV-2 complete genomes analyzed from the public repository of the NCBI databank. The isolates analysed are from 4 States of India and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b71591667f96b208eb07f6171ff17cb
https://doi.org/10.26434/chemrxiv.12300860
https://doi.org/10.26434/chemrxiv.12300860
Publikováno v:
BMC Structural Biology
BMC Structural Biology, Vol 18, Iss 1, Pp 1-13 (2018)
BMC Structural Biology, Vol 18, Iss 1, Pp 1-13 (2018)
Background Earlier based on bioinformatics analyses, we had predicted the Mycobacterium tuberculosis (M.tb) proteins; Rv1555 and Rv1554, among the potential new tuberculosis drug targets. According to the ‘TB-drugome’ the Rv1555 protein is ‘dru
Three-dimensional coordinates of the M.tb dimer protein complexed with vardenafil in the PDB format. (DOC 224Â kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3240f27b2e94e8f903c9ab2180dd8366