Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kunal, Baxi"'
Autor:
Jiangfei Chen, Kunal Baxi, Amanda E Lipsitt, Nicole Rae Hensch, Long Wang, Prethish Sreenivas, Paulomi Modi, Xiang Ru Zhao, Antoine Baudin, Daniel G Robledo, Abhik Bandyopadhyay, Aaron Sugalski, Anil K Challa, Dias Kurmashev, Andrea R Gilbert, Gail E Tomlinson, Peter Houghton, Yidong Chen, Madeline N Hayes, Eleanor Y Chen, David S Libich, Myron S Ignatius
Publikováno v:
eLife, Vol 12 (2023)
In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function TP53 mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding p5
Externí odkaz:
https://doaj.org/article/869c09202a0d4108bb57d631b09af023
Autor:
Panneerdoss Subbarayalu, Pooja Yadav, Santosh Timilsina, Daisy Medina, Kunal Baxi, Robert Hromas, Ratna K. Vadlamudi, Yidong Chen, Patrick Sung, Manjeet K. Rao
Publikováno v:
Cells, Vol 12, Iss 9, p 1283 (2023)
Eukaryotic cells maintain cellular fitness by employing well-coordinated and evolutionarily conserved processes that negotiate stress induced by internal or external environments. These processes include the unfolded protein response, autophagy, endo
Externí odkaz:
https://doaj.org/article/6c4152b2a7b1458eac61c892efb6575e
Autor:
Silvia Pomella, Prethish Sreenivas, Berkley E. Gryder, Long Wang, David Milewski, Matteo Cassandri, Kunal Baxi, Nicole R. Hensch, Elena Carcarino, Young Song, Hsien-Chao Chou, Marielle E. Yohe, Benjamin Z. Stanton, Bruno Amadio, Ignazio Caruana, Cristiano De Stefanis, Rita De Vito, Franco Locatelli, Yidong Chen, Eleanor Y. Chen, Peter Houghton, Javed Khan, Rossella Rota, Myron S. Ignatius
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Rhabdomyosarcomas are tumours blocked in myogenic differentiation, which despite the expression of master muscle regulatory factors, including MYOD, are unable to differentiate. Here, the authors show that SNAI2 is upregulated by MYOD through super e
Externí odkaz:
https://doaj.org/article/13792164b2674112a670f2c8b5793e7e
Autor:
Richard Bowman, Nathan Balukoff, Amy Clemons, Emily Koury, Talitha Ford, Kunal Baxi, Carlos Egydio de Carvalho, Sarit Smolikove
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 1, Pp 387-400 (2020)
Externí odkaz:
https://doaj.org/article/0dc048df5a1a4e59a6da6f1eb94ada70
Autor:
Ata Ghavidel, Kunal Baxi, Martin Prusinkiewicz, Cynthia Swan, Zach R. Belak, Christopher H. Eskiw, Carlos E. Carvalho, Troy A. Harkness
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 5, Pp 1579-1592 (2018)
The yeast, Saccharomyces cerevisiae, like other higher eukaryotes, undergo a finite number of cell divisions before exiting the cell cycle due to the effects of aging. Here, we show that yeast aging begins with the nuclear exclusion of Hcm1 in young
Externí odkaz:
https://doaj.org/article/5102f45718a241e8b263a725b4e00d9f
Autor:
Kunal Baxi, Jiangfei Chen, Amanda Lipsitt, Nicole Hensch, Long Wang, Abhik Bandopadhyay, Aaron Sugalski, Andrea Gilbert, Eleanor Chen, Peter Houghton, Gail Tomlinson, Myron Ignatius
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 19-20 (2021)
ABSTRACT IMPACT: By assessing function of mutant (patient-specific) tp53 in zebrafish embryonal rhabdomyosarcoma will inform clinicians of the severity of mutant tp53 alleles. OBJECTIVES/GOALS: This study aims to define loss- and gain-of-function TP5
Externí odkaz:
https://doaj.org/article/746745541b8e4723853ee28927b8c2b3
Autor:
Angelina V. Vaseva, Peter J. Houghton, Kris C. Wood, Myron S. Ignatius, William D. Figg, Cody J. Peer, Sara M. Zimmerman, Anna T. Rogojina, Yidong Chen, Kunal Baxi, Long Wang, Terry J. Shackleford, Craig M. Goodwin, Marielle E. Yohe, Vanessa Del Pozo, Natalia Garcia
Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector pathway in mediating RAS dependency in a panel of H/NRASQ61X mutant RMS cells and correlates in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8284cff2d8a98fdac0344310698ee
https://doi.org/10.1158/1535-7163.c.6543340
https://doi.org/10.1158/1535-7163.c.6543340
Autor:
Angelina V. Vaseva, Peter J. Houghton, Kris C. Wood, Myron S. Ignatius, William D. Figg, Cody J. Peer, Sara M. Zimmerman, Anna T. Rogojina, Yidong Chen, Kunal Baxi, Long Wang, Terry J. Shackleford, Craig M. Goodwin, Marielle E. Yohe, Vanessa Del Pozo, Natalia Garcia
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d3e61604c7ec0285e0bd4364f173cc
https://doi.org/10.1158/1535-7163.22522342
https://doi.org/10.1158/1535-7163.22522342
Autor:
Angelina V. Vaseva, Peter J. Houghton, Kris C. Wood, Myron S. Ignatius, William D. Figg, Cody J. Peer, Sara M. Zimmerman, Anna T. Rogojina, Yidong Chen, Kunal Baxi, Long Wang, Terry J. Shackleford, Craig M. Goodwin, Marielle E. Yohe, Vanessa Del Pozo, Natalia Garcia
Supplementary figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a5ff6f98e44014e486437be70565a6
https://doi.org/10.1158/1535-7163.22522345.v1
https://doi.org/10.1158/1535-7163.22522345.v1
Autor:
Myron S. Ignatius, Peter J. Houghton, Javed Khan, Rossella Rota, Eleanor Y. Chen, Siyuan Zheng, Benjamin Z. Stanton, Silvia Pomella, Berkley E. Gryder, Benjamin D. Sunkel, Angelina V. Vaseva, Kunal Baxi, Rodrigo Moreno Campos, Jiangfei Chen, Xiang R. Zhao, Prethish Sreenivas, Kathryn Bondra, Nicole R. Hensch, Long Wang
Materials and Methods used for experiments in Supplemental Figures and Supplemental References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e197ff05af2e7311b611224ccc88a71
https://doi.org/10.1158/0008-5472.22428190.v1
https://doi.org/10.1158/0008-5472.22428190.v1